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84 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

Article Title
Top-down Targeted Metabolomics Reveals a Sulfur-Containing Metabolite with Inhibitory Activity against Angiotensin-Converting Enzyme in Asparagus officinalis.EBI
Riken Center For Sustainable Resource Science
CoMFA and CoMSIA analysis of ACE-inhibitory, antimicrobial and bitter-tasting peptides.EBI
Tianjin University
Interkingdom pharmacology of Angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes.EBI
Vanderbilt University Department Of Chemistry
Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid- hydrolysis.EBI
University Of Lille
Organosilicon molecules with medicinal applications.EBI
University Of California Davis
Chemical and pharmaceutical studies on medicinal plants in Paraguay. Geraniin, an angiotensin-converting enzyme inhibitor from "paraparai mi," Phyllanthus niruri.EBI
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.EBI
Validation of EGSITE2, a mixed integer program for deducing objective site models for experimental binding data.EBI
University Of Michigan
Amino acid side chain descriptors for quantitative structure-activity relationship studies of peptide analogues.EBI
University Of Illinois At Chicago
Three-dimensional quantitative structure-activity relationship of angiotesin-converting enzyme and thermolysin inhibitors. II. A comparison of CoMFA models incorporating molecular orbital fields and desolvation free energies based on active-analog and complementary-receptor-field alignment rules.EBI
Washington University
Dual metalloprotease inhibitors. III. utilization of bicyclic and monocyclic diazepinone based mercaptoacetylsEBI
Dual metalloprotease inhibitors. II. Effect of substitution and stereochemistry on benzazepinone based mercaptoacetylsEBI
Dual metalloprotease inhibitors. I. constrained peptidomimetics of mercaptoacyl dipeptidesEBI
Synopsis of some recent tactical application of bioisosteres in drug design.EBI
Bristol-Myers Squibb Pharmaceutical Research And Development
Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.EBI
Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase.EBI
Aarhus University
Remarkable potential of thea-aminophosphonate/phosphinate structural motif in medicinal chemistry.EBI
Wroclaw University Of Technology
Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.EBI
University Of Florida
Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors.EBI
Dipartimento Di Chimica
Targeting ACE and ECE with dual acting inhibitors.EBI
Designed multiple ligands. An emerging drug discovery paradigm.EBI
Organon Laboratories
Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.EBI
University Institute Of Pathology
Computer-aided selection of potential antihypertensive compounds with dual mechanism of action.EBI
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences
2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery.EBI
Merck Research Laboratories
Protease inhibitors: current status and future prospects.EBI
University Of Queensland
Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents.EBI
F. Hoffmann-La Roche
Mixture-based synthetic combinatorial libraries.EBI
Torrey Pines Institute For Molecular Studies
New thiol inhibitors of neutral endopeptidase EC synthesis and enzyme active-site recognition.EBI
University Of Paris
Excursions in drug discovery.EBI
Merck Research Laboratories
Molecular and crystal structures of MDL27,467A hydrochloride and quinapril hydrochloride, two ester derivatives of potent angiotensin converting enzyme inhibitors.EBI
University Of Calgary
Angiotensin converting enzyme inhibitors: spirapril and related compounds.EBI
Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements.EBI
University Of Wisconsin-Madison
Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives.EBI
Tanabe Seiyaku Co.
Conformationally restricted inhibitors of angiotensin converting enzyme: synthesis and computations.EBI
Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types.EBI
Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme.EBI
Conformational analysis and active site modelling of angiotensin-converting enzyme inhibitors.EBI
Angiotensin converting enzyme inhibitors: structure-activity profile of 1-benzazepin-2-one derivatives.EBI
4-Substituted proline derivatives that inhibit angiotensin converting enzyme and neutral endopeptidase 24.11.EBI
Thiol and hydroxamic acid containing inhibitors of endothelin converting enzymeEBI
Blockade of X4-tropic HIV-1 cellular entry by GSK812397, a potent noncompetitive CXCR4 receptor antagonist.EBI
Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors.EBI
The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.EBI
Gsk Medicines Research Centre
Inhibition of Angiotensin-I-Converting Enzyme by Tetrahydroxyxanthones Isolated from Tripterospermum lanceolatumEBI
Novel low molecular renin inhibitors which show good oral blood pressure lowering effects in marmosetsEBI
The design of a dipeptide library for screening at peptide receptor sitesEBI
Synthesis of 6-amino-5-oxo-7-phenyl-1,4-oxazepines as conformationally constrained gauche (−) dipeptide mimeticsEBI
An acyliminium ion route to Cis and Trans "Anti" phe-gly dipeptide mimeticsEBI
Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors.EBI
Santen Pharmaceutical
Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.EBI
University Of Athens
Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides.EBI
University Of Leipzig
Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors.EBI
Santen Pharmaceutical
Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors.EBI
University Of Cape Town
Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection.EBI
Kingston University
Synthesis and molecular modeling of a lisinopril-tryptophan analogue inhibitor of angiotensin I-converting enzyme.EBI
University Of Cape Town
Structure-activity relationship study between Ornithyl-Proline and Lysyl-Proline based tripeptidomimics as angiotensin-converting enzyme inhibitors.EBI
Institute Of Genomics And Integrative Biology
Zinc enzymes in medicinal chemistry.EBI
Hefei University Of Technology
Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.EBI
F. Hoffmann-La Roche
Natural products from mangrove sediments-derived microbes: Structural diversity, bioactivities, biosynthesis, and total synthesis.EBI
Chinese Academy Of Sciences
Bradykinin-Potentiating Peptide-Paclitaxel Conjugate Directed at Ectopically Expressed Angiotensin-Converting Enzyme in Triple-Negative Breast Cancer.EBI
Hong Kong Baptist University
Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition.EBI
University Of Cape Town
Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor.EBI
British Biotech Pharmaceuticals
2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors.EBI
F. Hoffmann-La Roche
Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.EBI
Roche Pharma Research And Early Development
Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin-Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme.EBI
University Of Bath
1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio.EBI
Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives.EBI
Meta-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.EBI
Discovery of TD-0212, an Orally Active Dual Pharmacology ATEBI
Theravance Biopharma Us
Exploration of neutral endopeptidase active site by a series of new thiol-containing inhibitors.EBI
University Of Paris
Experimental confirmation of new drug-target interactions predicted by Drug Profile Matching.EBI
E£Tv£S Lor£Nd University
Perindopril and ramipril phosphonate analogues as a new class of angiotensin converting enzyme inhibitors.EBI
Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives.EBI
Schering-Plough Research Institute
PRO_LIGAND: an approach to de novo molecular design. 2. Design of novel molecules from molecular field analysis (MFA) models and pharmacophores.EBI
Proteus Molecular Design
The molecular basis for the selection of captopril cis and trans conformations by angiotensin I converting enzyme.EBI
Mrc Laboratory Of Molecular Biology, Hills Road, Cambridge, Cb2 2Qh
Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design.EBI
University Of Bath
Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds.EBI
Csir-National Chemical Laboratory
Metabolomics-Guided Discovery of Microginin Peptides from Cultures of the Cyanobacterium Microcystis aeruginosa.EBI
University Of North Carolina Wilmington
Therapeutic investigations of novel indoxyl-based indolines: A drug target validation and Structure-Activity Relationship of angiotensin-converting enzyme inhibitors with cardiovascular regulation and thrombolytic potential.EBI
Vit University
Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome.EBI
Ranbaxy Laboratories