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Report error Found 764 of affinity data for UniProtKB/TrEMBL: P23946
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50520051BDBM50520051(CHEMBL4592765)
Affinity DataKi:  0.220nMAssay Description:Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100340BDBM100340(US8501749, 40)
Affinity DataIC50: 0.300nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100336BDBM100336(US8501749, 36)
Affinity DataIC50: 0.400nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50332961BDBM50332961((3S,4S)-3-Benzyl-4-(4-methylpiperazincarbonyl)phen...)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of human ChymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100335BDBM100335(US8501749, 35)
Affinity DataIC50: 0.700nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100338BDBM100338(US8501749, 38)
Affinity DataIC50: 0.700nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50101136BDBM50101136(1,3-Bis-benzo[1,3]dioxol-5-ylmethyl-[1,3]diazetidi...)
Affinity DataIC50: 0.850nMAssay Description:Compound was evaluated for its inhibitory activity against human Serine protease chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100324BDBM100324(US8501749, 24)
Affinity DataIC50: 0.900nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098853BDBM50098853(2-(2-{2-[5-Amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyr...)
Affinity DataKi:  1.12nMAssay Description:Inhibitory activity against canine skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068901BDBM50068901(3-[2,2-Difluoro-4-({(S)-1-[(S)-3-methyl-2-(3-pheny...)
Affinity DataKi:  1.30nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100341BDBM100341(US8501749, 41)
Affinity DataIC50: 1.30nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100330BDBM100330(US8501749, 30)
Affinity DataIC50: 1.40nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100339BDBM100339(US8501749, 39)
Affinity DataIC50: 1.40nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50520048BDBM50520048(CHEMBL4450993)
Affinity DataKi:  1.70nMAssay Description:Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50520049BDBM50520049(CHEMBL4560112)
Affinity DataKi:  1.80nMAssay Description:Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50101135BDBM50101135(1,3-Bis-(4-methoxy-benzyl)-[1,3]diazetidine-2,4-di...)
Affinity DataIC50: 2nMAssay Description:Compound was evaluated for its inhibitory activity against human Serine protease chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100320BDBM100320(US8501749, 20)
Affinity DataIC50: 2.10nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50520060BDBM50520060(CHEMBL4465306)
Affinity DataKi:  2.20nMAssay Description:Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells using NleTDY-pNA as substrate assessed as cleavage of pNA at pH 7.2 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100331BDBM100331(US8501749, 31)
Affinity DataIC50: 2.20nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50101137BDBM50101137(1,3-Bis-(3-methoxy-benzyl)-[1,3]diazetidine-2,4-di...)
Affinity DataIC50: 2.30nMAssay Description:Compound was evaluated for its inhibitory activity against human Serine protease chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50139758BDBM50139758(1-(naphthalen-1-yl)-2-(naphthalen-2-yl)-2-oxoethyl...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of chymase in human mast cells using Suc-Ala-Ala-Pro-Phe-(p-nitroanilide) as substrate for 15 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50208224BDBM50208224(2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carba...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100325BDBM100325(US8501749, 25)
Affinity DataIC50: 2.5nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100318BDBM100318(US8501749, 18)
Affinity DataIC50: 2.60nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100334BDBM100334(US8501749, 34)
Affinity DataIC50: 2.60nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098874BDBM50098874(4-{2-[5-Amino-2-(3-chloro-phenyl)-6-oxo-6H-pyrimid...)
Affinity DataKi:  2.62nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100337BDBM100337(US8501749, 37)
Affinity DataIC50: 2.70nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100327BDBM100327(US8501749, 27)
Affinity DataIC50: 3nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 134267BDBM134267(US8846660, 41)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068918BDBM50068918((S)-4-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-p...)
Affinity DataKi:  3nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100312BDBM100312(US8501749, 12)
Affinity DataIC50: 3.10nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068899BDBM50068899(3-(4-{[(S)-1-((S)-2-Benzoylamino-3-methyl-butyryl)...)
Affinity DataKi:  3.10nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50332960BDBM50332960((3S,4S)-4-(4-Carboxy)phenoxy-1-[diphenylmethyl)ami...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human ChymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50208225BDBM50208225((E)-2-(3-chlorostyrylamino)-1-(5-chlorobenzo[b]thi...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098868BDBM50098868(4-[2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-a...)
Affinity DataKi:  3.56nMAssay Description:In vitro inhibitory activity was determined against human heart chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098847BDBM50098847(2-(2-{2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyri...)
Affinity DataKi:  3.68nMAssay Description:Inhibitory activity against canine skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50068919BDBM50068919(3-(4-{[(S)-1-(2-tert-Butoxycarbonylamino-4-carboxy...)
Affinity DataKi:  3.90nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50101132BDBM50101132(1,3-Dibenzyl-[1,3]diazetidine-2,4-dione | CHEMBL47...)
Affinity DataIC50: 4nMAssay Description:Compound was evaluated for its inhibitory activity against human Serine protease chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 134262BDBM134262(US8846660, 30)
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the compounds of the present invention for recombinant human chymase was measured by the method of Pasztor et al. (Pasztor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 256012BDBM256012(US9481672, 190 | US20250302837, Example fulacimsta...)
Affinity DataIC50: 4nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100321BDBM100321(US8501749, 21)
Affinity DataIC50: 4nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50208224BDBM50208224(2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carba...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human skin chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50374400BDBM50374400(CHEMBL402185)
Affinity DataKi:  4.80nMAssay Description:Inhibition of human chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 100322BDBM100322(US8501749, 22)
Affinity DataIC50: 4.80nMpH: 8.0 T: 2°CAssay Description:In vitro inhibition assay of Chymase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
US Patent

TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098853BDBM50098853(2-(2-{2-[5-Amino-2-(3-methoxy-phenyl)-6-oxo-6H-pyr...)
Affinity DataKi:  4.85nMAssay Description:Inhibitory activity evaluated against chymase from human heart.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075109BDBM50075109(1,1-dimethyl-2-phenylcarboxamidoheptanoic anhydrid...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against human chymase (h-chymase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098854BDBM50098854(2-{2-[2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)...)
Affinity DataKi:  5.57nMAssay Description:Inhibitory activity evaluated against chymase from human heart.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50374284BDBM50374284(CHEMBL256270)
Affinity DataKi:  5.60nMAssay Description:Inhibition of human chymaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075107BDBM50075107(1,1-dimethyl-4-phenyl-2-propylcarboxamidopentanoic...)
Affinity DataIC50: 5.60nMAssay Description:Inhibitory activity against human chymase (h-chymase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetChymase(Human)
The University of Queensland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50075107BDBM50075107(1,1-dimethyl-4-phenyl-2-propylcarboxamidopentanoic...)
Affinity DataIC50: 5.60nMAssay Description:Inhibitory activity against human chymase (h-chymase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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