BindingDB BDBM10881 CHEMBL288100::MZA3::Methazolamide::Methazolamide (MZA)::Methazolamide, MZA::N-[(2Z)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide::Sulfonamide, 2::cid

BDBM10881 CHEMBL288100::MZA3::Methazolamide::Methazolamide (MZA)::Methazolamide, MZA::N-[(2Z)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide::Sulfonamide, 2::cid_4100::sulfonamide 2

SMILES CC(=O)N=c1sc(nn1C)S(N)(=O)=O

InChI Key InChIKey=FLOSMHQXBMRNHR-UHFFFAOYSA-N

Data 290 KI 9 IC50 2 EC50

PDB links: 7 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 10881

Carbonic anhydrase 7(Homo sapiens (Human))
Universite Montpellier Ii

BDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)

Ki: 2.10nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair

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Carbonic anhydrase 12(Homo sapiens (Human))
Universite Montpellier Ii

BDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)

Ki: 3.40nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair

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Carbonic anhydrase 2(Homo sapiens (Human))
Universite Montpellier Ii

BDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)

Ki: 14nM ΔG°: -10.6kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 13(Mus musculus (mouse))
Universite Montpellier Ii

BDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)

Ki: 19nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair

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Carbonic anhydrase 9(Homo sapiens (Human))
Universite Montpellier Ii

BDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)

Ki: 27nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Carbonic anhydrase 14(Homo sapiens (Human))
Universite Montpellier Ii

BDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)

Ki: 43nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair

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Carbonic anhydrase 1(Homo sapiens (Human))
Universite Montpellier Ii

BDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)

Ki: 50nM ΔG°: -9.85kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 5B, mitochondrial(Homo sapiens (Human))
Universite Montpellier Ii

BDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)

Ki: 62nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair

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Carbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
Universite Montpellier Ii

BDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)

Ki: 65nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair

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Carbonic anhydrase 4(Homo sapiens (Human))
Universite Montpellier Ii

BDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)

Ki: 6.20E+3nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair

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3D Structure (crystal)

Filter my 300 hits

Targets 18▿
- Carbonic anhydrase 2 80
- Carbonic anhydrase 1 72
- Carbonic anhydrase 9 41
- Carbonic anhydrase 4 24
- Carbonic anhydrase 12 16
- Carbonic anhydrase 13
- Carbonic anhydrase 14 8
- Carbonic anhydrase 5A, mitochondrial 8
- Carbonic anhydrase 13 7
- Carbonic anhydrase 7 7
- Carbonic anhydrase 6 6
- Carbonic anhydrase 3 6
- Carbonic anhydrase 5B, mitochondrial 6
- Beta-carbonic anhydrase 1 2
- Corticotropin-releasing factor-binding protein 1
- Carbonic anhydrase 15 [19-324] 1
- CARBONIC ANHYDRASE 1
- Delta carbonic anhydrase 1
- ...
Publications 50▿
- Bioorg Med Chem Lett 18: 2669-74 (2008) 12
- Bioorg Med Chem 15: 4336-50 (2007) 12
- Bioorg Med Chem Lett 19: 1371-5 (2009) 12
- J Med Chem 49: 7024-31 (2006) 10
- Bioorg Med Chem Lett 14: 6001-6 (2004) 6
- Eur J Med Chem 45: 2396-404 (2010) 5
- Bioorg Med Chem Lett 16: 437-42 (2005) 5
- J Enzyme Inhib Med Chem 19: 269-73 (2004) 5
- Eur J Med Chem 46: 4403-10 (2011) 5
- Bioorg Med Chem Lett 21: 710-4 (2011) 5
- Bioorg Med Chem 19: 3732-8 (2011) 5
- J Med Chem 47: 1272-9 (2004) 4
- Bioorg Med Chem Lett 13: 1005-9 (2003) 4
- Bioorg Med Chem Lett 14: 869-73 (2004) 4
- Bioorg Med Chem Lett 14: 217-23 (2003) 4
- Bioorg Med Chem Lett 15: 1149-54 (2005) 4
- Bioorg Med Chem Lett 15: 3096-101 (2005) 4
- Bioorg Med Chem Lett 16: 4846-51 (2006) 4
- Bioorg Med Chem Lett 18: 836-41 (2008) 4
- J Med Chem 46: 2187-96 (2003) 4
- J Enzyme Inhib Med Chem 24: 499-505 (2009) 4
- Eur J Med Chem 45: 3656-61 (2010) 4
- Bioorg Med Chem Lett 15: 971-6 (2005) 4
- Bioorg Med Chem Lett 14: 3757-62 (2004) 4
- Bioorg Med Chem Lett 21: 1334-7 (2011) 4
- J Med Chem 50: 381-8 (2007) 4
- Bioorg Med Chem Lett 12: 1551-7 (2002) 3
- J Med Chem 47: 2796-804 (2004) 3
- Bioorg Med Chem 17: 1158-63 (2009) 3
- Bioorg Med Chem Lett 15: 3102-8 (2005) 3
- Bioorg Med Chem Lett 18: 3475-80 (2008) 3
- Bioorg Med Chem Lett 17: 5032-5 (2007) 3
- Bioorg Med Chem Lett 14: 337-41 (2003) 3
- Bioorg Med Chem Lett 13: 841-5 (2003) 3
- J Med Chem 49: 5544-51 (2006) 3
- Bioorg Med Chem Lett 14: 5775-80 (2004) 3
- Bioorg Med Chem Lett 15: 4872-6 (2005) 3
- Bioorg Med Chem Lett 11: 575-82 (2001) 3
- J Med Chem 48: 2121-5 (2005) 3
- Bioorg Med Chem Lett 15: 3828-33 (2005) 3
- J Med Chem 43: 4542-51 (2000) 3
- J Med Chem 46: 5471-7 (2003) 3
- Bioorg Med Chem Lett 15: 3821-7 (2005) 3
- Bioorg Med Chem Lett 14: 2351-6 (2004) 3
- Bioorg Med Chem Lett 19: 4929-32 (2009) 3
- J Med Chem 43: 4884-92 (2000) 3
- J Med Chem 46: 2197-204 (2003) 3
- J Med Chem 45: 312-20 (2002) 3
- Eur J Med Chem 62: 597-604 (2013) 3
- Bioorg Med Chem Lett 16: 2182-8 (2006) 3
- ...
Institutions 24▿
- Universit£ 77
- Istituto Di Biostrutture E Bioimmagini-Cnr 20
- Medical University Of Gdansk 18
- Kochi Medical School 10
- Universite Montpellier Ii 10
- Universita Degli Studi Di Firenze 7
- Pennsylvania State University 6
- University Of Montpellier 6
- Centre Scientifique De Monaco 5
- University Of Florida 5
- UniversitÀ Degli Studi Di Firenze 5
- Egyptian Petroleum Research Institute 4
- Slovak Academy Of Sciences 4
- Ospedale San Lazzaro 4
- University of Agricultural Sciences and Veterinary Medicine 4
- Ecole Nationale Sup£Rieure De Chimie De Montpellier 4
- University Of Tampere 4
- Bruker-Axs 3
- Università 3
- University Of Namur 3
- Balikesir University 3
- Universita Degli Studi 3
- Griffith University 3
- East China University Of Science And Technology 3
- ...
Affinity: 0.25 to 7.7E+5 nM▿
- Ki 290
- IC50 9
- EC50 2
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1