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Patent code US11034694

Compile Data Set for Download or QSAR

Found 837 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500986
PNG
(4-(7- (difluoromethv l)-8-fluoroimidazo [1,2-a]pyr...)
Show SMILES CC1(C)CNCCN1Cc1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3c(F)c(ccn23)C(F)F)nc1
Show InChI InChI=1S/C28H28F3N7O/c1-28(2)15-32-8-10-37(28)14-16-3-6-22(33-11-16)36-20-5-4-17(19-12-35-27(39)23(19)20)21-13-34-26-24(29)18(25(30)31)7-9-38(21)26/h3-7,9,11,13,25,32H,8,10,12,14-15H2,1-2H3,(H,33,36)(H,35,39)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500993
PNG
(US11021481, Compound I-662 | rel-(R)-4-(7- fluoroi...)
Show SMILES OC1(CC1)[C@@H]1CN(CCO1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1
Show InChI InChI=1S/C27H25FN6O3/c28-16-5-8-34-21(14-30-24(34)11-16)18-2-3-20(25-19(18)13-31-26(25)35)32-23-4-1-17(12-29-23)33-9-10-37-22(15-33)27(36)6-7-27/h1-5,8,11-12,14,22,36H,6-7,9-10,13,15H2,(H,29,32)(H,31,35)/t22-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500373
PNG
(7-[[5-(4- methylpiperazin- 1-yl)-2- pyridyl]amino]...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2ccnc3[nH]ccc23)nc1
Show InChI InChI=1S/C25H25N7O/c1-31-10-12-32(13-11-31)16-2-5-22(28-14-16)30-21-4-3-17(20-15-29-25(33)23(20)21)18-6-8-26-24-19(18)7-9-27-24/h2-9,14H,10-13,15H2,1H3,(H,26,27)(H,28,30)(H,29,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500379
PNG
(7-[[5-(4-methylpiperazin- 1-yl)-2- pyridyl]amino]-...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2c[nH]c3cc(C)ncc23)nc1
Show InChI InChI=1S/C26H27N7O/c1-16-11-23-20(14-27-16)19(13-28-23)18-4-5-22(25-21(18)15-30-26(25)34)31-24-6-3-17(12-29-24)33-9-7-32(2)8-10-33/h3-6,11-14,28H,7-10,15H2,1-2H3,(H,29,31)(H,30,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500387
PNG
(7-[[5-(4-methylpiperazin- 1-yl)-2- pyridyl]amino]-...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3[nH]ccc3c2)nc1
Show InChI InChI=1S/C25H25N7O/c1-31-8-10-32(11-9-31)18-2-5-22(27-14-18)30-21-4-3-19(20-15-29-25(33)23(20)21)17-12-16-6-7-26-24(16)28-13-17/h2-7,12-14H,8-11,15H2,1H3,(H,26,28)(H,27,30)(H,29,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501009
PNG
(7-((6- ((3aS, 6aS)- hexahydropyrr olo[3,4- b]pyrro...)
Show SMILES COc1cc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)nc(c1)N1CC[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C27H28N8O2/c1-34-7-5-18-17(3-6-29-26(18)34)25-19-12-31-27(36)24(19)20(13-30-25)32-22-9-16(37-2)10-23(33-22)35-8-4-15-11-28-14-21(15)35/h3,5-7,9-10,13,15,21,28H,4,8,11-12,14H2,1-2H3,(H,31,36)(H,32,33)/t15-,21+/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501019
PNG
((R)-7-((6-(4- amino-2- oxopyrrolidin- 1-yl)pyridin...)
Show SMILES Cn1ccc2c(ccnc12)-c1ncc(Nc2cccc(n2)N2C[C@H](N)CC2=O)c2C(=O)NCc12
Show InChI InChI=1S/C24H22N8O2/c1-31-8-6-15-14(5-7-26-23(15)31)22-16-10-28-24(34)21(16)17(11-27-22)29-18-3-2-4-19(30-18)32-12-13(25)9-20(32)33/h2-8,11,13H,9-10,12,25H2,1H3,(H,28,34)(H,29,30)/t13-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501029
PNG
(7-((6- ((dimethylamino)- methyl)-5- ((3S.4S]-4- fl...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1N1CC[C@H](F)[C@@H](O)C1
Show InChI InChI=1S/C28H29F2N7O2/c1-35(2)14-21-22(36-9-8-19(30)24(38)15-36)5-6-25(34-21)33-20-4-3-17(18-12-32-28(39)27(18)20)23-13-31-26-11-16(29)7-10-37(23)26/h3-7,10-11,13,19,24,38H,8-9,12,14-15H2,1-2H3,(H,32,39)(H,33,34)/t19-,24-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501043
PNG
((S)-7-((5-(3-(2- (dimethylami- no)propan-2- yl)-3-...)
