BDBM253921 US9464092, M::US9527857, M

SMILES C[C@H]1CN(CCN1CCC(C)(C)C)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1

InChI Key InChIKey=COALBSOMQOGPKG-NRFANRHFSA-N

Data  9 IC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 253921   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
G1 Therapeutics, Inc.

US Patent
LigandPNGBDBM253921(US9464092, M | US9527857, M)
Show SMILES C[C@H]1CN(CCN1CCC(C)(C)C)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1
Show InChI InChI=1S/C30H42N8O/c1-21-19-37(15-14-36(21)13-12-29(2,3)4)23-8-9-25(31-18-23)34-28-32-17-22-16-24-27(39)33-20-30(10-6-5-7-11-30)38(24)26(22)35-28/h8-9,16-18,21H,5-7,10-15,19-20H2,1-4H3,(H,33,39)(H,31,32,34,35)/t21-/m0/s1
Affinity DataIC50: 2.30nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
G1 Therapeutics, Inc.

US Patent
LigandPNGBDBM253921(US9464092, M | US9527857, M)
Show SMILES C[C@H]1CN(CCN1CCC(C)(C)C)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1
Show InChI InChI=1S/C30H42N8O/c1-21-19-37(15-14-36(21)13-12-29(2,3)4)23-8-9-25(31-18-23)34-28-32-17-22-16-24-27(39)33-20-30(10-6-5-7-11-30)38(24)26(22)35-28/h8-9,16-18,21H,5-7,10-15,19-20H2,1-4H3,(H,33,39)(H,31,32,34,35)/t21-/m0/s1
Affinity DataIC50: 2.28E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
G1 Therapeutics, Inc.

US Patent
LigandPNGBDBM253921(US9464092, M | US9527857, M)
Show SMILES C[C@H]1CN(CCN1CCC(C)(C)C)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1
Show InChI InChI=1S/C30H42N8O/c1-21-19-37(15-14-36(21)13-12-29(2,3)4)23-8-9-25(31-18-23)34-28-32-17-22-16-24-27(39)33-20-30(10-6-5-7-11-30)38(24)26(22)35-28/h8-9,16-18,21H,5-7,10-15,19-20H2,1-4H3,(H,33,39)(H,31,32,34,35)/t21-/m0/s1
Affinity DataIC50: 1.41E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
G1 Therapeutics, Inc.

US Patent
LigandPNGBDBM253921(US9464092, M | US9527857, M)
Show SMILES C[C@H]1CN(CCN1CCC(C)(C)C)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1
Show InChI InChI=1S/C30H42N8O/c1-21-19-37(15-14-36(21)13-12-29(2,3)4)23-8-9-25(31-18-23)34-28-32-17-22-16-24-27(39)33-20-30(10-6-5-7-11-30)38(24)26(22)35-28/h8-9,16-18,21H,5-7,10-15,19-20H2,1-4H3,(H,33,39)(H,31,32,34,35)/t21-/m0/s1
Affinity DataIC50: 2.28E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
G1 Therapeutics, Inc.

US Patent
LigandPNGBDBM253921(US9464092, M | US9527857, M)
Show SMILES C[C@H]1CN(CCN1CCC(C)(C)C)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1
Show InChI InChI=1S/C30H42N8O/c1-21-19-37(15-14-36(21)13-12-29(2,3)4)23-8-9-25(31-18-23)34-28-32-17-22-16-24-27(39)33-20-30(10-6-5-7-11-30)38(24)26(22)35-28/h8-9,16-18,21H,5-7,10-15,19-20H2,1-4H3,(H,33,39)(H,31,32,34,35)/t21-/m0/s1
Affinity DataIC50: 1.41E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
G1 Therapeutics, Inc.

US Patent
LigandPNGBDBM253921(US9464092, M | US9527857, M)
Show SMILES C[C@H]1CN(CCN1CCC(C)(C)C)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1
Show InChI InChI=1S/C30H42N8O/c1-21-19-37(15-14-36(21)13-12-29(2,3)4)23-8-9-25(31-18-23)34-28-32-17-22-16-24-27(39)33-20-30(10-6-5-7-11-30)38(24)26(22)35-28/h8-9,16-18,21H,5-7,10-15,19-20H2,1-4H3,(H,33,39)(H,31,32,34,35)/t21-/m0/s1
Affinity DataIC50: 2.30nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
G1 Therapeutics, Inc.

US Patent
LigandPNGBDBM253921(US9464092, M | US9527857, M)
Show SMILES C[C@H]1CN(CCN1CCC(C)(C)C)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1
Show InChI InChI=1S/C30H42N8O/c1-21-19-37(15-14-36(21)13-12-29(2,3)4)23-8-9-25(31-18-23)34-28-32-17-22-16-24-27(39)33-20-30(10-6-5-7-11-30)38(24)26(22)35-28/h8-9,16-18,21H,5-7,10-15,19-20H2,1-4H3,(H,33,39)(H,31,32,34,35)/t21-/m0/s1
Affinity DataIC50: 2.28E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
G1 Therapeutics, Inc.

US Patent
LigandPNGBDBM253921(US9464092, M | US9527857, M)
Show SMILES C[C@H]1CN(CCN1CCC(C)(C)C)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1
Show InChI InChI=1S/C30H42N8O/c1-21-19-37(15-14-36(21)13-12-29(2,3)4)23-8-9-25(31-18-23)34-28-32-17-22-16-24-27(39)33-20-30(10-6-5-7-11-30)38(24)26(22)35-28/h8-9,16-18,21H,5-7,10-15,19-20H2,1-4H3,(H,33,39)(H,31,32,34,35)/t21-/m0/s1
Affinity DataIC50: 2.30nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetCyclin-A1/Cyclin-dependent kinase 2(Homo sapiens (Human))
GI Therapeutics, Inc.

US Patent
LigandPNGBDBM253921(US9464092, M | US9527857, M)
Show SMILES C[C@H]1CN(CCN1CCC(C)(C)C)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1
Show InChI InChI=1S/C30H42N8O/c1-21-19-37(15-14-36(21)13-12-29(2,3)4)23-8-9-25(31-18-23)34-28-32-17-22-16-24-27(39)33-20-30(10-6-5-7-11-30)38(24)26(22)35-28/h8-9,16-18,21H,5-7,10-15,19-20H2,1-4H3,(H,33,39)(H,31,32,34,35)/t21-/m0/s1
Affinity DataIC50: 1.41E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid