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Thiol-based SAHA analogues as potent histone deacetylase inhibitors.

Nagoya City University

Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia.

The University of Tokyo

Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides.

University College London

Novel histone deacetylase inhibitors: design, synthesis, enzyme inhibition, and binding mode study of SAHA-based non-hydroxamates.

Nagoya City University

Heterocyclic ketones as inhibitors of histone deacetylase.

Abbott Laboratories

Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC).

Abbott Laboratories

Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.

West China Hospital of Sichuan University

Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.

China Pharmaceutical University

Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay.

Sungkyunkwan University

Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.

University of Milan

Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity.

Sungkyunkwan University

Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy.

Shenyang Pharmaceutical University

Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study.

Shenyang Pharmaceutical University

Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC.

China Pharmaceutical University

Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.

European Institute of Oncology

Synthesis and biological activity of diisothiocyanate-derived mercapturic acids.

Wroclaw University of Technology

Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase.

China Pharmaceutical University

Triazine as a promising scaffold for its versatile biological behavior.

Thapar University

Natural Product Primary Sulfonamides and Primary Sulfamates.

Griffith University

Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization.

Yonsei University

Macrocyclic compounds as anti-cancer agents: design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2.

Central South University

Indole-3-ethylsulfamoylphenylacrylamides: potent histone deacetylase inhibitors with anti-inflammatory activity.

Taipei Medical University

A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells.

University of Oklahoma

Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity.

Shandong University

Aurones as histone deacetylase inhibitors: identification of key features.

University of Geneva

ST7612AA1, a thioacetate-¿(¿-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.

R&D Sigma-Tau Industrie Farmaceutiche Riunite

Design, synthesis and biological evaluation ofß-boswellic acid based HDAC inhibitors as inducers of cancer cell death.

Csir-Indian Institute of Integrative Medicine

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.

Merck Research Laboratories

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.

Merck Research Laboratories

Therapeutic progression of quinazolines as targeted chemotherapeutic agents.

Panjab University

Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors.

Menoufia University

Synthesis and biological evaluation of aminobenzamides containing purine moiety as class I histone deacetylases inhibitors.

Nanchang University

Discovery of STAT3 and Histone Deacetylase (HDAC) Dual-Pathway Inhibitors for the Treatment of Solid Cancer.

China Pharmaceutical University

Novel bioactive hybrid Celecoxib-HDAC Inhibitor, induces apoptosis in human acute lymphoblastic leukemia cells.

The Affiliated Hospital of Southwest Medical University

2-Aminothiazole: A privileged scaffold for the discovery of anti-cancer agents.

Hunan University of Science and Technology

Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans.

Second Military Medical University

Dual target inhibitors based on EGFR: Promising anticancer agents for the treatment of cancers (2017-).

Zhuhai Campus of Zunyi Medical University

Discovery of Novel Src Homology-2 Domain-Containing Phosphatase 2 and Histone Deacetylase Dual Inhibitors with Potent Antitumor Efficacy and Enhanced Antitumor Immunity.

Shandong University

Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer.

Sun Yat-Sen University

Design, synthesis and antitumor activity study of PARP-1/HDAC dual targeting inhibitors.

Qingdao University Medical College

Paradigm shift of "classical" HDAC inhibitors to "hybrid" HDAC inhibitors in therapeutic interventions.

National Institute of Pharmaceutical Education and Research (NIPER)

First-in-Class Dual Mechanism Ferroptosis-HDAC Inhibitor Hybrids.

University of Toledo

From natural products to HDAC inhibitors: An overview of drug discovery and design strategy.

Chengdu University of Traditional Chinese Medicine

Current status in the discovery of dual BET/HDAC inhibitors.

The First Affiliated Hospital of Zhengzhou University

Current status in the discovery of dual BET/HDAC inhibitors.

The First Affiliated Hospital of Zhengzhou University

Cysteine derivatives as acetyl lysine mimics to inhibit zinc-dependent histone deacetylases for treating cancer.

Guizhou Medical University

Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma.

Southern Medical University

Discovery of DNA-Targeting HDAC Inhibitors with Potent Antitumor Efficacy In Vivo That Trigger Antitumor Immunity.

Shandong University

Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.

Cnrs Erl 9195

Structure-Based Design of a Selective Class I Histone Deacetylase (HDAC) Near-Infrared (NIR) Probe for Epigenetic Regulation Detection in Triple-Negative Breast Cancer (TNBC).