Show SMILES CN(C)C(C)(C)[C@]1(O)CCCN(C1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1
Show InChI InChI=1S/C30H34FN7O2/c1-29(2,36(3)4)30(40)11-5-12-37(18-30)20-6-9-25(32-15-20)35-23-8-7-21(22-16-34-28(39)27(22)23)24-17-33-26-14-19(31)10-13-38(24)26/h6-10,13-15,17,40H,5,11-12,16,18H2,1-4H3,(H,32,35)(H,34,39)/t30-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500399
PNG
(4-imidazo[1,2- a]pyridin-3-yl- 7-[[5-[4- (methylam...)
Show SMILES CNC1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3ccccn23)nc1
Show InChI InChI=1S/C26H27N7O/c1-27-17-9-12-32(13-10-17)18-5-8-23(28-14-18)31-21-7-6-19(20-15-30-26(34)25(20)21)22-16-29-24-4-2-3-11-33(22)24/h2-8,11,14,16-17,27H,9-10,12-13,15H2,1H3,(H,28,31)(H,30,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500403
PNG
(7-[[5-[4- (methylamino)- 1-piperidyl]- 2-pyridyl]a...)
Show SMILES CNC1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)nc1
Show InChI InChI=1S/C27H29N7O/c1-28-17-8-13-34(14-9-17)18-3-6-24(30-15-18)32-23-5-4-19(22-16-31-27(35)25(22)23)20-7-11-29-26-21(20)10-12-33(26)2/h3-7,10-12,15,17,28H,8-9,13-14,16H2,1-2H3,(H,30,32)(H,31,35)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500431
PNG
(7-[(5-piperazin-1-yl- 2-pyridyl)amino]-4- pyrazolo...)
Show SMILES O=C1NCc2c1c(Nc1ccc(cn1)N1CCNCC1)ccc2-c1cnn2ccccc12
Show InChI InChI=1S/C24H23N7O/c32-24-23-19(14-27-24)17(18-15-28-31-10-2-1-3-21(18)31)5-6-20(23)29-22-7-4-16(13-26-22)30-11-8-25-9-12-30/h1-7,10,13,15,25H,8-9,11-12,14H2,(H,26,29)(H,27,32)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501064
PNG
(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-(6-(((...)
Show SMILES F[C@H]1CCN(Cc2nc(Nc3ccc(c4CNC(=O)c34)-c3cnc4cc(F)ccn34)ccc2[C@@H]2CCOC2)C1
Show InChI InChI=1S/C29H28F2N6O2/c30-18-6-9-37-25(13-32-27(37)11-18)21-1-3-23(28-22(21)12-33-29(28)38)34-26-4-2-20(17-7-10-39-16-17)24(35-26)15-36-8-5-19(31)14-36/h1-4,6,9,11,13,17,19H,5,7-8,10,12,14-16H2,(H,33,38)(H,34,35)/t17-,19+/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501076
PNG
((R)-7-((6-(((2,2- difluoroethyl))- methyl)amino) m...)
Show SMILES CN(CC(F)F)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1[C@H]1CCOC1
Show InChI InChI=1S/C28H27F3N6O2/c1-36(14-24(30)31)13-22-18(16-7-9-39-15-16)3-5-25(35-22)34-21-4-2-19(20-11-33-28(38)27(20)21)23-12-32-26-10-17(29)6-8-37(23)26/h2-6,8,10,12,16,24H,7,9,11,13-15H2,1H3,(H,33,38)(H,34,35)/t16-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501083
PNG
((R)-7-((6- (azetidin-1- ylmethyl)-5- (tetrahydrofu...)
