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Compile Data Set for Download or QSAR

Found 59 hits Enz. Inhib. hit(s) with all data for entry = 50035302   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Progesterone receptor


(Homo sapiens (Human))
BDBM50129152
PNG
((6S,8S,10R,14S,15S)-17-Acetyl-6,10-dimethyl-13-(R)...)
Show SMILES C[C@H]1CC2[C@@H]3CC[C@](CC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C25H36O3/c1-15-12-19-20(23(4)9-6-18(28)13-22(15)23)7-10-24(5)21(19)8-11-25(24,17(3)27)14-16(2)26/h13,15,19-21H,6-12,14H2,1-5H3/t15-,19?,20-,21-,23+,24-,25-/m0/s1
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0.340n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50067684
PNG
(2,2,4-Trimethyl-5-[1-o-tolyl-meth-(Z)-ylidene]-2,5...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4ccccc4O\C(=C/c4ccccc4C)c3c12
Show InChI InChI=1S/C27H25NO/c1-17-9-5-6-10-19(17)15-24-26-21(20-11-7-8-12-23(20)29-24)13-14-22-25(26)18(2)16-27(3,4)28-22/h5-16,28H,1-4H3/b24-15-
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0.660n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50129146
PNG
((Z)-5-(bromomethylene)-9-fluoro-2,2,4-trimethyl-2,...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/Br)c3c12
Show InChI InChI=1S/C20H17BrFNO/c1-11-9-20(2,3)23-15-6-5-13-14-8-12(22)4-7-16(14)24-17(10-21)19(13)18(11)15/h4-10,23H,1-3H3/b17-10-
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2.10n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129145
PNG
(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Show SMILES CC(C)=C\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
Show InChI InChI=1S/C24H24FNO/c1-14(2)6-10-21-23-17(18-12-16(25)7-11-20(18)27-21)8-9-19-22(23)15(3)13-24(4,5)26-19/h6-13,26H,1-5H3/b21-10-
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2.5n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity for human progesterone receptor; Not active