China Pharmaceutical University

Ulleunganilines A-C, Trichostatin Analogues Bearing a Modified Side Chain from

Korea Research Institute of Bioscience and Biotechnology (Kribb)

Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with

University of Navarra

Discovery of novel tubulin/HDAC dual-targeting inhibitors with strong antitumor and antiangiogenic potency.

Children'S Hospital Affiliated To Zhengzhou University

Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.

The Scripps Research Institute

(2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors.

Methylgene

Synergistic induction of apoptosis in resistant head and neck carcinoma and leukemia by alkoxyamide-based histone deacetylase inhibitors.

Heinrich-Heine-Universit£T D£Sseldorf

Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitors.

Taipei Medical University

Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment.

Southern Medical University

Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy.

Shandong First Medical University & Shandong Academy of Medical Sciences

Design, synthesis and evaluation of novel indirubin-based N-hydroxybenzamides, N-hydroxypropenamides and N-hydroxyheptanamides as histone deacetylase inhibitors and antitumor agents.

Hanoi University of Pharmacy

Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo.

Taipei Medical University

Recent advances in the discovery of potent and selective HDAC6 inhibitors.

Shandong University

HDAC-Bax Multiple Ligands Enhance Bax-Dependent Apoptosis in HeLa Cells.

Shandong University

Influence of side-chain changes on histone deacetylase inhibitory and cytotoxicity activities of curcuminoid derivatives.

Khon Kaen University

Environment-sensitive fluorescent inhibitors of histone deacetylase.

Shandong University

Quinolone hybrids and their anti-cancer activities: An overview.

Qilu University of Technology (Shandong Academy of Sciences)

Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells.

Heinrich-Heine-Universit£T D£Sseldorf

Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview.

Jadavpur University

Design, synthesis and activity evaluation of indole-based double - Branched HDAC1 inhibitors.

Shandong University

Synthesis, biological evaluation and molecular modeling studies of psammaplin A and its analogs as potent histone deacetylases inhibitors and cytotoxic agents.

Shenyang Pharmaceutical University

HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors.

Indian Csir-Central Drug Research Institute

Novel ?,?-unsaturated hydroxamic acid derivatives overcome cisplatin resistance.

Heinrich-Heine-University D£Sseldorf

Extending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling.

Umr Cnrs 7285

Thioether-based 2-aminobenzamide derivatives: Novel HDAC inhibitors with potent in vitro and in vivo antitumor activity.

Beijing University of Chemical Technology

Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors.

Qingdao University

Design, synthesis and biological evaluation of novel thioquinazolinone-based 2-aminobenzamide derivatives as potent histone deacetylase (HDAC) inhibitors.

Beijing University of Chemical Technology

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-? induced PD-L1 expression.

Taipei Medical University

Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies.

Shandong University

Discovery of Novel Fungal Lanosterol 14?-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasis.

Second Military Medical University

Indole: A privileged scaffold for the design of anti-cancer agents.

Hunan University of Science and Technology

Kinase and Histone Deacetylase Hybrid Inhibitors for Cancer Therapy.

Qingdao University

Synthesis of Peptoid-Based Class I-Selective Histone Deacetylase Inhibitors with Chemosensitizing Properties.

Heinrich-Heine-Universit£T D£Sseldorf

Overview of Recent Strategic Advances in Medicinal Chemistry.

Shandong University

Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors.

Mashhad University of Medical Sciences

Novel ?-Carboline/Hydroxamic Acid Hybrids Targeting Both Histone Deacetylase and DNA Display High Anticancer Activity via Regulation of the p53 Signaling Pathway.

China Pharmaceutical University

Search for novel histone deacetylase inhibitors. Part II: design and synthesis of novel isoferulic acid derivatives.

Xi'An Jiaotong University

Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design.

Wayne State University

Synthesis and anticancer activities of thieno[3,2-d]pyrimidines as novel HDAC inhibitors.

Nantong University

Design, synthesis and biological evaluation of di-substituted cinnamic hydroxamic acids bearing urea/thiourea unit as potent histone deacetylase inhibitors.

Central South University

Development of novel ferulic acid derivatives as potent histone deacetylase inhibitors.

Xi'An Jiaotong University

Novel N-hydroxyfurylacrylamide-based histone deacetylase (HDAC) inhibitors with branched CAP group (Part 2).

China Pharmaceutical University

Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring.

University of Florence

Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 1: hit identification.

Menarini Ricerche

Discovery of a small molecular compound simultaneously targeting RXR and HADC: design, synthesis, molecular docking and bioassay.