Show SMILES Fc1ccn2c(cnc2c1)-c1ccc(Nc2ccc([C@H]3CCOC3)c(CN3CCC3)n2)c2C(=O)NCc12
Show InChI InChI=1S/C28H27FN6O2/c29-18-6-10-35-24(14-30-26(35)12-18)20-2-4-22(27-21(20)13-31-28(27)36)32-25-5-3-19(17-7-11-37-16-17)23(33-25)15-34-8-1-9-34/h2-6,10,12,14,17H,1,7-9,11,13,15-16H2,(H,31,36)(H,32,33)/t17-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500439
PNG
(4-0,3-dimethylpyrrolo [2,3-b]pyridin-4- yl)-7-[(5-...)
Show SMILES Cc1cn(C)c2nccc(-c3ccc(Nc4ccc(cn4)N4CCNCC4)c4C(=O)NCc34)c12
Show InChI InChI=1S/C26H27N7O/c1-16-15-32(2)25-23(16)19(7-8-28-25)18-4-5-21(24-20(18)14-30-26(24)34)31-22-6-3-17(13-29-22)33-11-9-27-10-12-33/h3-8,13,15,27H,9-12,14H2,1-2H3,(H,29,31)(H,30,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500465
PNG
(4-(7-methylimidazo [1,2-a]pyridin- 3-yl)-7-[(5- pi...)
Show SMILES Cc1ccn2c(cnc2c1)-c1ncc(Nc2ccc(cn2)N2CCNCC2)c2C(=O)NCc12
Show InChI InChI=1S/C24H24N8O/c1-15-4-7-32-19(14-27-21(32)10-15)23-17-12-29-24(33)22(17)18(13-28-23)30-20-3-2-16(11-26-20)31-8-5-25-6-9-31/h2-4,7,10-11,13-14,25H,5-6,8-9,12H2,1H3,(H,26,30)(H,29,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501096
PNG
(7-((6- ((dimethylamino)- methyl)-5- morpholinopy- ...)
Show SMILES CN(C)Cc1nc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)ccc1N1CCOCC1
Show InChI InChI=1S/C27H30N8O2/c1-33(2)16-21-22(35-10-12-37-13-11-35)4-5-23(32-21)31-20-15-29-25(19-14-30-27(36)24(19)20)17-6-8-28-26-18(17)7-9-34(26)3/h4-9,15H,10-14,16H2,1-3H3,(H,30,36)(H,31,32)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501098
PNG
((S)-7-((6- ((dimethylamino)- methyl)-5-(2-(2- hydr...)
Show SMILES CN(C)Cc1nc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)ccc1N1CCO[C@H](C1)C(C)(C)O
Show InChI InChI=1S/C30H36N8O3/c1-30(2,40)24-17-38(12-13-41-24)23-6-7-25(35-22(23)16-36(3)4)34-21-15-32-27(20-14-33-29(39)26(20)21)18-8-10-31-28-19(18)9-11-37(28)5/h6-11,15,24,40H,12-14,16-17H2,1-5H3,(H,33,39)(H,34,35)/t24-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501100
PNG
((S)-4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((...)
Show SMILES Fc1ccn2c(cnc2c1)-c1ccc(Nc2ccc([C@H]3CCOC3)c(n2)N2CCNCC2)c2C(=O)NCc12
Show InChI InChI=1S/C28H28FN7O2/c29-18-5-9-36-23(15-31-25(36)13-18)20-1-3-22(26-21(20)14-32-28(26)37)33-24-4-2-19(17-6-12-38-16-17)27(34-24)35-10-7-30-8-11-35/h1-5,9,13,15,17,30H,6-8,10-12,14,16H2,(H,32,37)(H,33,34)/t17-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501105
PNG
(7-((6- ((dimethylamino)- methyl)-5-(4- hydroxypipe...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1N1CCC(O)CC1
Show InChI InChI=1S/C28H30FN7O2/c1-34(2)16-22-23(35-10-8-18(37)9-11-35)5-6-25(33-22)32-21-4-3-19(20-14-31-28(38)27(20)21)24-15-30-26-13-17(29)7-12-36(24)26/h3-7,12-13,15,18,37H,8-11,14,16H2,1-2H3,(H,31,38)(H,32,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501122
PNG
(7-((6- ((dimethylamino)- methyl)-5- ((lR,3R)-3- me...)
