42 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Synthesis and T-type calcium channel-blocking effects of aryl(1,5-disubstituted-pyrazol-3-yl)methyl sulfonamides for neuropathic pain treatment.
Korea Institute of Science & Technology (Kist)
Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers.
Actelion Pharmaceuticals
Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers.
Actelion Pharmaceuticals
3-Benzamides and 3,4,5-trimethoxyphenyl amines as calcium channel blockers.
Ewha Womans University
Inhibition of cellular proliferation and induction of apoptosis in human lung adenocarcinoma A549 cells by T-type calcium channel antagonist.
Kyung Hee University
Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl)piperazine derivatives as T-type calcium channel blockers.
Korea Institute of Science and Technology
3D QSAR studies on 3,4-dihydroquinazolines as T-type calcium channel blocker by comparative molecular similarity indices analysis (CoMSIA).
Kyung Hee University
Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers.
Institute of Science and Technology
Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers.
Institute of Science and Technology
Synthesis and biological activity of 3,4-dihydroquinazolines for selective T-type Ca2+ channel blockers.
Korea Institute of Science & Technology
In vivo evaluation of oral anti-tumoral effect of 3,4-dihydroquinazoline derivative on solid tumor.
Kyung Hee University
Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers.
Korea Institute of Science and Technology
Synthesis and pharmacological evaluation of 1-alkyl-N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents.
Astellas Pharma
Pyridyl amides as potent inhibitors of T-type calcium channels.
Merck Research Laboratories
Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers.
Institute of Science and Technology
Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity.
Ewha Womans University
Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers.
Institute of Science and Technology
Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
Merck Research Laboratories
Synthesis and evaluation of alpha,alpha'-disubstituted phenylacetate derivatives for T-type calcium channel blockers.
Institute of Science and Technology
T-type Ca2+ channel blockers suppress the growth of human cancer cells.
Kyung Hee University
Lead discovery and optimization of T-type calcium channel blockers.
Institute of Science and Technology
3D pharmacophore based virtual screening of T-type calcium channel blockers.
Institute of Science and Technology
Synthesis and biological evaluation of novel T-type calcium channel blockers.
Kyung Hee University
Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives.
Institute of Science and Technology
Morpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers.
Institute of Science and Technology
Discovery of small-molecule compounds and natural products against Parkinson's disease: Pathological mechanism and structural modification.
Zhejiang University
3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers.
Institute of Science & Technology
In vitro synergistic anticancer activity of the combination of T-type calcium channel blocker and chemotherapeutic agent in A549 cells.
Kyung Hee University
Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers.
Kyung Hee University
Synthesis and evaluation of 6-pyrazoylamido-3N-substituted azabicyclo[3,1,0]hexane derivatives as T-type calcium channel inhibitors for treatment of neuropathic pain.
Korea Institute of Science & Technology (Kist)
Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model.
Korea Institute of Science and Technology
Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Ca
Chinese Academy of Sciences
Successful reduction of off-target hERG toxicity by structural modification of a T-type calcium channel blocker.
The Catholic University of Korea
In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers.
Kyung Hee University
Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers.
University of Toyama
Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.
Idorsia Pharmaceuticals