Shenyang Pharmaceutical University

Design, synthesis and biological evaluation of indeno[1,2-d]thiazole derivatives as potent histone deacetylase inhibitors.

Central South University

Dual-acting histone deacetylase-topoisomerase I inhibitors.

Georgia Institute of Technology

Set-up of a new series of HDAC inhibitors: the 5,11-dihydrodibenzo[b,e]azepin-6-ones as privileged structures.

Menarini Ricerche Pomezia

Discovery and extensive in vitro evaluations of NK-HDAC-1: a chiral histone deacetylase inhibitor as a promising lead.

Nankai University

Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.

London School of Hygiene and Tropical Medicine

4-N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors.

Menarini Ricerche Pomezia

Structure-based optimization of click-based histone deacetylase inhibitors.

Nankai University

Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors.

Menarini Ricerche Pomezia

Antiproliferative and differentiating activities of a novel series of histone deacetylase inhibitors.

Menarini Ricerche

Novel inhibitor of Plasmodium histone deacetylase that cures P. berghei-infected mice.

Georgetown University Medical Center

Discovery of 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate as a potential antiproliferative agent by inhibiting histone deacetylase.

Nanjing University

Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.

The Scripps Research Institute

New aryldithiolethione derivatives as potent histone deacetylase inhibitors.

Sulfidris

SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors.

Pennsylvania State Hershey College of Medicine

Fluoroalkene modification of mercaptoacetamide-based histone deacetylase inhibitors.

Saga University

Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group.

Georgia Institute of Technology

Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.

Congenia

Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.

Hacettepe University

Recent advances in the development of polyamine analogues as antitumor agents.

Johns Hopkins University

Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases.

Universita Degli Studi Del Piemonte Orientale A. Avogadro

Alpha-mercaptoketone based histone deacetylase inhibitors.

Kalypsys

Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group.

Georgia Institute of Technology

Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors.

Wayne State University

New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity.

Sulfidris

Modification of cap group in delta-lactam-based histone deacetylase (HDAC) inhibitors.

Korea Research Institute of Bioscience and Biotechnology

Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors.

Entremed

Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera.

Wonkwang University

Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors.

Nagoya City University

Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid.

Wayne State University

Structure-activity relationship studies of a series of novel delta-lactam-based histone deacetylase inhibitors.

Kribb

Synthesis, enzymatic inhibition, and cancer cell growth inhibition of novel delta-lactam-based histone deacetylase (HDAC) inhibitors.

Korea Research Institute of Bioscience and Biotechnology

Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides.

University College London

Alkyl-substituted polyaminohydroxamic acids: a novel class of targeted histone deacetylase inhibitors.

Wayne State University

Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates.

Nagoya City University

Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors.

The Ohio State University

Subtype selective substrates for histone deacetylases.

Westf£Lische Wilhelms-Universit£T M£Nster

Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors.

Miikana Therapeutics

Identification of a potent non-hydroxamate histone deacetylase inhibitor by mechanism-based drug design.

Nagoya City University

Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors.

The Ohio State University

Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors.

In2Gen

N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824).

Novartis Institute For Biomedical Research

Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates.

TBA

Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives.

Mitsui Pharmaceuticals

From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy.

Pak Research Center

Histone Deacetylase Inhibitors as Treatment for Targeting Multiple Components in Cancer Therapy.

Usona Institute

Biocompatible Boron-Containing Prodrugs of Belinostat for the Potential Treatment of Solid Tumors.

Xavier University of Louisiana

Design, synthesis and biological evaluation of novel 2-aminobenzamides containing dithiocarbamate moiety as histone deacetylase inhibitors and potent antitumor agents.

Beijing University of Chemical Technology

The structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity.

Wayne State University

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC.

Taipei Medical University

Structure optimization and preliminary bioactivity evaluation of N-hydroxybenzamide-based HDAC inhibitors with Y-shaped cap.

Shandong University

Design, synthesis and biological evaluation of novel hydroxamic acid based histone deacetylase 6 selective inhibitors bearing phenylpyrazol scaffold as surface recognition motif.

Shenyang Pharmaceutical University

Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms.

Mazandaran University of Medical Sciences

Discovery of Novel Pazopanib-Based HDAC and VEGFR Dual Inhibitors Targeting Cancer Epigenetics and Angiogenesis Simultaneously.

Shandong University

Novel Polyamine-Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming.

Alma Mater Studiorum-University of Bologna

Serendipitous discovery of potent human head and neck squamous cell carcinoma anti-cancer molecules: A fortunate failure of a rational molecular design.

Universit£