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129144
PNG
((Z)-5-butylidene-9-fluoro-2,2,4-trimethyl-2,5-dihy...)
Show SMILES CCC\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
Show InChI InChI=1S/C23H24FNO/c1-5-6-7-20-22-16(17-12-15(24)8-11-19(17)26-20)9-10-18-21(22)14(2)13-23(3,4)25-18/h7-13,25H,5-6H2,1-4H3/b20-7-
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3.10n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM8903
PNG
((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
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3.5n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50129150
PNG
(9-Fluoro-2,2,4-trimethyl-5-methylene-2,5-dihydro-1...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4OC(=C)c3c12
Show InChI InChI=1S/C20H18FNO/c1-11-10-20(3,4)22-16-7-6-14-15-9-13(21)5-8-17(15)23-12(2)19(14)18(11)16/h5-10,22H,2H2,1,3-4H3
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6.10n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129149
PNG
(5-[1,3]Dithian-2-ylidene-9-fluoro-2,2,4-trimethyl-...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4OC(=C4SCCCS4)c3c12
Show InChI InChI=1S/C23H22FNOS2/c1-13-12-23(2,3)25-17-7-6-15-16-11-14(24)5-8-18(16)26-21(20(15)19(13)17)22-27-9-4-10-28-22/h5-8,11-12,25H,4,9-10H2,1-3H3
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6.30n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129157
PNG
((Z)-5-(butan-2-ylidene)-9-fluoro-2,2,4-trimethyl-2...)
Show SMILES CC\C(C)=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
Show InChI InChI=1S/C23H24FNO/c1-6-13(2)22-21-16(17-11-15(24)7-10-19(17)26-22)8-9-18-20(21)14(3)12-23(4,5)25-18/h7-12,25H,6H2,1-5H3/b22-13-
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8n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129153
PNG
((E)-5-(butan-2-ylidene)-9-fluoro-2,2,4-trimethyl-2...)
Show SMILES CC\C(C)=C1\Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
Show InChI InChI=1S/C23H24FNO/c1-6-13(2)22-21-16(17-11-15(24)7-10-19(17)26-22)8-9-18-20(21)14(3)12-23(4,5)25-18/h7-12,25H,6H2,1-5H3/b22-13+
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17n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129151
PNG
(9-Fluoro-2,2,4-trimethyl-5-(3-methyl-2-methylene-b...)
Show SMILES CC(C)C(=C)\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
Show InChI InChI=1S/C25H26FNO/c1-14(2)15(3)11-22-24-18(19-12-17(26)7-10-21(19)28-22)8-9-20-23(24)16(4)13-25(5,6)27-20/h7-14,27H,3H2,1-2,4-6H3/b22-11-
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26n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129156
PNG
((Z)-2-(9-fluoro-2,2,4-trimethyl-1,2-dihydrochromen...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/C#N)c3c12
Show InChI InChI=1S/C21H17FN2O/c1-12-11-21(2,3)24-16-6-5-14-15-10-13(22)4-7-17(15)25-18(8-9-23)20(14)19(12)16/h4-8,10-11,24H,1-3H3/b18-8-
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45n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129155
PNG
(5-diphenylmethylene-2,2,4-trimethyl-2,5-dihydro-1H...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4OC(=C(c4ccccc4)c4ccccc4)c3c12
Show InChI InChI=1S/C32H26FNO/c1-20-19-32(2,3)34-26-16-15-24-25-18-23(33)14-17-27(25)35-31(30(24)28(20)26)29(21-10-6-4-7-11-21)22-12-8-5-9-13-22/h4-19,34H,1-3H3
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>100n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129154
PNG
(1-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-az...)
Show SMILES CC(=O)C=C1Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
Show InChI InChI=1S/C22H20FNO2/c1-12-11-22(3,4)24-17-7-6-15-16-10-14(23)5-8-18(16)26-19(9-13(2)25)21(15)20(12)17/h5-11,24H,1-4H3
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>100n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129147
PNG
(5-Cyclohexylmethylene-9-fluoro-2,2,4-trimethyl-2,5...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/C4CCCCC4)c3c12
Show InChI InChI=1S/C26H28FNO/c1-16-15-26(2,3)28-21-11-10-19-20-14-18(27)9-12-22(20)29-23(25(19)24(16)21)13-17-7-5-4-6-8-17/h9-15,17,28H,4-8H2,1-3H3/b23-13-
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>100n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129148
PNG
(CHEMBL65689 | [9-Fluoro-2,2,4-trimethyl-1,2-dihydr...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/C=O)c3c12
Show InChI InChI=1S/C21H18FNO2/c1-12-11-21(2,3)23-16-6-5-14-15-10-13(22)4-7-17(15)25-18(8-9-24)20(14)19(12)16/h4-11,23H,1-3H3/b18-8-
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>100n/an/an/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Androgen Receptor


(Homo sapiens (human))
BDBM50129152
PNG
((6S,8S,10R,14S,15S)-17-Acetyl-6,10-dimethyl-13-(R)...)
Show SMILES C[C@H]1CC2[C@@H]3CC[C@](CC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C25H36O3/c1-15-12-19-20(23(4)9-6-18(28)13-22(15)23)7-10-24(5)21(19)8-11-25(24,17(3)27)14-16(2)26/h13,15,19-21H,6-12,14H2,1-5H3/t15-,19?,20-,21-,23+,24-,25-/m0/s1
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n/an/a 6.10n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity against Androgen receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50129152
PNG
((6S,8S,10R,14S,15S)-17-Acetyl-6,10-dimethyl-13-(R)...)
Show SMILES C[C@H]1CC2[C@@H]3CC[C@](CC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C25H36O3/c1-15-12-19-20(23(4)9-6-18(28)13-22(15)23)7-10-24(5)21(19)8-11-25(24,17(3)27)14-16(2)26/h13,15,19-21H,6-12,14H2,1-5H3/t15-,19?,20-,21-,23+,24-,25-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid (hGR) receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM8903
PNG
((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at mineralocorticoid receptor (hMR)