Show SMILES CO[C@H]1CCC(C1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1CN(C)C
Show InChI InChI=1S/C29H31FN6O2/c1-35(2)16-24-20(17-4-5-19(12-17)38-3)7-9-26(34-24)33-23-8-6-21(22-14-32-29(37)28(22)23)25-15-31-27-13-18(30)10-11-36(25)27/h6-11,13,15,17,19H,4-5,12,14,16H2,1-3H3,(H,32,37)(H,33,34)/t17?,19-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM502285
PNG
(US11028085, Compound I-138)
Show SMILES OC1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1
Show InChI InChI=1S/C25H23FN6O2/c26-15-5-10-32-21(14-28-23(32)11-15)18-2-3-20(24-19(18)13-29-25(24)34)30-22-4-1-16(12-27-22)31-8-6-17(33)7-9-31/h1-5,10-12,14,17,33H,6-9,13H2,(H,27,30)(H,29,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM502291
PNG
(US11028085, Compound I-144)
Show SMILES Cn1ccc2c(ncnc12)-c1ccc(Nc2ccc(cn2)N2CCC(O)CC2)c2C(=O)NCc12
Show InChI InChI=1S/C25H25N7O2/c1-31-9-8-18-23(28-14-29-24(18)31)17-3-4-20(22-19(17)13-27-25(22)34)30-21-5-2-15(12-26-21)32-10-6-16(33)7-11-32/h2-5,8-9,12,14,16,33H,6-7,10-11,13H2,1H3,(H,26,30)(H,27,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500495
PNG
(7-[[5-(4-hydroxy-1- piperidyl)-2-pyridyl] amino]-4...)
Show SMILES Cc1ccn2c(cnc2c1)-c1ncc(Nc2ccc(cn2)N2CCC(O)CC2)c2C(=O)NCc12
Show InChI InChI=1S/C25H25N7O2/c1-15-4-9-32-20(14-27-22(32)10-15)24-18-12-29-25(34)23(18)19(13-28-24)30-21-3-2-16(11-26-21)31-7-5-17(33)6-8-31/h2-4,9-11,13-14,17,33H,5-8,12H2,1H3,(H,26,30)(H,29,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500513
PNG
(7-[[5-[(3R)-3- hydroxy-1- piperipyl]-2- pyridyl]am...)
Show SMILES Cc1ccn2c(cnc2c1)-c1ccc(Nc2ccc(cn2)N2CCC[C@@H](O)C2)c2C(=O)NCc12
Show InChI InChI=1S/C26H26N6O2/c1-16-8-10-32-22(14-28-24(32)11-16)19-5-6-21(25-20(19)13-29-26(25)34)30-23-7-4-17(12-27-23)31-9-2-3-18(33)15-31/h4-8,10-12,14,18,33H,2-3,9,13,15H2,1H3,(H,27,30)(H,29,34)/t18-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM502935
PNG
(US11028085, Compound I-801)
Show SMILES CN1CCN(CC1)c1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1[C@H]1CCOC1
Show InChI InChI=1S/C29H30FN7O2/c1-35-9-11-36(12-10-35)28-20(18-7-13-39-17-18)3-5-25(34-28)33-23-4-2-21(22-15-32-29(38)27(22)23)24-16-31-26-14-19(30)6-8-37(24)26/h2-6,8,14,16,18H,7,9-13,15,17H2,1H3,(H,32,38)(H,33,34)/t18-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501131
PNG
((R)-7-((6- ((dimethylamino)- methyl)-5-(3- hydroxy...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1[C@@]1(O)CCOC1
Show InChI InChI=1S/C27H27FN6O3/c1-33(2)14-21-19(27(36)8-10-37-15-27)4-6-23(32-21)31-20-5-3-17(18-12-30-26(35)25(18)20)22-13-29-24-11-16(28)7-9-34(22)24/h3-7,9,11,13,36H,8,10,12,14-15H2,1-2H3,(H,30,35)(H,31,32)/t27-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501138
PNG
(7-((6-(((R)-3- hydroxypyrroli- din-1- yl)methyl)-5...)
Show SMILES Cn1ccc2c(ccnc12)-c1ncc(Nc2ccc([C@H]3CCOC3)c(CN3CC[C@@H](O)C3)n2)c2C(=O)NCc12
Show InChI InChI=1S/C29H31N7O3/c1-35-9-6-21-20(4-8-30-28(21)35)27-22-12-32-29(38)26(22)23(13-31-27)33-25-3-2-19(17-7-11-39-16-17)24(34-25)15-36-10-5-18(37)14-36/h2-4,6,8-9,13,17-18,37H,5,7,10-12,14-16H2,1H3,(H,32,38)(H,33,34)/t17-,18+/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501139
PNG
(7-((6-(((S)-3- hydroxypyrroli- din-1- yl)methyl)-5...)
