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Report error Found 1485 for UniProtKB: P24530
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50208985(CHEMBL3885244)
Affinity DataIC50: 0.00600nMAssay Description:Displacement of [125I]endothelin-1 from human recombinant ETB receptor expressed in CHO cells measured after 120 mins by scintillation counting metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50155245(CHEMBL3774897)
Affinity DataIC50: 0.00600nMAssay Description:Displacement of [125I]Endothelin-1 from human recombinant Endothelin-B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50143784(J-104132 | CHEMBL305576 | (5S,6R,7R)-5-Benzo[1,3]d...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2012
Entry Details
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50197953(CHEMBL3980643)
Affinity DataIC50: 0.100nMAssay Description:Agonist activity at human recombinant ETB receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization by fluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071445(N-[(R)-1-[(S)-2-Ethenesulfonylamino-1-(1H-indol-3-...)
Affinity DataKi:  0.140nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061086((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(3-chloro...)
Affinity DataIC50: 0.140nMAssay Description:Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50000558(Endothelin-1 | ET-1 | Endothelin -1 | c(Cys-Ser-c(...)
Affinity DataIC50: 0.200nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061078((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 0.200nMAssay Description:Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50395673(CHEMBL2165327)
Affinity DataIC50: 0.208nMAssay Description:Displacement of [I125]ET1 from recombinant ETB receptor expressed in CHO cells after 2 hrs by TopCount analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071438((S)-2-[(R)-2-[(3,5-Dimethyl-benzoyl)-methyl-amino]...)
Affinity DataKi:  0.210nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071435((S)-2-[(R)-2-[(3,5-Dimethyl-benzoyl)-methyl-amino]...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071437(N-[(R)-1-[(S)-1-(1H-Indol-3-ylmethyl)-2-oxo-2-(pro...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071423(N-[(R)-1-[(S)-2-(2-Ethoxy-ethanesulfonylamino)-1-(...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071420(N-[(R)-1-[(S)-1-(1H-Indol-3-ylmethyl)-2-oxo-2-(pro...)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071436(N-[(R)-1-[(S)-2-(Butane-1-sulfonylamino)-1-(1H-ind...)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061074((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 0.280nMAssay Description:Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071421(N-[(R)-1-[(S)-2-Benzenesulfonylamino-1-(1H-indol-3...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071439(N-[(R)-1-[(S)-1-(1H-Indol-3-ylmethyl)-2-oxo-2-(pro...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071430(N-[(R)-1-[(S)-2-Ethanesulfonylamino-1-(1H-indol-3-...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071428(N-[(R)-1-{(S)-1-(1H-Indol-3-ylmethyl)-2-oxo-2-[((E...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50197955(CHEMBL1515091)
Affinity DataIC50: 0.410nMAssay Description:Antagonist activity at ETB receptor in human BSMC assessed as inhibition of endothelin-1 or 3-mediated Ca2+ mobilization preincubated for 5 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2018
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061096((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(butane-1...)
Affinity DataIC50: 0.470nMAssay Description:Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061085((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 0.480nMAssay Description:Binding assay performed using human Endothelin B receptor (hETB) expressed in chinese hamster ovary cells(CHO)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071444(N-[(R)-1-[1-(Butane-1-sulfonylaminocarbonyl)-3-met...)
Affinity DataKi:  0.490nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071443(N-[(R)-1-[(S)-1-(1H-Indol-3-ylmethyl)-2-oxo-2-phen...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071440(N-[(R)-1-[2-(Butane-1-sulfonylamino)-1-naphthalen-...)
Affinity DataKi:  0.590nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061096((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(butane-1...)
Affinity DataIC50: 0.600nMAssay Description:Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071432((S)-2-[(R)-2-[(3,5-Dimethyl-benzoyl)-methyl-amino]...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071426(N-[(R)-1-[1-(Butane-1-sulfonylaminocarbonyl)-propy...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080623((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,2-dimethy...)
Affinity DataIC50: 0.710nMAssay Description:Binding ability determined by the displacement of [125 I]ET-3 from the human Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071441((S)-2-[(R)-2-[(3,5-Dimethyl-benzoyl)-methyl-amino]...)
Affinity DataKi:  0.760nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071427((S)-2-[(R)-2-[(3,5-Dimethyl-benzoyl)-methyl-amino]...)
Affinity DataKi:  0.790nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50284769((S)-2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{(S)-2-cycl...)
Affinity DataIC50: 0.800nMAssay Description:Functional inhibition of ET-1 induced [Ca2+] increase in human Girardi heart (hGH) cells, which express Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080589((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,6-diethyl...)
Affinity DataIC50: 0.800nMAssay Description:Binding affinity towards human Endothelin B receptor (hET -B)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061086((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-{2-[(3-chloro...)
Affinity DataIC50: 0.830nMAssay Description:Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080628((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,2-dimethy...)
Affinity DataIC50: 0.940nMAssay Description:Binding ability determined by the displacement of [125 I]ET-3 from the human Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071433((S)-2-{(R)-3-Biphenyl-4-yl-2-[(3,5-dimethyl-benzoy...)
Affinity DataKi:  1nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080619((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(di-o-tolylm...)
Affinity DataIC50: 1.10nMAssay Description:Binding ability determined by the displacement of [125 I]ET-3 from the human Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080597((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,6-diethyl...)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity towards human Endothelin B receptor (hET -B)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50051385(2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{2-cyclopropyl-...)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity towards Endothelin B receptor in human girardi heart cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080597((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,6-diethyl...)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity towards human Endothelin B receptor (hET -B)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080616((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2-ethyl-1-p...)
Affinity DataIC50: 1.10nMAssay Description:Binding ability determined by the displacement of [125 I]ET-3 from the human Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061085((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataIC50: 1.12nMAssay Description:Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071425(N-[(R)-1-[(S)-1-(Butane-1-sulfonylaminocarbonyl)-2...)
Affinity DataKi:  1.20nMAssay Description:Compound was tested for the binding affinity against Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080593((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,6-diethyl...)
Affinity DataIC50: 1.20nMAssay Description:Binding affinity towards human Endothelin B receptor (hET -B)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50249565(CHEMBL4075238)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at ETB receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2019
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080588((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,6-diethyl...)
Affinity DataIC50: 1.20nMAssay Description:Binding affinity towards human Endothelin B receptor (hET -B)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50071425(N-[(R)-1-[(S)-1-(Butane-1-sulfonylaminocarbonyl)-2...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to Endothelin B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50080588((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-[(2,6-diethyl...)
Affinity DataIC50: 1.20nMAssay Description:Binding affinity towards human Endothelin B receptor (hET -B)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50061074((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-2-(3-fluoro-4-m...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human ETB receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 3 hrs by 125I-labelled ET-1 sat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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