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Androgen Receptor


(Homo sapiens (human))
BDBM8903
PNG
((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
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n/an/a 37n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity against Androgen receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129156
PNG
((Z)-2-(9-fluoro-2,2,4-trimethyl-1,2-dihydrochromen...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/C#N)c3c12
Show InChI InChI=1S/C21H17FN2O/c1-12-11-21(2,3)24-16-6-5-14-15-10-13(22)4-7-17(15)25-18(8-9-23)20(14)19(12)16/h4-8,10-11,24H,1-3H3/b18-8-
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n/an/a 65n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129154
PNG
(1-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-az...)
Show SMILES CC(=O)C=C1Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
Show InChI InChI=1S/C22H20FNO2/c1-12-11-22(3,4)24-17-7-6-15-16-10-14(23)5-8-18(16)26-19(9-13(2)25)21(15)20(12)17/h5-11,24H,1-4H3
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n/an/a 124n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50129149
PNG
(5-[1,3]Dithian-2-ylidene-9-fluoro-2,2,4-trimethyl-...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4OC(=C4SCCCS4)c3c12
Show InChI InChI=1S/C23H22FNOS2/c1-13-12-23(2,3)25-17-7-6-15-16-11-14(24)5-8-18(16)26-21(20(15)19(13)17)22-27-9-4-10-28-22/h5-8,11-12,25H,4,9-10H2,1-3H3
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n/an/a 146n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50129145
PNG
(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Show SMILES CC(C)=C\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
Show InChI InChI=1S/C24H24FNO/c1-14(2)6-10-21-23-17(18-12-16(25)7-11-20(18)27-21)8-9-19-22(23)15(3)13-24(4,5)26-19/h6-13,26H,1-5H3/b21-10-
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n/an/a 177n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid (hGR) receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50129149
PNG
(5-[1,3]Dithian-2-ylidene-9-fluoro-2,2,4-trimethyl-...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4OC(=C4SCCCS4)c3c12
Show InChI InChI=1S/C23H22FNOS2/c1-13-12-23(2,3)25-17-7-6-15-16-11-14(24)5-8-18(16)26-21(20(15)19(13)17)22-27-9-4-10-28-22/h5-8,11-12,25H,4,9-10H2,1-3H3
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n/an/a 180n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity against human Androgen receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129148
PNG
(CHEMBL65689 | [9-Fluoro-2,2,4-trimethyl-1,2-dihydr...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/C=O)c3c12
Show InChI InChI=1S/C21H18FNO2/c1-12-11-21(2,3)23-16-6-5-14-15-10-13(22)4-7-17(15)25-18(8-9-24)20(14)19(12)16/h4-11,23H,1-3H3/b18-8-
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n/an/a 243n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50129157
PNG
((Z)-5-(butan-2-ylidene)-9-fluoro-2,2,4-trimethyl-2...)
Show SMILES CC\C(C)=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
Show InChI InChI=1S/C23H24FNO/c1-6-13(2)22-21-16(17-11-15(24)7-10-19(17)26-22)8-9-18-20(21)14(3)12-23(4,5)25-18/h7-12,25H,6H2,1-5H3/b22-13-
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n/an/a 250n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity against human Androgen receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50129146
PNG
((Z)-5-(bromomethylene)-9-fluoro-2,2,4-trimethyl-2,...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/Br)c3c12
Show InChI InChI=1S/C20H17BrFNO/c1-11-9-20(2,3)23-15-6-5-13-14-8-12(22)4-7-16(14)24-17(10-21)19(13)18(11)15/h4-10,23H,1-3H3/b17-10-
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n/an/a 250n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity against Androgen receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50129157
PNG
((Z)-5-(butan-2-ylidene)-9-fluoro-2,2,4-trimethyl-2...)
Show SMILES CC\C(C)=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
Show InChI InChI=1S/C23H24FNO/c1-6-13(2)22-21-16(17-11-15(24)7-10-19(17)26-22)8-9-18-20(21)14(3)12-23(4,5)25-18/h7-12,25H,6H2,1-5H3/b22-13-
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n/an/a 324n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50129149
PNG
(5-[1,3]Dithian-2-ylidene-9-fluoro-2,2,4-trimethyl-...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4OC(=C4SCCCS4)c3c12
Show InChI InChI=1S/C23H22FNOS2/c1-13-12-23(2,3)25-17-7-6-15-16-11-14(24)5-8-18(16)26-21(20(15)19(13)17)22-27-9-4-10-28-22/h5-8,11-12,25H,4,9-10H2,1-3H3
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n/an/a 631n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50129149
PNG
(5-[1,3]Dithian-2-ylidene-9-fluoro-2,2,4-trimethyl-...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4OC(=C4SCCCS4)c3c12
Show InChI InChI=1S/C23H22FNOS2/c1-13-12-23(2,3)25-17-7-6-15-16-11-14(24)5-8-18(16)26-21(20(15)19(13)17)22-27-9-4-10-28-22/h5-8,11-12,25H,4,9-10H2,1-3H3
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n/an/a 681n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at mineralocorticoid receptor (hMR)


