Compile Data Set for Download or QSAR
maximum 50k data
Found 940 of ic50 for UniProtKB: P26684
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105051(CHEMBL112624 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50:  0.0150nMAssay Description:Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105051(CHEMBL112624 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50:  0.0150nMAssay Description:Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143792(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143796(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50532607(CHEMBL4538570)
Affinity DataIC50:  0.0260nMAssay Description:Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50532607(CHEMBL4538570)
Affinity DataIC50:  0.0260nMAssay Description:Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143802(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143797(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143786(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50070888(CHEMBL298725 | Sodium; (Z)-2-benzo[1,2,5]thiadiazo...)
Affinity DataIC50:  0.0320nMAssay Description:In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50369954(CHEMBL1627023)
Affinity DataIC50:  0.0340nMAssay Description:Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104995(CHEMBL369489 | sodium salt of N-{6-[2-(5-Bromo-pyr...)
Affinity DataIC50:  0.0390nMAssay Description:In vitro inhibition of [125I]-ET-1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105033(CHEMBL112531 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50:  0.0390nMAssay Description:Ability to inhibit specific binding of [125I]- -ET-1 to rat A 10 cells which express endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143783(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061096((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(butane-1...)
Affinity DataIC50:  0.0400nMAssay Description:Ability to displace [125I]-ET-1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143778(2-{[3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-t...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098777(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50146613(5-{5-[(Z)-3-Benzo[1,3]dioxol-5-yl-3-carboxy-2-(4-m...)
Affinity DataIC50:  0.0500nMAssay Description:Ability to displace [125I]-ET-1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143789(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143773(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143801(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143785(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143788(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106408(4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2...)
Affinity DataIC50:  0.0700nMAssay Description:Binding affinity against endothelin A receptor in MMQ cells in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105027(CHEMBL176272 | sodium salt of 4-tert-Butyl-N-{6-[2...)
Affinity DataIC50:  0.0800nMAssay Description:In vitro inhibition of [125I]-ET-1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143787(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143780(3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143793(3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051007((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibitory activity against human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143794(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061086((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(3-chloro...)
Affinity DataIC50:  0.0940nMAssay Description:Ability to displace endothelin ([125I]-ET-1) from endothelin A receptor derived from MMQ cells of rodent.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061096((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(butane-1...)
Affinity DataIC50:  0.100nMAssay Description:Ability to displace endothelin ([125I]-ET-1) from endothelin A receptor derived from MMQ cells of rodent.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143774(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106403(4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2...)
Affinity DataIC50:  0.110nMAssay Description:Binding affinity against endothelin A receptor in MMQ cells in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143772(2-{[3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-t...)
Affinity DataIC50:  0.110nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50146606((Z)-2-Benzo[1,3]dioxol-5-yl-4-(4-methoxy-phenyl)-4...)
Affinity DataIC50:  0.120nMAssay Description:Ability to displace [125I]-ET-1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106400(4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2...)
Affinity DataIC50:  0.120nMAssay Description:Binding affinity against endothelin A receptor in MMQ cells in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143790(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.140nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098772(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.150nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106402(4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2...)
Affinity DataIC50:  0.170nMAssay Description:Binding affinity against endothelin A receptor in MMQ cells in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112678((R)-2-Benzo[1,3]dioxol-5-yl-6-isopropoxy-4-(4-meth...)
Affinity DataIC50:  0.190nMAssay Description:Ability to displace [125I]-ET-1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112678((R)-2-Benzo[1,3]dioxol-5-yl-6-isopropoxy-4-(4-meth...)
Affinity DataIC50:  0.190nMAssay Description:Binding affinity for endothelin A receptor by inhibition of [125I]-ET-1 binding in rat aorta smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112678((R)-2-Benzo[1,3]dioxol-5-yl-6-isopropoxy-4-(4-meth...)
Affinity DataIC50:  0.190nMAssay Description:Displacement of [125I]ET-1 from ET-A receptor in RASMC incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112738(2-Benzo[1,3]dioxol-5-yl-6-isopropoxy-4-(4-methoxy-...)
Affinity DataIC50:  0.210nMAssay Description:Binding affinity for endothelin A receptor by inhibition of [125I]-ET-1 binding in rat aorta smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143781(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-5-met...)
Affinity DataIC50:  0.210nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061099((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50:  0.210nMAssay Description:Ability to displace endothelin ([125I]-ET-1) from endothelin A receptor derived from MMQ cells of rodent.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50050975((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-[(butyl-propy...)
Affinity DataIC50:  0.220nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143777(CHEMBL61425 | TAK-044 | {(2S,5S,8S,11R,14R,17S)-14...)
Affinity DataIC50:  0.240nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50104987(CHEMBL367445 | sodium salt of 4-tert-Butyl-N-{6-[2...)
Affinity DataIC50:  0.25nMAssay Description:In vitro inhibition of [125I]-ET-1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112662(2-Benzo[1,3]dioxol-5-yl-4-butylsulfanyl-6-isopropo...)
Affinity DataIC50:  0.270nMAssay Description:Binding affinity for endothelin A receptor by inhibition of [125I]-ET-1 binding in rat aorta smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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