Show SMILES Cn1ccc2c(ccnc12)-c1ncc(Nc2ccc([C@@H]3CCOC3)c(CN3CC[C@H](O)C3)n2)c2C(=O)NCc12
Show InChI InChI=1S/C29H31N7O3/c1-35-9-6-21-20(4-8-30-28(21)35)27-22-12-32-29(38)26(22)23(13-31-27)33-25-3-2-19(17-7-11-39-16-17)24(34-25)15-36-10-5-18(37)14-36/h2-4,6,8-9,13,17-18,37H,5,7,10-12,14-16H2,1H3,(H,32,38)(H,33,34)/t17-,18+/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501147
PNG
((R)-7-((6- ((dimethylamino)- methyl)-5- (6-hydroxy...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1N1CCOC[C@H](O)C1
Show InChI InChI=1S/C28H30FN7O3/c1-34(2)15-22-23(35-9-10-39-16-18(37)14-35)5-6-25(33-22)32-21-4-3-19(20-12-31-28(38)27(20)21)24-13-30-26-11-17(29)7-8-36(24)26/h3-8,11,13,18,37H,9-10,12,14-16H2,1-2H3,(H,31,38)(H,32,33)/t18-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501148
PNG
((S)-7-((6- ((dimethylamino)- methyl)-5- (6-hydroxy...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1N1CCOC[C@@H](O)C1
Show InChI InChI=1S/C28H30FN7O3/c1-34(2)15-22-23(35-9-10-39-16-18(37)14-35)5-6-25(33-22)32-21-4-3-19(20-12-31-28(38)27(20)21)24-13-30-26-11-17(29)7-8-36(24)26/h3-8,11,13,18,37H,9-10,12,14-16H2,1-2H3,(H,31,38)(H,32,33)/t18-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501151
PNG
(7-((6- ((dimethylamino)- methyl)-5-(1- methoxycycl...)
Show SMILES COC1(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1CN(C)C
Show InChI InChI=1S/C27H27FN6O2/c1-33(2)15-21-19(27(36-3)9-10-27)5-7-23(32-21)31-20-6-4-17(18-13-30-26(35)25(18)20)22-14-29-24-12-16(28)8-11-34(22)24/h4-8,11-12,14H,9-10,13,15H2,1-3H3,(H,30,35)(H,31,32)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501152
PNG
(4-(2- ((dimethylami no)methyl)-6- ((7-(7- fluoroim...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1C1(CCOCC1)C#N
Show InChI InChI=1S/C29H28FN7O2/c1-36(2)16-23-21(29(17-31)8-11-39-12-9-29)4-6-25(35-23)34-22-5-3-19(20-14-33-28(38)27(20)22)24-15-32-26-13-18(30)7-10-37(24)26/h3-7,10,13,15H,8-9,11-12,14,16H2,1-2H3,(H,33,38)(H,34,35)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501156
PNG
(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((6- (...)
Show SMILES OC[C@@H]1CCCN1Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1[C@@H]1CCOC1
Show InChI InChI=1S/C30H31FN6O3/c31-19-7-10-37-26(14-32-28(37)12-19)22-3-5-24(29-23(22)13-33-30(29)39)34-27-6-4-21(18-8-11-40-17-18)25(35-27)15-36-9-1-2-20(36)16-38/h3-7,10,12,14,18,20,38H,1-2,8-9,11,13,15-17H2,(H,33,39)(H,34,35)/t18-,20+/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500519
PNG
(7-[[5-[(3R)-3- hydroxy-1- piperidyl]-2- pyridyl]am...)
Show SMILES Cn1ccc2c(ccnc12)-c1ncc(Nc2ccc(cn2)N2CCC[C@@H](O)C2)c2C(=O)NCc12
Show InChI InChI=1S/C25H25N7O2/c1-31-10-7-18-17(6-8-26-24(18)31)23-19-12-29-25(34)22(19)20(13-28-23)30-21-5-4-15(11-27-21)32-9-2-3-16(33)14-32/h4-8,10-11,13,16,33H,2-3,9,12,14H2,1H3,(H,27,30)(H,29,34)/t16-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500520
PNG
(7-[[5-[(3S)-3- hydroxy-1- piperidyl]-2- pyridyl]am...)
