TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 3nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 12nMAssay Description:Inhibition of human COX1-mediated conversion of arachidonic acid to prostaglandin-E2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 12nMAssay Description:Inhibition of COX1 assessed as inhibition of arachidonic acid conversion to prostaglandin-E2 releaseMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 12nMAssay Description:Inhibition of cyclooxygenase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 30nMAssay Description:Inhibition of human COX1 expressed in sf9 cellsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Inhibition of ovine COX1 for 17 mins pre-incubated before addition of [1-14C]arachidonic acidMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 10 mins prior to substrate addition measured after 2 mins by spectrophotom...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of ovine COX1 assessed as reduction in PGH2-derived PGF2alpha using arachidonic acid as substrate preincubated for 10 mins followed by sub...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of ovine COX-1 preincubated for 5 mins followed by arachidonic acid substrate addition by colorimetric enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 150nMAssay Description:In vitro inhibitory activity against human whole blood Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of ovine COX1 after 2 mins by EIAMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of ovine COX1 assessed as inhibition of PGF2alpha production from PGH2 preincubated for 5 mins before arachidonic acid addition measured a...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of purified ovine COX1 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver estera...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:In vitro inhibition of prostaglandin synthesis was tested in ratMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 610nMAssay Description:Inhibition of ovine COX-1 assessed as PGF2alpha formation using arachidonic acid as substrate pretreated with compound for 20 mins prior to substrate...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 6.24E+3nMAssay Description:Inhibition of ovine COX1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by enzyme i...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Vanderbilt Institute For Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 6.25E+3nMAssay Description:Inhibition of ovine COX1 peroxidase activity assessed as reduction of PGG2 to PGH2 by measuring oxidized TMPD level by colorimetric assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of COX1 in human platelet microsomes assessed as reduction in formation of oxidized TMPD using arachidonic acid as substrate preincubated ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Dallas Department of Veterans Affairs Medical Center
Curated by PDSP Ki Database
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human recombinant COX1 expressed in Sf9 cell microsomes assessed as reduction in conversion of arachidonic acid to PGE2 incubated for 5...More data for this Ligand-Target Pair