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Found 48 with Last Name = 'jaton' and Initial = 'al'
TargetCathepsin E(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305527((4S)-4-[(1R)-1-hydroxy-2-({1-[3-(1-methylethyl)phe...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50294218((3S,14R,16S)-16-((R)-1-hydroxy-2-((S)-6-isopropyl-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305544((S)-4-{(R)-1-Hydroxy-2-[1-(3-isopropyl-phenyl)-cyc...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305542(CHEMBL595016 | Propane-1-sulfonic acid{(S)-4-[(R)-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305527((4S)-4-[(1R)-1-hydroxy-2-({1-[3-(1-methylethyl)phe...)
Affinity DataIC50:  1nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305531(CHEMBL595136 | Propane-1-sulfonic acid((S)-4-{(R)-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50294218((3S,14R,16S)-16-((R)-1-hydroxy-2-((S)-6-isopropyl-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305536((S)-4-{(R)-1-Hydroxy-2-[1-(3-isopropyl-phenyl)-cyc...)
Affinity DataIC50:  3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305537((S)-4-{(R)-1-Hydroxy-2-[1-(3-isopropyl-phenyl)-cyc...)
Affinity DataIC50:  4nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305536((S)-4-{(R)-1-Hydroxy-2-[1-(3-isopropyl-phenyl)-cyc...)
Affinity DataIC50:  5nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305533((S)-4-[(R)-1-Hydroxy-2-(3-isopropyl-benzylamino)-e...)
Affinity DataIC50:  8nMAssay Description:Inhibition of cathepsin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305536((S)-4-{(R)-1-Hydroxy-2-[1-(3-isopropyl-phenyl)-cyc...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305537((S)-4-{(R)-1-Hydroxy-2-[1-(3-isopropyl-phenyl)-cyc...)
Affinity DataIC50:  11nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305527((4S)-4-[(1R)-1-hydroxy-2-({1-[3-(1-methylethyl)phe...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305537((S)-4-{(R)-1-Hydroxy-2-[1-(3-isopropyl-phenyl)-cyc...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305543((S)-4-[(R)-1-Hydroxy-2-(3-isopropyl-benzylamino)-e...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305527((4S)-4-[(1R)-1-hydroxy-2-({1-[3-(1-methylethyl)phe...)
Affinity DataIC50:  20nMAssay Description:Inhibition of BACE1 expressed in APP-overexpressing CHO cellsMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50294219((3S,14R,16S)-16-((R)-1-hydroxy-2-(3-isopropylbenzy...)
Affinity DataIC50:  27nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305534((S)-4-[(R)-1-Hydroxy-2-(3-isopropyl-benzylamino)-e...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305533((S)-4-[(R)-1-Hydroxy-2-(3-isopropyl-benzylamino)-e...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50294219((3S,14R,16S)-16-((R)-1-hydroxy-2-(3-isopropylbenzy...)
Affinity DataIC50:  45nMAssay Description:Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregationMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305536((S)-4-{(R)-1-Hydroxy-2-[1-(3-isopropyl-phenyl)-cyc...)
Affinity DataIC50:  47nMAssay Description:Inhibition of BACE1 expressed in APP-overexpressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305530((S)-4-{(R)-1-Hydroxy-2-[1-(3-isopropyl-phenyl)-1-m...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305528((S)-4-{(R)-2-[1-(3-tert-Butyl-phenyl)-cyclopentyla...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305533((S)-4-[(R)-1-Hydroxy-2-(3-isopropyl-benzylamino)-e...)
Affinity DataIC50:  55nMAssay Description:Inhibition of BACE1 expressed in APP-overexpressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305535((S)-4-[(R)-1-Hydroxy-2-(3-isopropyl-benzylamino)-e...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305529((S)-4-{(R)-2-[1-(3-tert-Butyl-phenyl)-cyclobutylam...)
Affinity DataIC50:  67nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305537((S)-4-{(R)-1-Hydroxy-2-[1-(3-isopropyl-phenyl)-cyc...)
Affinity DataIC50:  70nMAssay Description:Inhibition of BACE1 expressed in APP-overexpressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305540((S)-4-{(R)-1-Hydroxy-2-[1-(3-isopropyl-phenyl)-eth...)
Affinity DataIC50:  83nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29754(macrocyclic peptidomimetic, 3h)
Affinity DataIC50:  150nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305533((S)-4-[(R)-1-Hydroxy-2-(3-isopropyl-benzylamino)-e...)
Affinity DataIC50:  156nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305539((S)-4-{(R)-2-[1-(3-tert-Butyl-phenyl)-2-fluoro-eth...)
Affinity DataIC50:  177nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29750(macrocyclic peptidomimetic, 3d)
Affinity DataIC50:  250nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305532((S)-4-[(R)-1-Hydroxy-2-(3-isopropyl-benzylamino)-e...)
Affinity DataIC50:  292nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29744(hydroxyethylene tripeptide inhibitor, 1)
Affinity DataIC50:  370nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29748(NVP-ARV99 | macrocyclic peptidomimetic, 3b)
Affinity DataIC50:  590nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305541((S)-4-{(R)-2-[1-(3-tert-Butyl-phenyl)-2-methoxy-et...)
Affinity DataIC50:  668nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29744(hydroxyethylene tripeptide inhibitor, 1)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50294219((3S,14R,16S)-16-((R)-1-hydroxy-2-(3-isopropylbenzy...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29750(macrocyclic peptidomimetic, 3d)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29754(macrocyclic peptidomimetic, 3h)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29754(macrocyclic peptidomimetic, 3h)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29748(NVP-ARV99 | macrocyclic peptidomimetic, 3b)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregationMore data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29748(NVP-ARV99 | macrocyclic peptidomimetic, 3b)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29750(macrocyclic peptidomimetic, 3d)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM29744(hydroxyethylene tripeptide inhibitor, 1)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregationMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305538((S)-4-{(R)-2-[1-(3-tert-Butyl-phenyl)-2,2,2-triflu...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant BACE1 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50294218((3S,14R,16S)-16-((R)-1-hydroxy-2-((S)-6-isopropyl-...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregationMore data for this Ligand-Target Pair