Show SMILES Cn1ccc2c(ccnc12)-c1ncc(Nc2ccc(cn2)N2CCC[C@H](O)C2)c2C(=O)NCc12
Show InChI InChI=1S/C25H25N7O2/c1-31-10-7-18-17(6-8-26-24(18)31)23-19-12-29-25(34)22(19)20(13-28-23)30-21-5-4-15(11-27-21)32-9-2-3-16(33)14-32/h4-8,10-11,13,16,33H,2-3,9,12,14H2,1H3,(H,27,30)(H,29,34)/t16-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500522
PNG
(4-(7-cyclopropyl- imidazo[1,2- a]pyridin-3- yl)-7-...)
Show SMILES OC1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(ccn23)C2CC2)nc1
Show InChI InChI=1S/C28H28N6O2/c35-20-8-10-33(11-9-20)19-3-6-25(29-14-19)32-23-5-4-21(22-15-31-28(36)27(22)23)24-16-30-26-13-18(17-1-2-17)7-12-34(24)26/h3-7,12-14,16-17,20,35H,1-2,8-11,15H2,(H,29,32)(H,31,36)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500529
PNG
(8-fluoro-3-[7- [[5-(4-hydroxy-1- piperidyl)-2- pyr...)
Show SMILES OC1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3c(F)c(ccn23)C#N)nc1
Show InChI InChI=1S/C26H22FN7O2/c27-24-15(11-28)5-10-34-21(14-30-25(24)34)18-2-3-20(23-19(18)13-31-26(23)36)32-22-4-1-16(12-29-22)33-8-6-17(35)7-9-33/h1-5,10,12,14,17,35H,6-9,13H2,(H,29,32)(H,31,36)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500535
PNG
(4-[7-(difluorometh- yl)imidazo[1,2- a]pyridin-3- y...)
Show SMILES OC1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(ccn23)C(F)F)nc1
Show InChI InChI=1S/C26H24F2N6O2/c27-25(28)15-5-10-34-21(14-30-23(34)11-15)18-2-3-20(24-19(18)13-31-26(24)36)32-22-4-1-16(12-29-22)33-8-6-17(35)7-9-33/h1-5,10-12,14,17,25,35H,6-9,13H2,(H,29,32)(H,31,36)
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n/an/a<100n/an/an/an/an/an/a



Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500541
PNG
(4-[1-(difluorometh- yl)pyrrolo[2,3- b]pyridin-4- y...)
Show SMILES OC1CCN(CC1)c1ccc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3n(ccc23)C(F)F)nc1
Show InChI InChI=1S/C25H23F2N7O2/c26-25(27)34-10-6-17-16(3-7-28-23(17)34)22-18-12-31-24(36)21(18)19(13-30-22)32-20-2-1-14(11-29-20)33-8-4-15(35)5-9-33/h1-3,6-7,10-11,13,15,25,35H,4-5,8-9,12H2,(H,29,32)(H,31,36)
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n/an/a<100n/an/an/an/an/an/a



Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500543
PNG
(4-(7-fluoroimidazo [1,2-a]pyridin- 3-yl)-7-[[5- 1(...)
Show SMILES CC(C)(O)[C@@H]1CCCN(C1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1
Show InChI InChI=1S/C28H29FN6O2/c1-28(2,37)17-4-3-10-34(16-17)19-5-8-24(30-13-19)33-22-7-6-20(21-14-32-27(36)26(21)22)23-15-31-25-12-18(29)9-11-35(23)25/h5-9,11-13,15,17,37H,3-4,10,14,16H2,1-2H3,(H,30,33)(H,32,36)/t17-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500554
PNG
(4-(7-fluoroimidazo [1,2-a]pyridin- 3-yl)-7-[[5- [(...)
Show SMILES CC(C)(O)[C@H]1CCCN(C1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1
Show InChI InChI=1S/C28H29FN6O2/c1-28(2,37)17-4-3-10-34(16-17)19-5-8-24(30-13-19)33-22-7-6-20(21-14-32-27(36)26(21)22)23-15-31-25-12-18(29)9-11-35(23)25/h5-9,11-13,15,17,37H,3-4,10,14,16H2,1-2H3,(H,30,33)(H,32,36)/t17-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501174
PNG
(7-[[6- [(dimethylamino)- methyl]-5- tetrahydrofura...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnn3cc(C)cnc23)ccc1C1CCOC1
Show InChI InChI=1S/C27H29N7O2/c1-16-10-28-26-21(12-30-34(26)13-16)19-4-6-22(25-20(19)11-29-27(25)35)31-24-7-5-18(17-8-9-36-15-17)23(32-24)14-33(2)3/h4-7,10,12-13,17H,8-9,11,14-15H2,1-3H3,(H,29,35)(H,31,32)
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n/an/a<100n/an/an/an/an/an/a



Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500564
PNG
(7-[[5-[(3R)-3- (1-hydroxy-1- methyl-ethyl)- 1-pipe...)
