PMID

Data

Article Title

Organization

Bioactive diterpenoids from Trigonostemon chinensis: Structures, NO inhibitory activities, and interactions with iNOS.

Nankai University

Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.

Northwestern University

Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti-inflammatory/analgesic agents.

Beni-Suef University

New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase.

Stony Brook University

Selective Acetamidine-Based Nitric Oxide Synthase Inhibitors: Synthesis, Docking, and Biological Studies.

University of Chieti&Quot;G. D'Annunzio&Quot

2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity.

Northwestern University

Synthesis and biological evaluation of novel pyrazoline derivatives as potent anti-inflammatory agents.

Sichuan University

Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases.

Sichuan University

Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.

Northwestern University

Structure-based design of bacterial nitric oxide synthase inhibitors.

University of California

Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase.

Northwestern University

Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity.

Northwestern University

Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition.

Northwestern University

Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma.

Northwestern University

Octulosonic acid derivatives from Roman chamomile (Chamaemelum nobile) with activities against inflammation and metabolic disorder.

University of Mississippi

An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors.

Northwestern University

Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.

Universit£

Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.

Northwestern University

In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.

Northwestern University

Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida.

The University of Mississippi

Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.

University of California

Anti-inflammatory lanostanoids and lactone derivatives from Antrodia camphorata.

National Sun Yat-Sen University

Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.

Northwestern University

Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1).

Purdue University

New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714.

Instituto Cajal (Csic)

Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents.

Sichuan University

Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production.

Kangwon National University

Biologically active constituents from the fruiting body of Taiwanofungus camphoratus.

National Formosa University

Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.

Christian-Albrechts-University of Kiel

New diterpenoids and the bioactivity of Erythrophleum fordii.

National Cheng Kung University

Design and synthesis of 7-alkoxy-4-heteroarylamino-3-quinolinecarbonitriles as dual inhibitors of c-Src kinase and nitric oxide synthase.

China Pharmaceutical University

Design, synthesis, and preliminary evaluation of 4-(6-(3-nitroguanidino)hexanamido)pyrrolidine derivatives as potential iNOS inhibitors.

Shandong University

Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.

Northwestern University

Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.

Northwestern University

Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.

Northwestern University

Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases.

Northwestern University

N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase.

Northwestern University

2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS).

Pfizer

Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine.

Northwestern University

Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters.

Northwestern University

L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.

G. D. Searle Research and Development

Approaches toward selective inhibition of nitric oxide synthase.

University of Michigan

1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase.

Northwestern University

Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol.

Purdue University

Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.

Northwestern University

Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors.

Afraxis

Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity.

Kaohsiung Medical University

Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents.

National Cheng Kung University

Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.

University of Hawaii At Hilo

Anti-inflammatory endiandric acid analogues from the roots of Beilschmiedia tsangii.

Kaohsiung Medical University

Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase.

Northwestern University

Oxadiazole derivatives containing 1,4-benzodioxan as potential immunosuppressive agents against RAW264.7 cells.

Nanjing University

Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNO

Kalypsys

Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase.

Northwestern University

Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives for the treatment of inflammatory diseases.

Sichuan University

Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.

Northwestern University

N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.

Università

Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.

Northwestern University

Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.

Northwestern University

Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.

Purdue University

2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I.

University of Pennsylvania

Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.

Northwestern University

 

Synthesis of phosphorus-containing amino acid analogs as inhibitors of nitric oxide synthase

TBA

 

Fungal metabolite of naftazone inhibits nitrite production by activated murine macrophages

TBA

 

1,2-diaminobenzimidazoles : Selective inhibitors of nitric oxide synthase derived from aminoguanidine

TBA

Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.

Northwestern University

Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.

Northwestern University

Synthesis of biflavones having a 6-O-7'' linkage and effects on cyclooxygenase-2 and inducible nitric oxide synthase.

Kangwon National University

The design, synthesis and biological evaluation of 7-alkoxy-4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS.

China Pharmaceutical University

Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.

Université

New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense.

Mansoura University

Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.

Northwestern University

Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors.

Northwestern University

4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor.

Dainippon Pharmaceutical

Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis.

Anhui Medical University

Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines.

Fukui Research Institute

The synthesis and effect of fluorinated chalcone derivatives on nitric oxide production.

Universidad De Valencia

Design and synthesis of new disubstituted benzoxazolone derivatives that act as iNOS inhibitors with potent anti-inflammatory activity against LPS-induced acute lung injury (ALI).

Shanxi Medical University

Ocular Disease Therapeutics: Design and Delivery of Drugs for Diseases of the Eye.

Taipei Medical University

Evaluation of new L-thiocitrulline derivatives as inhibitors of nitric oxide synthase.

Wake Forest University

Examination of N-hydroxylation as a prerequisite mechanism of nitric oxide synthase inactivation.

University At Buffalo

Guanidine-substituted imidazoles as inhibitors of nitric oxide synthase.

Wake Forest University Winston-Salem

Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.

Northwestern University

Synthesis and evaluation of new sulfur-containing L-arginine-derived inhibitors of nitric oxide synthase.

Wake Forest University

Conformationally constrained NO synthase inhibitors: rigid analogs of L-N-iminoethylornithine.

Université

Novel Pyrazolo[4,3- d]pyrimidine as Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model.

Anhui Medical University

First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.

Northwestern University

Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.

Abbott Laboratories

Synthesis and evaluation of two positron-labeled nitric oxide synthase inhibitors, S-[11C]methylisothiourea and S-(2-[18F]fluoroethyl)isothiourea, as potential positron emission tomography tracers.

Washington University

Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.

Northwestern University

Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-?.

Saarland University

Plakolide A, a new gamma-lactone from the marine sponge Plakortis sp.

Harbor Branch Oceanographic Institution

Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma.

University of Chieti "G. D'Annunzio

Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.

Northwestern University

Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.

Northwestern University

Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.

Northwestern University

Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes.

Portland State University

Covalent reactions of wortmannin under physiological conditions.

Massachusetts General Hospital