BDBM10881 CHEMBL288100::MZA3::Methazolamide::Methazolamide (MZA)::Methazolamide, MZA::N-[(2Z)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide::Sulfonamide, 2::cid_4100::sulfonamide 2

SMILES CC(=O)N=c1sc(nn1C)S(N)(=O)=O

InChI Key InChIKey=FLOSMHQXBMRNHR-UHFFFAOYSA-N

Data  290 KI  9 IC50  2 EC50

PDB links: 7 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 10881   

TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Affinity DataKi:  14nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 5A, mitochondrial(Mus musculus (mouse))
Universita Degli Studi Di Firenze

LigandPNGBDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Affinity DataKi:  63nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Bos taurus (bovine))
Universita Degli Studi Di Firenze

LigandPNGBDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Affinity DataKi:  240nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM10881(CHEMBL288100 | MZA3 | Methazolamide | Methazolamid...)
Affinity DataKi:  780nM ΔG°:  -8.33kcal/molepH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair