BDBM22199 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine::CHEMBL112280::CHEMBL286991::GBR 12935 Analogue, 36::GBR-13,069

SMILES Fc1ccc(cc1)C(OCCN1CCN(C\C=C\c2ccccc2)CC1)c1ccc(F)cc1

InChI Key InChIKey=DASHZBBQOARCMQ-QPJJXVBHSA-N

Data  16 KI  12 IC50  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 22199   

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM22199(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Affinity DataKd:  363nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM22199(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Affinity DataKd:  363nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM22199(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Affinity DataKd:  954nMAssay Description:Inhibition of [125I]RTI-55 binding to human SERT in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM22199(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Affinity DataKd:  7.76nMAssay Description:Inhibition of radioligand [125I]RTI-55 binding to human Dopamine transporter in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM22199(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Affinity DataKd:  7.80nMAssay Description:Inhibition of radioligand [125I]RTI-55 binding to human Dopamine transporter in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM22199(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Affinity DataKd:  407nMAssay Description:Inhibition of radioligand [125I]RTI-55 binding to human Dopamine transporter in clonal cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed