BindingDB BDBM29589 Faridak::LBH-589::LBH-589B::Panobinostat::US10722597, Compound Panobinostat

BDBM29589 Faridak::LBH-589::LBH-589B::Panobinostat::US10722597, Compound Panobinostat

SMILES Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1

InChI Key InChIKey=FPOHNWQLNRZRFC-ZHACJKMWSA-N

Data 40 KI 165 IC50 2 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 29589

Histone deacetylase 1(Homo sapiens (Human))
Midatech

US Patent

BDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)

IC50: 1.61nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Histone deacetylase 2(Homo sapiens (Human))
Midatech

US Patent

BDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)

IC50: 4.97nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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B.MOAD DrugBank antibodypedia GoogleScholar

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Histone deacetylase 3(Homo sapiens (Human))
Midatech

US Patent

BDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)

IC50: 0.751nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Histone deacetylase 4(Homo sapiens (Human))
Midatech

US Patent

BDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)

IC50: 1.55E+3nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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B.MOAD DrugBank antibodypedia GoogleScholar

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Histone deacetylase 5(Homo sapiens (Human))
Midatech

US Patent

BDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)

IC50: 166nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair

Reactome pathway KEGG
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Histone deacetylase 6(Homo sapiens (Human))
Midatech

US Patent

BDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)

IC50: 1.77nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 7(Homo sapiens (Human))
Midatech

US Patent

BDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)

IC50: 3.68E+3nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Histone deacetylase 8(Homo sapiens (Human))
Midatech

US Patent

BDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)

IC50: 51.9nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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B.MOAD DrugBank antibodypedia GoogleScholar

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Histone deacetylase 9(Homo sapiens (Human))
Midatech

US Patent

BDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)

IC50: 1.04E+3nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair

Reactome pathway KEGG
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Polyamine deacetylase HDAC10(Homo sapiens (Human))
Midatech

US Patent

BDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)

IC50: 12.7nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
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Histone deacetylase 11(Homo sapiens (Human))
Midatech

US Patent

BDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)

IC50: 1.67E+3nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
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Filter my 207 hits

Targets 24▿
- Histone deacetylase 1 28
- Histone deacetylase 6 23
- Histone deacetylase 8 19
- Histone deacetylase 2 18
- Histone deacetylase 3 17
- Histone deacetylase 4 16
- Histone deacetylase 5 14
- Histone deacetylase 9 13
- Histone deacetylase 7 13
- Polyamine deacetylase HDAC10 9
- Histone deacetylase 11 9
- Histone deacetylase 7
- Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) 6
- Leukotriene A-4 hydrolase 2
- NAD-dependent protein deacetylase sirtuin-2 2
- NAD-dependent protein deacetylase sirtuin-1 2
- NAD-dependent protein deacetylase sirtuin-3, mitochondrial 2
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- Bromodomain-containing protein 4 1
- NAD-dependent protein deacetylase sirtuin-7 1
- Histone deacetylase 1/2/3/8 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- Protein Tat 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
- ...
Publications 33▿
- J Med Chem 63: 5501-5525 (2020) 21
- J Med Chem 59: 5488-504 (2016) 16
- Bioorg Med Chem Lett 28: 2985-2992 (2018) 16
- J Med Chem 63: 804-815 (2020) 14
- J Med Chem 54: 4694-720 (2011) 12
- J Med Chem 62: 3171-3183 (2019) 11
- US Patent US10722597 (2020) 11
- J Med Chem 59: 1455-70 (2016) 11
- ACS Chem Biol 11: 363-74 (2016) 9
- Bioorg Med Chem 24: 4008-4015 (2016) 9
- Bioorg Med Chem 23: 5151-5 (2015) 9
- J Med Chem 65: 285-302 (2022) 7
- Bioorg Med Chem 27: (2019) 6
- Drug Metab Dispos 40: 1041-50 (2012) 6
- J Med Chem 63: 23-39 (2020) 4
- J Med Chem 64: 3392-3426 (2021) 4
- Eur J Med Chem 127: 531-553 (2017) 4
- J Med Chem 65: 3080-3097 (2022) 4
- J Med Chem 59: 8967-9004 (2016) 4
- Bioorg Med Chem Lett 29: 2581-2586 (2019) 3
- J Med Chem 64: 15379-15401 (2021) 2
- J Med Chem 60: 1817-1828 (2017) 2
- Bioorg Med Chem 25: 2105-2132 (2017) 1
- J Med Chem 60: 4780-4804 (2017) 1
- Eur J Med Chem 220: (2021) 1
- Bioorg Med Chem Lett 23: 3200-3 (2013) 1
- Eur J Med Chem 229: (2022) 1
- Bioorg Med Chem Lett 27: 4051-4055 (2017) 1
- Bioorg Med Chem Lett 29: 2136-2140 (2019) 1
- J Med Chem 52: 2185-7 (2009) 1
- J Med Chem 63: 10339-10351 (2020) 1
- Eur J Med Chem 183: (2019) 1
- J Med Chem 62: 5148-5175 (2019) 1
Institutions 29▿
- Ocean University Of China 28
- West China Hospital Of Sichuan University 18
- Nestle Skin Health R&D 16
- Chinese Academy Of Sciences 14
- S*Bio 12
- Qingdao University 11
- Midatech 11
- Sichuan University 11
- Broad Institute Of Mit And Harvard 9
- St. Jude Children'S Research Hospital 9
- Broad Institute of Harvard and Mit 9
- University Of Navarra 8
- Novartis Institutes For Biomedical Research 6
- Heinrich-Heine-University D£Sseldorf 6
- Washington University 5
- University Of Naples "Federico Ii 4
- University Of Naples Federico Ii 4
- The University Of Sydney 3
- East China University Of Science And Technology 2
- The Walter And Eliza Hall Institute For Medical Research 1
- Central South University 1
- Chongqing Medical University 1
- Dipartimento Di Chimica E Tecnologie Del Farmaco "Sapienza" Universit£ 1
- Leipzig University 1
- Harvard Medical School 1
- Hunan University Of Science And Technology 1
- Sichuan Academy Of Medical Science&Sichuan Provincial People'S Hospital 1
- Sichuan University and Collaborative Innovation Center 1
- Xinxiang Medical University 1
Affinity: 0.5 to 2.0E+4 nM▿
- Ki 40
- IC50 165
- EC50 2
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1