Show SMILES Cn1ccc2c(cccc12)-c1ncc(Nc2ccc(cn2)N2CCC[C@H](C2)C(C)(C)O)c2C(=O)NCc12
Show InChI InChI=1S/C29H32N6O2/c1-29(2,37)18-6-5-12-35(17-18)19-9-10-25(30-14-19)33-23-16-31-27(22-15-32-28(36)26(22)23)21-7-4-8-24-20(21)11-13-34(24)3/h4,7-11,13-14,16,18,37H,5-6,12,15,17H2,1-3H3,(H,30,33)(H,32,36)/t18-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500610
PNG
(2-(4-(7-((5-(4- methylpiperazin- 1-yl)pyridin- 2-y...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2ccnc3n(CC(N)=O)ccc23)nc1
Show InChI InChI=1S/C27H28N8O2/c1-33-10-12-34(13-11-33)17-2-5-24(30-14-17)32-22-4-3-18(21-15-31-27(37)25(21)22)19-6-8-29-26-20(19)7-9-35(26)16-23(28)36/h2-9,14H,10-13,15-16H2,1H3,(H2,28,36)(H,30,32)(H,31,37)
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n/an/a<100n/an/an/an/an/an/a



Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500637
PNG
(7-((5-(6- hydroxy-2- azaspiro[3,3] heptan-2- yl)py...)
Show SMILES Cn1ccc2c(ccnc12)-c1ccc(Nc2ccc(cn2)N2CC3(CC(O)C3)C2)c2C(=O)NCc12
Show InChI InChI=1S/C27H26N6O2/c1-32-9-7-20-19(6-8-28-25(20)32)18-3-4-22(24-21(18)13-30-26(24)35)31-23-5-2-16(12-29-23)33-14-27(15-33)10-17(34)11-27/h2-9,12,17,34H,10-11,13-15H2,1H3,(H,29,31)(H,30,35)
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n/an/a<100n/an/an/an/an/an/a



Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500654
PNG
((S)-4- (imidazo[1,2- a]pyrazin-3- yl)-7-((5-(3- me...)
Show SMILES C[C@H]1COCCN1c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cnccn23)nc1
Show InChI InChI=1S/C24H23N7O2/c1-15-14-33-9-8-30(15)16-2-5-21(26-10-16)29-19-4-3-17(18-11-28-24(32)23(18)19)20-12-27-22-13-25-6-7-31(20)22/h2-7,10,12-13,15H,8-9,11,14H2,1H3,(H,26,29)(H,28,32)/t15-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500668
PNG
((S)-7-((5-(4- hydroxyazepa n-1-yl)pyridin- 2-yl)am...)
Show SMILES O[C@H]1CCCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cnccn23)nc1
Show InChI InChI=1S/C25H25N7O2/c33-17-2-1-9-31(10-7-17)16-3-6-22(27-12-16)30-20-5-4-18(19-13-29-25(34)24(19)20)21-14-28-23-15-26-8-11-32(21)23/h3-6,8,11-12,14-15,17,33H,1-2,7,9-10,13H2,(H,27,30)(H,29,34)/t17-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500671
PNG
((S)-4- (imidazo[1,2- a]pyrazin-3- yl)-7-((5-(1- me...)
Show SMILES CN1CC(CC1=O)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cnccn23)nc1
Show InChI InChI=1S/C24H21N7O2/c1-30-13-15(8-22(30)32)14-2-5-20(26-9-14)29-18-4-3-16(17-10-28-24(33)23(17)18)19-11-27-21-12-25-6-7-31(19)21/h2-7,9,11-12,15H,8,10,13H2,1H3,(H,26,29)(H,28,33)
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n/an/a<100n/an/an/an/an/an/a



Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11034694 (2021)

More data for this
Ligand-Target Pair
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