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129147
PNG
(5-Cyclohexylmethylene-9-fluoro-2,2,4-trimethyl-2,5...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/C4CCCCC4)c3c12
Show InChI InChI=1S/C26H28FNO/c1-16-15-26(2,3)28-21-11-10-19-20-14-18(27)9-12-22(20)29-23(25(19)24(16)21)13-17-7-5-4-6-8-17/h9-15,17,28H,4-8H2,1-3H3/b23-13-
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n/an/a 800n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129153
PNG
((E)-5-(butan-2-ylidene)-9-fluoro-2,2,4-trimethyl-2...)
Show SMILES CC\C(C)=C1\Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
Show InChI InChI=1S/C23H24FNO/c1-6-13(2)22-21-16(17-11-15(24)7-10-19(17)26-22)8-9-18-20(21)14(3)12-23(4,5)25-18/h7-12,25H,6H2,1-5H3/b22-13+
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n/an/a 980n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human progesterone receptor


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50129146
PNG
((Z)-5-(bromomethylene)-9-fluoro-2,2,4-trimethyl-2,...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/Br)c3c12
Show InChI InChI=1S/C20H17BrFNO/c1-11-9-20(2,3)23-15-6-5-13-14-8-12(22)4-7-16(14)24-17(10-21)19(13)18(11)15/h4-10,23H,1-3H3/b17-10-
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at mineralocorticoid receptor (hMR); not active


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM8903
PNG
((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid (hGR) receptor; not active


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50129152
PNG
((6S,8S,10R,14S,15S)-17-Acetyl-6,10-dimethyl-13-(R)...)
Show SMILES C[C@H]1CC2[C@@H]3CC[C@](CC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C25H36O3/c1-15-12-19-20(23(4)9-6-18(28)13-22(15)23)7-10-24(5)21(19)8-11-25(24,17(3)27)14-16(2)26/h13,15,19-21H,6-12,14H2,1-5H3/t15-,19?,20-,21-,23+,24-,25-/m0/s1
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Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at mineralocorticoid receptor (hMR); not active


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Mineralocorticoid receptor (MR)


(Homo sapiens (Human))
BDBM50129145
PNG
(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Show SMILES CC(C)=C\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
Show InChI InChI=1S/C24H24FNO/c1-14(2)6-10-21-23-17(18-12-16(25)7-11-20(18)27-21)8-9-19-22(23)15(3)13-24(4,5)26-19/h6-13,26H,1-5H3/b21-10-
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at mineralocorticoid receptor (hMR); not active


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50129146
PNG
((Z)-5-(bromomethylene)-9-fluoro-2,2,4-trimethyl-2,...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/Br)c3c12
Show InChI InChI=1S/C20H17BrFNO/c1-11-9-20(2,3)23-15-6-5-13-14-8-12(22)4-7-16(14)24-17(10-21)19(13)18(11)15/h4-10,23H,1-3H3/b17-10-
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity at glucocorticoid (hGR) receptor; not active


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM8903
PNG
((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50129152
PNG
((6S,8S,10R,14S,15S)-17-Acetyl-6,10-dimethyl-13-(R)...)
Show SMILES C[C@H]1CC2[C@@H]3CC[C@](CC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
Show InChI InChI=1S/C25H36O3/c1-15-12-19-20(23(4)9-6-18(28)13-22(15)23)7-10-24(5)21(19)8-11-25(24,17(3)27)14-16(2)26/h13,15,19-21H,6-12,14H2,1-5H3/t15-,19?,20-,21-,23+,24-,25-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against human Estrogen receptor; not active


