Compile Data Set for Download or QSAR
maximum 50k data
Found 36 Enz. Inhib. hit(s) with all data for entry = 50010345
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093722((6R,7R)-3-(4-Carboxymethyl-4H-[1,2,4]triazol-3-yls...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093718((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093741((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093716((6R,7R)-3-(1-Carboxymethyl-1H-tetrazol-5-ylsulfany...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093716((6R,7R)-3-(1-Carboxymethyl-1H-tetrazol-5-ylsulfany...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093736((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093731((6R,7R)-3-Chloromethyl-7-[2-(4-hydroxy-phenyl)-ace...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093722((6R,7R)-3-(4-Carboxymethyl-4H-[1,2,4]triazol-3-yls...)
Affinity DataIC50:  160nMAssay Description:The compound was evaluated for the inhibitory activity against alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093742((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  170nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093722((6R,7R)-3-(4-Carboxymethyl-4H-[1,2,4]triazol-3-yls...)
Affinity DataIC50:  230nMAssay Description:The compound was evaluated for the inhibitory activity against cathepsin GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093720((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093729((6R,7R)-7-Methoxy-3-(1-methyl-2,3-dihydro-1H-tetra...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093726((6R,7R)-7-Methoxy-7-[2-(4-methoxy-phenyl)-acetylam...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093730((6R,7R)-7-[2-(4-Dimethylamino-phenyl)-acetylamino]...)
Affinity DataIC50:  410nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093717((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093722((6R,7R)-3-(4-Carboxymethyl-4H-[1,2,4]triazol-3-yls...)
Affinity DataIC50:  430nMAssay Description:The compound was evaluated for the inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093722((6R,7R)-3-(4-Carboxymethyl-4H-[1,2,4]triazol-3-yls...)
Affinity DataIC50:  440nMAssay Description:The compound was evaluated for the inhibitory activity against trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093735((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  440nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093734((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093727((6R,7R)-7-Methoxy-7-(2-methoxy-benzoylamino)-3-(1-...)
Affinity DataIC50:  550nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093724((6R,7R)-7-Benzoylamino-7-methoxy-3-(1-methyl-2,3-d...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093738((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093725((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093743((6R,7R)-7-(2-Chloro-benzoylamino)-7-methoxy-3-(1-m...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093733((6R,7R)-7-Methoxy-7-(2-methoxycarbonyl-benzoylamin...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093723((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093739((6R,7R)-7-[2-(4-Bromo-phenyl)-acetylamino]-7-metho...)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093721((6R,7R)-7-Methoxy-7-(3-methoxy-benzoylamino)-3-(1-...)
Affinity DataIC50:  7.31E+3nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093737((6R,7R)-7-(2-Biphenyl-4-yl-acetylamino)-7-methoxy-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093722((6R,7R)-3-(4-Carboxymethyl-4H-[1,2,4]triazol-3-yls...)
Affinity DataIC50: >1.00E+4nMAssay Description:The compound was evaluated for the inhibitory activity against human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093722((6R,7R)-3-(4-Carboxymethyl-4H-[1,2,4]triazol-3-yls...)
Affinity DataIC50: >1.00E+4nMAssay Description:The compound was evaluated for the inhibitory activity against plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093732((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093744(2-(4-Hydroxy-phenyl)-N-[(6R,7R)-7-methoxy-3-(1-met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093719((6R,7R)-7-Methoxy-7-(4-methoxy-benzoylamino)-3-(1-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093740((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50093728((6R,7R)-7-[2-(4-Hydroxy-phenyl)-acetylamino]-7-met...)
Affinity DataIC50:  1.56E+4nMAssay Description:Inhibitory activity against human serine protease chymaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed