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Target
Acidic mammalian chitinase
Ligand
BDBM72759
Substrate
n/a
Meas. Tech.
ChEMBL_649681 (CHEMBL1219379)
IC50
700±n/a nM
Citation
Cole, DC; Olland, AM; Jacob, J; Brooks, J; Bursavich, MG; Czerwinski, R; DeClercq, C; Johnson, M; Joseph-McCarthy, D; Ellingboe, JW; Lin, L; Nowak, P; Presman, E; Strand, J; Tam, A; Williams, CM; Yao, S; Tsao, DH; Fitz, LJ Identification and characterization of acidic mammalian chitinase inhibitors. J Med Chem 53:6122-8 (2010) [PubMed] Article
More Info.:
Target
Name:
Acidic mammalian chitinase
Synonyms:
AMCase | Acidic mammalian chitinase (AMCase) | CHIA | CHIA_HUMAN | Lung-specific protein TSA1902
Type:
Protein
Mol. Mass.:
52266.66
Organism:
Homo sapiens (Human)
Description:
Q9BZP6
Residue:
476
Sequence:
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
Inhibitor
Name:
BDBM72759
Synonyms:
2-methyl-3-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-indole | 2-methyl-3-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-indole | 2-methyl-3-[[4-(2-pyridyl)piperazino]methyl]-1H-indole | 2-methyl-3-{[4-(2-pyridinyl)piperazino]methyl}-1H-indole | MLS000860449 | SMR000458533 | cid_2813100
Type:
Small organic molecule
Emp. Form.:
C19H22N4
Mol. Mass.:
306.4048
SMILES:
Cc1[nH]c2ccccc2c1CN1CCN(CC1)c1ccccn1