BDBM50146167 Capmatinib::INC-280::INCB-28060::NVP-INC280::US10738052, Example 7::US11261191, Example 7::US20240294535, Compound Capmatinib::US9944645, 7
SMILES CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
InChI Key InChIKey=LIOLIMKSCNQPLV-UHFFFAOYSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50146167
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Affinity DataIC50: 0.00400nMAssay Description:Experimental methods: Enzyme reaction substrate, poly(Glu, Tyr)sodium salt (Glu:Tyr=4:1) was diluted with potassium-free phosphate buffered saline (P...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Affinity DataIC50: 0.130nMAssay Description:Inhibition of human Nav1.2 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Affinity DataIC50: 0.130nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Affinity DataIC50: 0.130nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Affinity DataIC50: 0.130nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Affinity DataIC50: 0.400nMAssay Description:Inhibition of c-MET (unknown origin) using TK substrate-biotin peptide as substrate preincubated for 5 to 10 mins followed by ATP addition measured a...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal GST-tagged wild-type human c-MET (956 to 1390 residues) extracted from baculovirus infected Sf21 cells using 5-FAM-KKKKEEIYF...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Affinity DataIC50: 500nMAssay Description:Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Affinity DataIC50: 500nMAssay Description:Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Affinity DataIC50: 500nMAssay Description:Briefly, histidine-tagged c-Met catalytic domain fusion protein was used for the assay. IC50 measurements were based on the degree of phosphorylation...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Human)
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Yunbaiyao Zhengwu Science and Technology (Shanghai) Co.
US Patent
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human c-MET D1228N mutant (956 to end residues) extracted from baculovirus infected Sf9 cells using 5...More data for this Ligand-Target Pair