BDBM31592 PF-2545920::US9138494, MP-10::substituted pyrazole, 9

SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1

InChI Key InChIKey=AZEXWHKOMMASPA-UHFFFAOYSA-N

Data  1 KI  15 IC50  3 Kd

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 31592   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL

LigandBDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)Copy SMILESCopy InChI

Affinity DataIC50:  0.370nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseDrugBankMMDBPC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedMMDB
PDB3D Structure (crystal)
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