BDBM50021954 (2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::(S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid::3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam)::CHEMBL403::CP-45,899::SULBACTAM::UNASYN::US20230322715, Compound ALK-09::US9120808, Sulbactam sodium salt
SMILES CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O
InChI Key InChIKey=FKENQMMABCRJMK-RITPCOANSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 56 hits for monomerid = 50021954
Affinity DataKi: 800nMAssay Description:Inhibition constant (Ki) for TEM-1 beta-lactamaseMore data for this Ligand-Target Pair
TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Case Western Reserve University
Case Western Reserve University
Affinity DataKi: 1.50E+3nM IC50: 3.40E+3nMpH: 7.4Assay Description:Steady state kinetics were performed on an Agilent 8453 diode array spectrophotometer in 10 mM phosphate-buffered saline (pH 7.4). IC50, defined as t...More data for this Ligand-Target Pair
Affinity DataKi: 1.67E+5nMAssay Description:Inhibition of Klebsiella pneumoniae 1534 beta-lactamase KPC-2 by competitive assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of Beta-lactamase of Bacillus cereus (class A enzyme) without preincubationMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Compound was evaluated for beta-lactamase inhibition activity of Escherichia coli after 15 min of preincubation with the enzyme at 37 degree CMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Compound was evaluated for beta-lactamase inhibition activity of Escherichia cloacae after 15 min of preincubation with the enzyme at 37 degree CMore data for this Ligand-Target Pair
Affinity DataIC50: 6.59E+4nMAssay Description:Inhibitory activity of the compound against AmpC (class C) beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory activity of the compound against TEM-1 (class A) beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataIC50: 6.59E+4nMAssay Description:Inhibitory activity of the compound against AmpC (class C) beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory activity of the compound against TEM-1 (class A) beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibitory activity against Beta-lactamase type OXA1 (penicillinase) from E. coli OXA1 using ampicillin (40 uM) as a substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+5nMAssay Description:Inhibitory activity against Beta-lactamase type TEM2 (penicillinase) from E. coli TEM2 using penicillin G (40 uM) as a substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibitory activity against Penicillinase from Staphylococcus aureus TH-14 using piperacillin (40 uM) as a substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60E+4nMAssay Description:In vitro inhibitory concentration against AmpC enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibitory concentration against TEM-1 enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibitory concentration against CCRA enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibitory activity against Beta-lactamase TEM-1 of class A enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60E+4nMAssay Description:In vitro inhibitory activity against Beta-lactamase AmpC of class C enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 2.27E+4nMAssay Description:Inhibition of Serratia fonticola UTAD54 SFC1 beta lactamase expressed in Escherichia coli BL21(DE3) by SDS-PAGEMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of Escherichia coli beta-lactamase ACC4More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of Brachyspira pilosicoli beta-lactamase OXA-63 expressed in Escherichia coli BL21 (DE3) assessed as reduction in nitrocefin hydrolysis by...More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of Pseudomonas aeruginosa GES-13 beta lactamaseMore data for this Ligand-Target Pair
TargetBeta-lactamase(Acinetobacter genomosp. 3)
Complejo Hospitalario Universitario Juan Canalejo-Inibic
Curated by ChEMBL
Complejo Hospitalario Universitario Juan Canalejo-Inibic
Curated by ChEMBL
Affinity DataIC50: 7.76E+3nMAssay Description:Inhibition of Acinetobacter genomosp. 3 isolate 103 ADC-16More data for this Ligand-Target Pair
TargetBeta-lactamase(Acinetobacter genomosp. 3)
Complejo Hospitalario Universitario Juan Canalejo-Inibic
Curated by ChEMBL
Complejo Hospitalario Universitario Juan Canalejo-Inibic
Curated by ChEMBL
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of Acinetobacter genomosp. 3 isolate 65 ADC-14More data for this Ligand-Target Pair
TargetBeta-lactamase(Acinetobacter genomosp. 3)
Complejo Hospitalario Universitario Juan Canalejo-Inibic
Curated by ChEMBL
Complejo Hospitalario Universitario Juan Canalejo-Inibic
Curated by ChEMBL
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of Acinetobacter genomosp. 3 isolate 195 ADC-18More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of Escherichia coli JM109 beta-lactamase SHV-11More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of Aeromonas allosaccharophila AL-1 beta-lactamase PER6More data for this Ligand-Target Pair
Affinity DataIC50: 2.11E+4nMAssay Description:Inhibition of Enterobacter cloacae beta-lactamase P99 assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubationMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa beta-lactamase AmpC assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubationMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of Beta-lactamase of Bacillus cereus (class A enzyme) without preincubationMore data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of Escherichia coli beta-lactamase SCO1More data for this Ligand-Target Pair
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of Escherichia coli K12 TEM1More data for this Ligand-Target Pair
Affinity DataIC50: 342nMAssay Description:Inhibitory activity against Proteus vulgaris HJ33C Class-I beta-lactamase enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 3.42E+3nMAssay Description:Inhibitory activity against Enterobacter cloacae HC8 Class-I beta-lactamase enzyme type P99More data for this Ligand-Target Pair
Affinity DataIC50: 857nMAssay Description:Inhibitory activity against Citrobacter freundii 87470 Class-I beta-lactamase enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 557nMAssay Description:Inhibitory activity against Escherichia coli HA58R Class-III TEM-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
TargetBeta-lactamase SHV-1(Pseudomonas aeruginosa (g-Proteobacteria))
Case Western Reserve University
Case Western Reserve University
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibitory activity against Escherichia coli HA208 Class-III SHV-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 3.42E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus CJ8 beta-lactamase enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 2.14E+3nMAssay Description:Inhibitory activity against Bacteroides fragilis 88854 Class-I beta-lactamase enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibitory activity against Escherichia coli HA209 Class-V OXA-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibitory activity against Klebsiella oxytoca HC7 Class-IV K1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 107nMAssay Description:Inhibitory activity against Branhamella catarrhalis 89001 Class-III BRO-1 type beta-lactamase enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against Beta-lactamase type TEM2 (penicillinase) from E. coli TEM2 using penicillin G (40 uM) as a substrateMore data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa 51170 beta-lactamase BEL-1More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa 531 beta-lactamase BEL-2More data for this Ligand-Target Pair