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Target
RNA-directed RNA polymerase
Ligand
BDBM50183480
Substrate
n/a
Meas. Tech.
ChEMBL_337076 (CHEMBL864354)
EC50
13600±n/a nM
Citation
Koch, U; Attenni, B; Malancona, S; Colarusso, S; Conte, I; Di Filippo, M; Harper, S; Pacini, B; Giomini, C; Thomas, S; Incitti, I; Tomei, L; De Francesco, R; Altamura, S; Matassa, VG; Narjes, F 2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis. J Med Chem 49:1693-705 (2006) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50183480
Synonyms:
2-[3-({[(2-chloro-6-methylbenzyl)amino]carbonyl}amino)-2-thienyl]-5,6-dihydroxypyrimidine-4-carboxylic acid | CHEMBL206793
Type:
Small organic molecule
Emp. Form.:
C18H15ClN4O5S
Mol. Mass.:
434.854
SMILES:
Cc1cccc(Cl)c1CNC(=O)Nc1ccsc1-c1nc(C(O)=O)c(O)c(=O)[nH]1