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TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataKi:  0.0640nMAssay Description:Binding affinity to HSP90 under reducing conditions in presence of TECPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataKi:  0.0690nMAssay Description:Binding affinity to HSP90 under non-reducing conditions in absence of TECPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50357454(CHEMBL1917878)
Affinity DataKd:  0.350nMAssay Description:Binding affinity to human Hsp90beta after overnight incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50482743(CHEMBL1215467)
Affinity DataKd:  0.540nMAssay Description:Binding affinity to human N-terminal ATPase domain of Hsp90 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50593502(CHEMBL1215539)
Affinity DataKd:  0.540nMAssay Description:Inhibition of HSP90 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  0.546nMAssay Description:Binding affinity to human HSP90AB1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50593503(CHEMBL5174695)
Affinity DataKd:  0.710nMAssay Description:Inhibition of HSP90 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50: 1nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as pS6 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50048364(CHEMBL3309997)
Affinity DataKi:  1nMAssay Description:Inhibition of Hsp90 (unknown origin) by FP displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50378702(SNX-2112 | CHEMBL560895)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to HSP90 under reducing conditions in presence of TECPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM20800(CHEMBL467399 | 6-chloro-9-[(4-methoxy-3,5-dimethyl...)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to Hsp90 nucleotide binding domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataKd:  1.70nMAssay Description:Binding affinity to Hsp90 nucleotide binding domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50097905(CHEMBL3589960)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human recombinant HSP90 by scintillation proximity competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM20800(CHEMBL467399 | 6-chloro-9-[(4-methoxy-3,5-dimethyl...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of recombinant His-tagged full length human HSP90 (9 to 236 residues) expressed in Escherichia coli BL21(DE3) cells after 18 hrs by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM20800(CHEMBL467399 | 6-chloro-9-[(4-methoxy-3,5-dimethyl...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to HSP90 by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50394065(CHEMBL2158626)
Affinity DataKi:  2nMAssay Description:Inhibition of fluorescently labeled VER51001 binding to full length human HSP90beta after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50: 2nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as Hsp70 induction after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50394056(CHEMBL2158577)
Affinity DataKi:  2nMAssay Description:Inhibition of fluorescently labeled VER51001 binding to full length human HSP90beta after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50394058(CHEMBL2158570)
Affinity DataKi:  2nMAssay Description:Inhibition of fluorescently labeled VER51001 binding to full length human HSP90beta after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50645078(CHEMBL5574581)
Affinity DataKd:  2nMAssay Description:Binding affinity to human N-terminal his tagged Hsp90beta (1 to 239 residues) expressed in Escherichia coli (DE3) strain assessed as dissociation con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50097903(CHEMBL3589958)
Affinity DataKi:  2.10nMAssay Description:Inhibition of human recombinant HSP90 by scintillation proximity competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataKd:  2.20nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50378702(SNX-2112 | CHEMBL560895)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to HSP90 under non-reducing conditions in absence of TECPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50492759(CHEMBL2413569)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50150160(Carbamic acid (4E,6Z,10E)-(8S,9S,12S,13R,14S,16R)-...)
Affinity DataIC50: 3nMAssay Description:Concentration of test compound required for inhibition of binding of rHsp90 in MCF-7 cell lysateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50394064(CHEMBL2158627)
Affinity DataKi:  3nMAssay Description:Inhibition of fluorescently labeled VER51001 binding to full length human HSP90beta after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50455692(CHEMBL3911424)
Affinity DataKd:  3nMAssay Description:Binding affinity to recombinant N-terminal Hsp90 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50003870(CHEMBL3235355)
Affinity DataKi:  3nMAssay Description:Displacement of FITC-geldanamycin from recombinant HSP90beta (unknown origin) after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50030868(17-amino-17-demethoxygeldanamycin | Carbamic acid ...)
Affinity DataKi:  3nMAssay Description:Binding affinity to HSP90 under reducing conditions in presence of TECPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50645077(CHEMBL5569309)
Affinity DataKd:  3nMAssay Description:Binding affinity to human N-terminal his tagged Hsp90beta (1 to 239 residues) expressed in Escherichia coli (DE3) strain assessed as dissociation con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50394059(CHEMBL2158569)
Affinity DataKi:  3nMAssay Description:Inhibition of fluorescently labeled VER51001 binding to full length human HSP90beta after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50008057(CHEBI:64153 | BMS-722782 | TANESPIMYCIN)
Affinity DataIC50: 3nMAssay Description:Inhibition of Hsp90 in human AU565 cells assessed as Her2 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50097907(CHEMBL3589962)
Affinity DataKi:  3.30nMAssay Description:Inhibition of human recombinant HSP90 by scintillation proximity competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50492753(CHEMBL2413570)
Affinity DataKd:  3.5nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50492754(CHEMBL2413568)
Affinity DataKd:  3.60nMAssay Description:Binding affinity to human Hsp90 by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50455734(CHEMBL3889463)
Affinity DataKd:  3.60nMAssay Description:Binding affinity to recombinant N-terminal Hsp90 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50455705(CHEMBL3907641)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to recombinant N-terminal Hsp90 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50455704(CHEMBL3920953)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to recombinant N-terminal Hsp90 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50008057(CHEBI:64153 | BMS-722782 | TANESPIMYCIN)
Affinity DataIC50: 4nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as Hsp70 induction after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50394066(CHEMBL2158625)
Affinity DataKi:  4nMAssay Description:Inhibition of fluorescently labeled VER51001 binding to full length human HSP90beta after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50379853(CHEMBL2011854)
Affinity DataIC50: 4nMAssay Description:Inhibition of HSP90-mediated Her2 degradation in human AU565 cells after 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50482743(CHEMBL1215467)
Affinity DataIC50: 4nMAssay Description:Inhibition of HSP90beta (unknown origin) incubated for 24 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50645077(CHEMBL5569309)
Affinity DataKd:  4nMAssay Description:Binding affinity to human N-terminal his tagged Hsp90beta (1 to 239 residues) expressed in Escherichia coli (DE3) strain assessed as dissociation con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50: 4nMAssay Description:Inhibition of FITC-GDA binding to human HSP90-beta incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50005781(CHEBI:65324 | ALVESPIMYCIN)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of Hsp90 in human MDA-MB-231 cells assessed as her2 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50455711(CHEMBL3901758)
Affinity DataKd:  4.60nMAssay Description:Binding affinity to recombinant N-terminal Hsp90 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50482760(CHEMBL1231550)
Affinity DataKd:  4.80nMAssay Description:Binding affinity to human N-terminal ATPase domain of Hsp90 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50379853(CHEMBL2011854)
Affinity DataIC50: 5nMAssay Description:Inhibition of HSP90 in human A375 cells assessed as induction of HSP70 synthesis after 24 hrs by TRITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50249943(11-O-(Hydrzinocarbonyl)-17-[2-(dimethylamino)ethyl...)
Affinity DataIC50: 5nMAssay Description:Binding affinity to human recombinant HSP90More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50048357(CHEMBL3309990)
Affinity DataKi:  5nMAssay Description:Inhibition of Hsp90 (unknown origin) by FP displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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