Compile Data Set for Download or QSAR
Report error Found 317 Enz. Inhib. hit(s) with all data for entry = 50027176
LigandPNGBDBM50227856((3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)met...)
Affinity DataKi:  0.150nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50265078((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
Affinity DataKi:  0.190nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetStromelysin-3(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50265077((S)-3-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2...)
Affinity DataKi:  0.230nMAssay Description:Inhibition of MMP11More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50183715(N-(4-(2-(hydroxyamino)-2-oxoethyl)tetrahydro-2H-py...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50194279(4-(2-(4-(4-(5-(2-methoxyethyl)-2,4,6-trioxohexahyd...)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26526(BMCL181958 Compound 1 | CHEMBL148169 | (2R)-N-hydr...)
Affinity DataKi:  0.560nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50265079(CHEMBL496942 | 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLP...)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInterstitial collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50216802((3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(methylsulfonyl...)
Affinity DataKi:  1nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26575((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)py...)
Affinity DataIC50: 1nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50264776((2S,3R)-N1-hydroxy-N4-((1S,2R)-2-hydroxy-2,3-dihyd...)
Affinity DataKi: <1nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetStromelysin-1(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50227709(N-hydroxy-2-(4-(4-(6-(2-hydroxyethoxy)pyridin-2-yl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM23500(CHEMBL209970 | 4-({[4-(but-2-yn-1-yloxy)benzene]su...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50265076((R)-2-(4'-((5-bromo-4-methoxy-3-methylbenzofuran-2...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50195898(4-((2-methylquinolin-4-yl)methoxy)-N-((5-(4-(methy...)
Affinity DataIC50: 2nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50264814((2R,3S)-2-(4-(but-2-ynyloxy)phenylsulfonamido)-N,3...)
Affinity DataIC50: 2nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetStromelysin-1(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50265037((R)-N4-hydroxy-N1-((S)-1-((S)-2-methoxy-1-phenylet...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50264815(4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(3,5...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50265114(N-((2R,6S)-4-(2-(hydroxyamino)-2-oxoethyl)-2,6-dim...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50213944(isobutyl 3-((4-(but-2-ynyloxy)phenylsulfonyl)methy...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50100927((S)-N-(1-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)...)
Affinity DataIC50: 4nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetStromelysin-1(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50097263((R)-N*1*-[(S)-2,2-Dimethyl-1-((R)-1-phenyl-ethylca...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50146472(N-hydroxy-N-(1-(1-isobutylpiperidin-4-ylidene)-3-(...)
Affinity DataIC50: 6nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50081864((2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-2-((N-meth...)
Affinity DataIC50: 6nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50265113((2R,3R)-N3-hydroxy-1-methyl-N2-(4-((2-methylquinol...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50234348(4-((6-(4-methoxybenzylcarbamoyl)-4-oxopyrido[3,4-d...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM23484(CHEMBL410462 | methyl (1R,2S)-2-(hydroxycarbamoyl)...)
Affinity DataKi:  8nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50208340(4-((2-methylquinolin-4-yl)methoxy)-N-(2-(2-oxo-2,3...)
Affinity DataIC50: 9nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26554(3-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}propane-1...)
Affinity DataKi:  10nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBone morphogenetic protein 1(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50216802((3R)-6-cyclohexyl-N-hydroxy-3-(3-{[(methylsulfonyl...)
Affinity DataKi:  11nMAssay Description:Inhibition of BMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50161331(2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-hydro...)
Affinity DataIC50: 12nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM23454(CHEMBL270558 | methyl (1R,2R)-2-(hydroxycarbamoyl)...)
Affinity DataKi:  12nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50264809(Thiirane, 1 | Thiirane (deuterium), 1-d2 | CHEMBL4...)
Affinity DataKi:  14nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50203527(methyl (6S,7S)-7-[(hydroxyamino)carbonyl]-6-[(4-ph...)
Affinity DataIC50: 14nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50264813((R)-3-phenyl-3-(4-(4-(pyridin-4-yl)phenyl)thiophen...)
Affinity DataIC50: 14nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26526(BMCL181958 Compound 1 | CHEMBL148169 | (2R)-N-hydr...)
Affinity DataKi:  15nMAssay Description:Inhibition of ADAM33More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50265077((S)-3-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2...)
Affinity DataKi:  16nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50264810(N-(4-(4-(thiiran-2-ylmethylsulfonyl)phenoxy)phenyl...)
Affinity DataKi:  16nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50064344((3S,5R,14S)-14-(methylcarbamoyl)-2,8-dioxo-3-phene...)
Affinity DataKi:  17nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50203527(methyl (6S,7S)-7-[(hydroxyamino)carbonyl]-6-[(4-ph...)
Affinity DataIC50: 17nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50103175(N-hydroxy-2-(4'-methoxy-N-(pyridin-3-ylmethyl)biph...)
Affinity DataIC50: 18nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetStromelysin-1(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50264772(AM-6 | CHEMBL489603 | 3-Hydroxy-6-methyl-4-oxo-4H-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50203527(methyl (6S,7S)-7-[(hydroxyamino)carbonyl]-6-[(4-ph...)
Affinity DataIC50: 22nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetStromelysin-1(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50227718((R)-3-[(S)-1-((S)-2-methoxy-1-phenyl-ethylcarbamoy...)
Affinity DataIC50: 23nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrilysin(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50183715(N-(4-(2-(hydroxyamino)-2-oxoethyl)tetrahydro-2H-py...)
Affinity DataKi:  25nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50264775((R)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylph...)
Affinity DataIC50: 26nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50265077((S)-3-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2...)
Affinity DataKi:  30nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50234334(benzyl 6-benzyl-5,7-dioxo-6,7-dihydro-5H-thiazolo[...)
Affinity DataIC50: 30nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target72 kDa type IV collagenase(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50203527(methyl (6S,7S)-7-[(hydroxyamino)carbonyl]-6-[(4-ph...)
Affinity DataIC50: 35nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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