BDBM31592 PF-2545920::US9138494, MP-10::substituted pyrazole, 9

SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1

InChI Key InChIKey=AZEXWHKOMMASPA-UHFFFAOYSA-N

Data  1 KI  15 IC50  3 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 31592   

TargetGalectin-3(Homo sapiens (Human))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Affinity DataKd:  290nMAssay Description:Binding affinity to recombinant human galectin 3 assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGalectin-3(Homo sapiens (Human))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Affinity DataKd:  150nMAssay Description:Binding affinity to recombinant human galectin 3 assessed as dissociation constant by fluorescent anisotropy assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGalectin-1(Homo sapiens (Human))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Affinity DataKd: >5.00E+5nMAssay Description:Binding affinity to recombinant human galectin 1 assessed as dissociation constant by fluorescent anisotropy assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed