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37 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Synthesis and alpha-adrenergic activities of 2- and 4-substituted imidazoline and imidazole analogues.EBI
Ohio State University
Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquino[2,1-g][1 ,6] naphthyridines at alpha-adrenoceptors.EBI
Syntex Research
New 1,4-dihydropyridine derivatives combining calcium antagonism and alpha-adrenolytic properties.EBI
Institut De Pharmacologie (Ua 589 Cnrs)
Radioiodinated p-iodoclonidine: a high-affinity probe for the alpha 2-adrenergic receptor.EBI
TBA
Conformationally defined adrenergic agents. 4. 1-(aminomethyl)phthalans: synthesis and pharmacological consequences of the phthalan ring oxygen atom.EBI
TBA
Synthesis and adrenergic activity of ring-fluorinated phenylephrines.EBI
TBA
Development of an affinity ligand for purification of alpha 2-adrenoceptors from human platelet membranes.EBI
TBA
Therapeutic Potential of 5-HT6 Receptor Agonists.EBI
Universit£
Synthesis and biological evaluation of 2-aryliminopyrrolidines as selective ligands for I1 imidazoline receptors: discovery of new sympatho-inhibitory hypotensive agents with potential beneficial effects in metabolic syndrome.EBI
Universit£
a2-adrenoceptor antagonists: synthesis, pharmacological evaluation, and molecular modeling investigation of pyridinoguanidine, pyridino-2-aminoimidazoline and their derivatives.EBI
Trinity College
Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies.EBI
Universit£
Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists.EBI
Pfizer
Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750.EBI
Pfizer
Selective optimization of side activities: another way for drug discovery.EBI
Prestwick Chemical
Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands.EBI
Abbott Laboratories
Syntheses and adrenergic activities of ring-fluorinated epinephrines.EBI
National Institute Of Diabetes
N-[2-hydroxy-5-[2-(methylamino)ethyl]phenyl]methanesulfonamide. A potent agonist which releases intracellular calcium by activation of alpha 1-adrenoceptors.EBI
TBA
(+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.EBI
Virginia Commonwealth University
 
The synthesis and biological activity of some known and putative metabolites of the atypical antipsychotic agent olanzapine (LY170053)EBI
TBA
 
The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonists.EBI
TBA
Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.EBI
Merck
Indolebutylamines as selective 5-HT(1A) agonists.EBI
Merck
Bridgehead-methyl analog of SC-53116 as a 5-HT4 agonist.EBI
Pfizer
1H-Pyrazolo-[3,4-c]cyclophepta[1,2-c]thiophenes: a unique structural class of dopamine D4 selective ligands.EBI
Neurogen
Substituted conformationally restricted guanidine derivatives: Probing the ?2-adrenoceptors' binding pocket.EBI
Trinity College
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor ligands: searching for structure-activity relationships.EBI
University Of Dublin
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha(2)-adrenoceptor antagonists, 1: toward new antidepressants with heteroatomic linkers.EBI
University Of Dublin
Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues.EBI
Universit£
Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine.EBI
Ohio State University
Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists.EBI
Glaxo Research And Development
Thiophene/thiazole-benzene replacement on guanidine derivatives targeting?EBI
Trinity College
Return of DEBI
University Of Nebraska Medical Center
 
Novel 2(3H)-benzothiazolones as highly potent and selective sigma-1 receptor ligandsBDB
Universite De Lille