PMID

Data

Article Title

Organization

Synthesis and biological activity of 4-(diphenylmethyl)-alpha-[(4-quinolinyloxy)methyl]-1-piperazineethanol and related compounds.

Warner-Lambert

Calcium channel blocking and positive inotropic activities of ethyl 5-cyano-1,4-dihydro-6-methyl-2-[(phenylsulfonyl)methyl]-4-aryl-3- pyridine-carboxylate and analogues. Synthesis and structure-activity relationships.

Warner-Lambert

Dihydropyrimidine calcium channel blockers. 2. 3-substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.

Squibb Institute For Medical Research

Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity.

Suntory Institute For Biomedical Research

2-(2-Aryl-2-oxoethylidene)-1,2,3,4-tetrahydropyridines. Novel isomers of 1,4-dihydropyridine calcium channel blockers.

Warner-Lambert

Dimeric 1,4-dihydropyridines as calcium channel antagonists.

State University of New York

Crystal structures and pharmacologic activities of 1,4-dihydropyridine calcium channel antagonists of the isobutyl methyl 2,6-dimethyl-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylate (nisoldipine) series.

University of Oslo

Stereoselectivity of a potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

TBA

Discovery of a Potent Analgesic NOP and Opioid Receptor Agonist: Cebranopadol.

Pharmacokinetics

Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639.

Abbvie

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.

University of Oxford

Vascular L-type Ca²¿ channel blocking activity of sulfur-containing indole alkaloids from Glycosmis petelotii.

Vietnam Academy of Science and Technology

Selective optimization of side activities: another way for drug discovery.

Prestwick Chemical

From hit to lead. Analyzing structure-profile relationships.

Universities of Lille

Synthesis and biological activity of the calcium modulator (R) and (S)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Fourth Military Medical University

 

Phenyl-glycinol based NK₁ receptor antagonists — towards the minimum pharmacophore

TBA

 

Heterocyclic guanidines as calcium antagonists

TBA

 

(cis)-3-methyl-1,5-benzothiazepine-4-ones: potent analogs of the calcium channel blocker diltiazen

TBA

 

CGS 27830, a potent nonpeptide endothelin receptor antagonist

TBA

De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability.

Synaptic Pharmaceutical

Design and biological evaluation of non-peptide analogues of omega-conotoxin MVIIA.

Parke-Davis Neuroscience Research Centre

Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers.

Warner-Lambert

New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H

Universit£

The discovery and optimization of benzimidazoles as selective Na

Pfizer

New purines and purine analogs as modulators of multidrug resistance.

Institut De Recherches Servier

Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric).

Seoul National University

MICE models: superior to the HERG model in predicting Torsade de Pointes.

Chantest

Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.

Solvay Duphar

Asymmetric synthesis and biological evaluations of (+)- and (-)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels.

Ajinomoto Pharmaceuticals

Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker.

Universita Degli Studi Di Perugia

L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives.

Universita Degli Studi Di Bologna

Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening.

Universit£

The structure-activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels.

Ajinomoto

Polycyclic guanidine alkaloids from the marine sponge Crambe crambe and Ca++ channel blocker activity of crambescidin 816.

University of Brussels

Simplified tetrandrine congeners as possible antihypertensive agents with a dual mechanism of action.

Universidad De Chile

Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels.

Ajinomoto

Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke.

Boehringer Ingelheim Pharma

Vasorelaxation by new hybrid compounds containing dihydropyridine and pinacidil-like moieties.

National Academy of Sciences of Ukraine

Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate.

New York University Medical Center

Terpenoids with vasorelaxant effects from the Chinese liverwort Scapania carinthiaca.

Shandong University

Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines.

Warner-Lambert

Design, Synthesis, and Pharmacological Evaluation of Second-Generation Tetrahydroisoquinoline-Based CXCR4 Antagonists with Favorable ADME Properties.

Emory University

4-Isoxazolyl-1,4-dihydropyridines: biological, theoretical, and structural studies.

State University of New York

Benzazepinone calcium channel blockers. 4. Structure-activity overview and intracellular binding site.

Bristol-Myers Squibb Pharmaceutical Research Institute