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Found 98 Enz. Inhib. hit(s) with all data for entry = 50039468
TargetD(1A) dopamine receptor(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM82247(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]LSD from human 5HT7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM21393(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [125I]2-iodomelatonin from human MT1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50366495((+)butaclamol | CHEMBL1255588)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]methyl-spiperone from human dopamine D2s receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Affinity DataKi:  0.770nMAssay Description:Displacement of [3H]imipramine from human 5HT transporterMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM28582(1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | CHE...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I](+/-)-DOI from human 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50005534(1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine ...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]BTCP from human DA transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50176062(3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]nisoxetine from human NE transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM82561(CAS_40796-97-2 | TROPANYL 3,5-DICHLOROBENZOATE | T...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]BRL43694 from human 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  14nMAssay Description:Displacement of [125I]CYP from human 5HT1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataKi:  17nMAssay Description:Inhibition of MAO-AMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM11022(2,3-dihydro-1H-indole-2,3-dione | CHEMBL326294 | I...)
Affinity DataKi:  33nMAssay Description:Inhibition of MAO-BMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  84nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  170nMAssay Description:Displacement of [3H]LSD from human 5HT5A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM25753(2-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl...)
Affinity DataKi:  170nMAssay Description:Displacement of [3H](-)-CGP12177 from human adrenergic beta1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50289137(6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole | ...)
Affinity DataKi:  880nMAssay Description:Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataKi:  5.60E+3nMAssay Description:Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350249(CHEMBL1812547)
Affinity DataKi:  3.24E+4nMAssay Description:Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350250(CHEMBL1812660)
Affinity DataKi:  4.00E+4nMAssay Description:Inhibition of IDOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
University Of Namur

Curated by ChEMBL
LigandPNGBDBM21974((2S)-2-amino-3-(1H-indol-3-yl)propanoic acid | CHE...)
Affinity DataKi:  1.15E+7nMAssay Description:Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50289137(6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole | ...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350293(CHEMBL1812539)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50289138(3-((E)-2-Pyridin-3-yl-vinyl)-1H-indole | CHEMBL441...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350298(CHEMBL1812546)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50289136(6-Fluoro-3-((E)-2-pyridin-4-yl-vinyl)-1H-indole | ...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350285(CHEMBL1812531)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350296(CHEMBL1812543)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350249(CHEMBL1812547)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350294(CHEMBL1812540)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50289140(5-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole | ...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350240(CHEMBL1812554)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350292(CHEMBL1812538)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350289(CHEMBL1812535)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350262(CHEMBL1812506)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350297(CHEMBL1812544)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350308(CHEMBL1812541)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350299(CHEMBL445966)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350254(CHEMBL1812498)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350267(CHEMBL1812512)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350282(CHEMBL1812528)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350275(CHEMBL1812520)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50289142(3-((E)-2-Pyridin-4-yl-vinyl)-1H-indole | CHEMBL166...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50289139(3-((E)-2-Pyridin-2-yl-vinyl)-1H-indole | CHEMBL171...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350268(CHEMBL1812513)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350270(CHEMBL1812515)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350287(CHEMBL1812533)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
University Of Namur

Curated by ChEMBL
LigandPNGBDBM50350263(CHEMBL1812507)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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