BDBM29589 Faridak::LBH-589::LBH-589B::Panobinostat::US10722597, Compound Panobinostat
SMILES Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
InChI Key InChIKey=FPOHNWQLNRZRFC-ZHACJKMWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 29589
Affinity DataKi: 0.540nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Inhibition of human recombinant HDAC3 using fluorogenic HDAC substrate after 10 mins by spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of human recombinant HDAC1 using fluorogenic HDAC substrate after 15 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 5.10nMAssay Description:Inhibition of human recombinant HDAC10 using fluorogenic HDAC substrate after 45 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Inhibition of human recombinant HDAC2 using fluorogenic HDAC substrate after 15 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 54nMAssay Description:Inhibition of human recombinant HDAC6 using fluorogenic HDAC substrate after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 57nMAssay Description:Inhibition of human recombinant HDAC5 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Inhibition of human recombinant HDAC8 using fluorogenic HDAC substrate after 15 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Inhibition of human recombinant HDAC4 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 630nMAssay Description:Inhibition of human recombinant HDAC7 using fluorogenic HDAC substrate class 2a after 45 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 830nMAssay Description:Inhibition of human recombinant HDAC9 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nMAssay Description:Inhibition of human recombinant HDAC11 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by ChEMBL
Nestle Skin Health R&D
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant SIRT1 using fluorogenic HDAC substrate after 20 mins by fluorimetrc methodMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-7(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by ChEMBL
Nestle Skin Health R&D
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of SIRT7 (unknown origin)More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by ChEMBL
Nestle Skin Health R&D
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant SIRT3 using fluoro-lysine sirtuin 2 deacetylase substrate after 45 mins by fluorimetrc methodMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by ChEMBL
Nestle Skin Health R&D
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant SIRT2 using fluoro-lysine sirtuin 2 deacetylase substrate after 60 mins by fluorimetrc methodMore data for this Ligand-Target Pair