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50129145
PNG
(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Show SMILES CC(C)=C\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
Show InChI InChI=1S/C24H24FNO/c1-14(2)6-10-21-23-17(18-12-16(25)7-11-20(18)27-21)8-9-19-22(23)15(3)13-24(4,5)26-19/h6-13,26H,1-5H3/b21-10-
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against human Estrogen receptor; not active


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Androgen Receptor


(Homo sapiens (human))
BDBM50129145
PNG
(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Show SMILES CC(C)=C\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12
Show InChI InChI=1S/C24H24FNO/c1-14(2)6-10-21-23-17(18-12-16(25)7-11-20(18)27-21)8-9-19-22(23)15(3)13-24(4,5)26-19/h6-13,26H,1-5H3/b21-10-
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity against Androgen receptor; not active


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM50129146
PNG
((Z)-5-(bromomethylene)-9-fluoro-2,2,4-trimethyl-2,...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/Br)c3c12
Show InChI InChI=1S/C20H17BrFNO/c1-11-9-20(2,3)23-15-6-5-13-14-8-12(22)4-7-16(14)24-17(10-21)19(13)18(11)15/h4-10,23H,1-3H3/b17-10-
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n/an/a>1.00E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory activity against human Estrogen receptor; not active


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129155
PNG
(5-diphenylmethylene-2,2,4-trimethyl-2,5-dihydro-1H...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4OC(=C(c4ccccc4)c4ccccc4)c3c12
Show InChI InChI=1S/C32H26FNO/c1-20-19-32(2,3)34-26-16-15-24-25-18-23(33)14-17-27(25)35-31(30(24)28(20)26)29(21-10-6-4-7-11-21)22-12-8-5-9-13-22/h4-19,34H,1-3H3
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n/an/a 1.93E+3n/an/an/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129150
PNG
(9-Fluoro-2,2,4-trimethyl-5-methylene-2,5-dihydro-1...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4OC(=C)c3c12
Show InChI InChI=1S/C20H18FNO/c1-11-10-20(3,4)22-16-7-6-14-15-9-13(21)5-8-17(15)23-12(2)19(14)18(11)16/h5-10,22H,2H2,1,3-4H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129156
PNG
((Z)-2-(9-fluoro-2,2,4-trimethyl-1,2-dihydrochromen...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/C#N)c3c12
Show InChI InChI=1S/C21H17FN2O/c1-12-11-21(2,3)24-16-6-5-14-15-10-13(22)4-7-17(15)25-18(8-9-23)20(14)19(12)16/h4-8,10-11,24H,1-3H3/b18-8-
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n/an/an/an/a 2.70E+3n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129149
PNG
(5-[1,3]Dithian-2-ylidene-9-fluoro-2,2,4-trimethyl-...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4OC(=C4SCCCS4)c3c12
Show InChI InChI=1S/C23H22FNOS2/c1-13-12-23(2,3)25-17-7-6-15-16-11-14(24)5-8-18(16)26-21(20(15)19(13)17)22-27-9-4-10-28-22/h5-8,11-12,25H,4,9-10H2,1-3H3
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n/an/an/an/a 2.10n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50129147
PNG
(5-Cyclohexylmethylene-9-fluoro-2,2,4-trimethyl-2,5...)
Show SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/C4CCCCC4)c3c12
Show InChI InChI=1S/C26H28FNO/c1-16-15-26(2,3)28-21-11-10-19-20-14-18(27)9-12-22(20)29-23(25(19)24(16)21)13-17-7-5-4-6-8-17/h9-15,17,28H,4-8H2,1-3H3/b23-13-
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n/an/an/an/a 48n/an/an/an/a



Ligand Pharmaceuticals

Curated by ChEMBL


Assay Description
Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells


Bioorg Med Chem Lett 13: 2071-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00255-5
BindingDB Entry DOI: 10.7270/Q2SX6DSM
More data for this
Ligand-Target Pair
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