PMID

Data

Article Title

Organization

Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure.

Universit£

Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents.

India Academy of Scientific & Innovative Research (Acsir)

Synthesis and molecular modelling studies of 8-arylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors.

Cobra

Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors.

Institut De Chimie Des Substances Naturelles

Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors.

Rajiv Gandhi Proudyogiki Vishwavidyalaya

Development of DANDYs, new 3,5-diaryl-7-azaindoles demonstrating potent DYRK1A kinase inhibitory activity.

Upr 2301, Cnrs

Synthesis of novel 7-substituted pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases.

Cobra

Design, synthesis, and molecular modelling of pyridazinone and phthalazinone derivatives as protein kinases inhibitors.

University of Strasburg

Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases.

University of Athens

Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases.

Universit£

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.

Cnrs

A one-pot synthesis and biological activity of ageladine A and analogues.

Macquarie University

Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors.

Universit£

Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Ka inhibitors.

Universit£

Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide.

Universit£

Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases.

Institut De Chimie Des Substances Naturelles (Icsn)

Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex.

University of Oxford

Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.

Universit£

Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents.

Universit£

Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives.

Clermont Universite£

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

Universite£? De Rennes 1

Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones.

Trinity College

Synthesis and kinase inhibitory activity of novel substituted indigoids.

Universit£

Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins.

Clermont Universit£

Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity.

Universit£

DYRK1A inhibitors for disease therapy: Current status and perspectives.

West China Hospital

Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3?/DYRK1A dual inhibitors for the treatment of Alzheimer's disease.

Shenyang Pharmaceutical University

In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition.

Universit£

Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1.

Universit£

Discovery of DB18, a potent inhibitor of CLK kinases with a high selectivity against DYRK1A kinase.

Chemveda Life Sciences India

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis.

Universit£

Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies.

Universit£

Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) Inhibitors as Potential Therapeutics.

Seoul National University

Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition.

University College Cork

Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors.

University of Tours

Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration.

Universit£