Compile Data Set for Download or QSAR
maximum 50k data
Found 78 with Last Name = 'melin' and Initial = 'jc'
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50278495(4-chloro-1-(4-(3-(piperidin-1-yl)propoxy)benzyl)pi...)
Affinity DataKi:  0.0680nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50278350(4-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)benzyl)pi...)
Affinity DataKi:  0.0940nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  0.160nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50403879(CHEMBL320217)
Affinity DataKi:  0.170nMAssay Description:Tested for inhibitory activity against thymidylate synthase of L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50278449(4-bromo-1-(4-(3-(piperidin-1-yl)propoxy)benzyl)pip...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50088159(4-[3-Carboxy-1-(1H-tetrazol-5-yl)-propylcarbamoyl]...)
Affinity DataKi:  0.200nMAssay Description:Tested for inhibitory activity against thymidylate synthase of L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50278448(4,4-difluoro-1-(4-(3-(piperidin-1-yl)propoxy)benzy...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50278445(4-fluoro-1-(4-(3-(pyrrolidin-1-yl)propoxy)benzyl)p...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50278400((S)-1-(3-(4-((3-fluoropyrrolidin-1-yl)methyl)pheno...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50278444((R)-1-(3-(4-((3-fluoropyrrolidin-1-yl)methyl)pheno...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50278446((R)-3-fluoro-1-(4-(3-(pyrrolidin-1-yl)propoxy)benz...)
Affinity DataKi:  0.310nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50403876(CHEMBL323098)
Affinity DataKi:  0.330nMAssay Description:Tested for inhibitory activity against thymidylate synthase of L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50088161(2-(4-Carboxy-4-{4-[(2-methyl-4-oxo-4,6,7,8-tetrahy...)
Affinity DataKi:  0.420nMAssay Description:Tested for inhibitory activity against thymidylate synthase of L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  0.580nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50403877(CHEMBL103105)
Affinity DataKi:  0.710nMAssay Description:Tested for inhibitory activity against thymidylate synthase of L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50088164((S)-2-{4-[(2-Methyl-4-oxo-4,6,7,8-tetrahydro-3H-cy...)
Affinity DataKi:  0.780nMAssay Description:Tested for inhibitory activity against thymidylate synthase of L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50278496(1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidin-4...)
Affinity DataKi:  0.840nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50278447(4-fluoro-1-(3-(4-(pyrrolidin-1-ylmethyl)phenoxy)pr...)
Affinity DataKi:  0.990nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50403878(CHEMBL320651)
Affinity DataKi:  2.10nMAssay Description:Tested for inhibitory activity against thymidylate synthase of L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50378000(CHEMBL1202078)
Affinity DataKi:  2.40nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [125I]iodoproxyfan human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in rat C6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50126888(1-[4-(4-Piperidin-1-ylmethyl-benzyloxy)-benzyl]-pi...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50377994(CHEMBL1202072)
Affinity DataKi:  3.20nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50377996(CHEMBL1202074)
Affinity DataKi:  3.5nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50403880(CHEMBL317717)
Affinity DataKi:  3.5nMAssay Description:Tested for inhibitory activity against thymidylate synthase of L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50377990(CHEMBL1202068)
Affinity DataKi:  7.20nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50327227(4,5-diphenyl-2-(3-(piperidin-1-yl)propylthio)thiaz...)
Affinity DataKi:  7.40nMAssay Description:Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50377999(CHEMBL1202077)
Affinity DataKi:  7.70nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50133003(4-(3-(piperidin-1-yl)propoxy)benzonitrile | 4-(3-P...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50327232(4,5-diphenyl-2-(3-(piperidin-1-yl)propoxy)thiazole...)
Affinity DataKi:  11.2nMAssay Description:Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50327232(4,5-diphenyl-2-(3-(piperidin-1-yl)propoxy)thiazole...)
Affinity DataKi:  11.2nMAssay Description:Displacement of [125I]iodoproxyfan human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50377989(CHEMBL1202067)
Affinity DataKi:  12.5nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50377997(CHEMBL1202075)
Affinity DataKi:  12.8nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50327314(5-ethyl-2-(3-(piperidin-1-yl)propoxy)-4,5,6,7-tetr...)
Affinity DataKi:  14nMAssay Description:Displacement of [125I]iodoproxyfan human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  14.8nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  17nMAssay Description:Binding affinity to histamine H3 receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50278398(1-(3-(4-(fluoromethyl)phenoxy)propyl)piperidine | ...)
Affinity DataKi:  17.3nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50377993(CHEMBL1202071)
Affinity DataKi:  18.6nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50327233(2-(3-(piperidin-1-yl)propoxy)-5-(3-(piperidin-1-yl...)
Affinity DataKi:  20nMAssay Description:Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50008294(2-(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)m...)
Affinity DataKi:  20nMAssay Description:Tested for inhibitory activity against thymidylate synthase of L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50327316(2-(3-(piperidin-1-yl)propoxy)-5-(3-(piperidin-1-yl...)
Affinity DataKi:  20nMAssay Description:Displacement of [125I]iodoproxyfan human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50327313(5-methyl-2-(3-(piperidin-1-yl)propoxy)-4,5,6,7-tet...)
Affinity DataKi:  24nMAssay Description:Displacement of [125I]iodoproxyfan human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50377991(CHEMBL1202069)
Affinity DataKi:  27.3nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50377995(CHEMBL1202073)
Affinity DataKi:  27.9nMAssay Description:Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50327229(4,5-diphenyl-2-(3-(piperidin-1-yl)propylthio)oxazo...)
Affinity DataKi:  32nMAssay Description:Displacement of [125I]Iodoproxyfan from human histamine H3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johann Wolfgang Goethe-UniversitäT

Curated by ChEMBL
LigandPNGBDBM50327320(4-methyl-5-phenyl-2-(3-(piperidin-1-yl)propoxy)thi...)
Affinity DataKi:  41nMAssay Description:Displacement of [125I]iodoproxyfan human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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