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Found 30 Enz. Inhib. hit(s) with all data for entry = 9174
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446832((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(2-oxo-1,2- d...)
Affinity DataIC50:  4.35nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446712((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(1R)-1-(4- fl...)
Affinity DataIC50:  5.04nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446712((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(1R)-1-(4- fl...)
Affinity DataIC50:  5.22nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446818((1R,2R,3R,5R,6R)-2-amino-3-[(5-chloropyridin-2- yl...)
Affinity DataIC50:  12.4nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446701(US10689327, Compound (II)-2)
Affinity DataIC50:  14.8nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446836((1S,2R,3R,5R,6S)-2-amino-3-[(3,4- difluorophenyl)m...)
Affinity DataIC50:  15.2nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446784((1R,2R,3R,5R,6R)-2-amino-3-[(6-chloropyridin-2- yl...)
Affinity DataIC50:  18.6nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446701(US10689327, Compound (II)-2)
Affinity DataIC50:  18.8nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446718((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-{[4- (triflour...)
Affinity DataIC50:  23.7nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446828((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(4- methylphe...)
Affinity DataIC50:  24.6nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446739((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(3- fluorophe...)
Affinity DataIC50:  27.8nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446818((1R,2R,3R,5R,6R)-2-amino-3-[(5-chloropyridin-2- yl...)
Affinity DataIC50:  28.4nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446836((1S,2R,3R,5R,6S)-2-amino-3-[(3,4- difluorophenyl)m...)
Affinity DataIC50:  30.1nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446784((1R,2R,3R,5R,6R)-2-amino-3-[(6-chloropyridin-2- yl...)
Affinity DataIC50:  32.3nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446857(US10689327, Compound (II)-15)
Affinity DataIC50:  32.7nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446699(US10689327, Compound (II)-1)
Affinity DataIC50:  36.1nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446699(US10689327, Compound (II)-1)
Affinity DataIC50:  36.4nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446832((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(2-oxo-1,2- d...)
Affinity DataIC50:  37.3nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446817((1R,2R,3R,5R,6R)-2-amino-3-[(6-chloropyridin-3- yl...)
Affinity DataIC50:  49.7nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446817((1R,2R,3R,5R,6R)-2-amino-3-[(6-chloropyridin-3- yl...)
Affinity DataIC50:  50.6nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446828((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(4- methylphe...)
Affinity DataIC50:  54.4nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446857(US10689327, Compound (II)-15)
Affinity DataIC50:  60.5nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM50151462((1R,2R,3R,5R,6R)-2-Amino-3-cyclopentyloxy-6-fluoro...)
Affinity DataIC50:  62.2nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446702(US10689327, Compound (II)-3)
Affinity DataIC50:  75.1nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446739((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(3- fluorophe...)
Affinity DataIC50:  75.5nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM50151462((1R,2R,3R,5R,6R)-2-Amino-3-cyclopentyloxy-6-fluoro...)
Affinity DataIC50:  97.6nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446756((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-(3- methylbuto...)
Affinity DataIC50:  98.8nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446756((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-(3- methylbuto...)
Affinity DataIC50:  173nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446718((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-{[4- (triflour...)
Affinity DataIC50:  279nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Taisho Pharmaceutical

US Patent
LigandPNGBDBM446702(US10689327, Compound (II)-3)
Affinity DataIC50:  321nMAssay Description:CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent