Compile Data Set for Download or QSAR
Report error Found 87 of affinity data for UniProtKB/TrEMBL: Q8T9Z7
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22109(CHEMBL1213653 | 7-{[(3R,4R)-3-hydroxy-4-(hydroxyme...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of Plasmodium falciparum purine nucleoside phosphorylase assessed as slow onset inhibition constant by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22109(CHEMBL1213653 | 7-{[(3R,4R)-3-hydroxy-4-(hydroxyme...)
Affinity DataKi:  0.5nM ΔG°:  -52.6kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22109(CHEMBL1213653 | 7-{[(3R,4R)-3-hydroxy-4-(hydroxyme...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of Plasmodium falciparum His-tagged PNP expressed in Escherichia coli assessed as inhibitor constant for enzyme-inhibitor complex formatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of Plasmodium falciparum His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor-substrate complex formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50247158(7-(((3S,4S)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-...)
Affinity DataKi:  0.680nMAssay Description:Inhibition of Plasmodium falciparum His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor-substrate complex formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  0.860nMAssay Description:Inhibition of Plasmodium falciparum PNP expressed in Escherichia coli BL21(DE3) cells by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293087(2-amino-7-(((3R,4R)-3-hydroxy-4-(hydroxymethyl)pyr...)
Affinity DataKi:  0.890nMAssay Description:Inhibition of Plasmodium falciparum His-tagged PNP expressed in Escherichia coli assessed as inhibitor constant for enzyme-inhibitor complex formatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293086(2-amino-7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxym...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of Plasmodium falciparum His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor-substrate complex formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of recombinant Plasmodium falciparum PNP using inosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2016
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293088(7-((2R,3R,4S,5S)-3,4-dihydroxy-5-(hydroxymethyl)py...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of Plasmodium falciparum His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor-substrate complex formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50330391(5-(3-(benzyloxy)benzyl)-1-((2-hydroxyethoxy)methyl...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of Plasmodium falciparum PNP expressed in Escherichia coli BL21(DE3) cells by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50247158(7-(((3S,4S)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of Plasmodium falciparum His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor complex formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50330390(5'-methylthio-immucillin-H | CHEMBL1275659)
Affinity DataKi:  2.70nMAssay Description:Inhibition of Plasmodium falciparum PNP expressed in Escherichia coli BL21(DE3) cells by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50247149(5'-Methylthio-ImmH | CHEMBL473929 | US9290501, (A))
Affinity DataKi:  2.70nMAssay Description:Inhibition of Plasmodium falciparum 3D7 PNP expressed in Escherichia coli assessed as reduction in uric acid formation by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50252865(Immucillins, 1 | (3S,4S)-1-((9-Deazahypoxanthin-9-...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of Plasmodium falciparum purine nucleoside phosphorylase by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50252865(Immucillins, 1 | (3S,4S)-1-((9-Deazahypoxanthin-9-...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of Plasmodium falciparum purine nucleoside phosphorylase by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50247151(7-(((3R,4S)-3-hydroxy-4-(methylthiomethyl)pyrrolid...)
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant Plasmodium falciparum PNP using inosine as substrate by xanthine oxidase coupling enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2016
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293088(7-((2R,3R,4S,5S)-3,4-dihydroxy-5-(hydroxymethyl)py...)
Affinity DataKi:  18nMAssay Description:Inhibition of Plasmodium falciparum His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor complex formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM136306(US8853224, 24)
Affinity DataKd:  19nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50252865(Immucillins, 1 | (3S,4S)-1-((9-Deazahypoxanthin-9-...)
Affinity DataKi:  23.3nMAssay Description:Inhibition of Plasmodium falciparum purine nucleoside phosphorylase assessed as slow onset inhibition constant by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50252865(Immucillins, 1 | (3S,4S)-1-((9-Deazahypoxanthin-9-...)
Affinity DataKi:  23.3nMAssay Description:Inhibition of Plasmodium falciparum purine nucleoside phosphorylase assessed as slow onset inhibition constant by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  29nMAssay Description:Inhibition of Plasmodium falciparum His-tagged PNP assessed as inhibitor constant for enzyme-inhibitor complex formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293091(7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL...)
Affinity DataKd:  55nMAssay Description:Binding affinity to Plasmodium falciparum His6-tagged PNP assessed as reduction in uric acid formation using inosine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293091(7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL...)
Affinity DataKd:  55nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50247158(7-(((3S,4S)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-...)
Affinity DataKi:  80nMAssay Description:Inhibition of Plasmodium falciparum purine nucleoside phosphorylase by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50116358(CHEMBL3604359)
Affinity DataKi:  93nMAssay Description:Inhibition of recombinant Plasmodium falciparum PNP using inosine as substrate assessed as inhibition constant for slow onset inhibition of enzyme-in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2016
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataIC50: 103nMAssay Description:Inhibition of recombinant Plasmodium falciparum PNP incubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293064(Immucillins, 10 | CHEMBL523107 | 7-({[1,3-Dihydrox...)
Affinity DataKd:  163nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22108(7-{[2-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5...)
Affinity DataKi:  191nM ΔG°:  -38.0kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293067(7-({[(2S,3R)-1,3,4-Trihydroxybutan-2-yl]amino}meth...)
Affinity DataKd:  210nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293075(7-({[3-Hydroxy-2-(hydroxymethyl)propyl]amino}methy...)
Affinity DataKd:  210nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50252909(Immucillins, 5 | CHEMBL522870 | (3R,4R)-1-((9-Deaz...)
Affinity DataKi:  260nMAssay Description:Inhibition of Plasmodium falciparum purine nucleoside phosphorylase by xanthine-oxidase coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293071(7-({[(2S)-2,3-Dihydroxypropyl]amino}methyl)-3,5-di...)
Affinity DataKd:  260nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293060(7-{(1S)-1-[(1,3-Dihydroxypropan-2-yl)amino]-2-hydr...)
Affinity DataKd:  297nMAssay Description:Binding affinity to Plasmodium falciparum His6-tagged PNP assessed as reduction in uric acid formation using inosine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293060(7-{(1S)-1-[(1,3-Dihydroxypropan-2-yl)amino]-2-hydr...)
Affinity DataKd:  297nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50116358(CHEMBL3604359)
Affinity DataKi:  298nMAssay Description:Inhibition of recombinant Plasmodium falciparum PNP using inosine as substrate by xanthine oxidase coupling enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2016
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293068(7-{[(2-Hydroxyethyl)amino]methyl}-3,5-dihydro-4H-p...)
Affinity DataKd:  430nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50241515(7-(((3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-...)
Affinity DataKi:  500nMAssay Description:Binding affinity to Plasmodium falciparum 3D7 PNP assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293079(7-({[(2S)-2,3-Dihydroxypropyl](2-hydroxyethyl)amin...)
Affinity DataKd:  550nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22107(7-{[(2R,4R)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  580nM ΔG°:  -35.2kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293077(7-{[(4-Hydroxybutyl)amino]methyl}-3,5-dihydro-4H-p...)
Affinity DataKd:  770nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293083(7-({[(2R/S)-2,4-Dihydroxybutyl](methyl)amino}methy...)
Affinity DataKd:  770nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293072(7-({[(2R,3R)-1,3,4-Trihydroxybutan-2-yl]amino}meth...)
Affinity DataKd:  770nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50195587(CHEMBL218291 | CHEMBL1213652 | 1,4-DIDEOXY-4-AZA-1...)
Affinity DataKi:  860nMAssay Description:Binding affinity to Plasmodium falciparum 3D7 PNP assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293087(2-amino-7-(((3R,4R)-3-hydroxy-4-(hydroxymethyl)pyr...)
Affinity DataKi:  890nMAssay Description:Binding affinity to Plasmodium falciparum 3D7 PNP assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293086(2-amino-7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxym...)
Affinity DataKi:  900nMAssay Description:Binding affinity to Plasmodium falciparum 3D7 PNP assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293063(7-{[(1,3-Dihydroxypropan-2-yl)(2-hydroxyethyl)amin...)
Affinity DataKd:  1.00E+3nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM136312(US8853224, 29)
Affinity DataKd:  1.10E+3nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM22106(7-{[(2R,4S)-2,4-bis(hydroxymethyl)azetidin-1-yl]me...)
Affinity DataKi:  1.29E+3nM ΔG°:  -33.3kJ/molepH: 7.7 T: 2°CAssay Description:PNP activity was monitored by absorbance change in a coupled assay. In the assay, inosine was converted to hypoxanthine, and then hypoxanthine was co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2008
Entry Details Article
PubMed
TargetPurine nucleoside phosphorylase(malaria parasite P. falciparum)
Industrial Research

Curated by ChEMBL
LigandPNGBDBM50293081(7-({[(2R)-2,3-Dihydroxypropyl](2-hydroxyethyl)amin...)
Affinity DataKd:  1.38E+3nMT: 2°CAssay Description:The inhibitor dissociation constants reported in Table 1 below are for phosphorolysis of inosine by PNP and were based on reaction rates measurements...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

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