BDBM409029 US10377744, Compound No. 49::US11123311, Compound 49::US11723929, Compound 49

SMILES CC[C@H](C)C(=O)N1CCC(CC(=O)Nc2ccc(OC(F)(F)F)c(F)c2)CC1

InChI Key InChIKey=GBWBRIAGOMFVIA-LBPRGKRZSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 409029   

TargetBifunctional epoxide hydrolase 2(Human)
Eicosis Human Health

Curated by ChEMBL
LigandPNGBDBM409029(US10377744, Compound No. 49 | US11123311, Compound...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to purified recombinant human sEH by FRET-displacement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Human)
Eicosis Human Health

Curated by ChEMBL
LigandPNGBDBM409029(US10377744, Compound No. 49 | US11123311, Compound...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of recombinant human sEH expressed in baculovirus expression system assessed as reduction in ACPU binding incubated for 1 hr by FRET displ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpoxide hydrolase 1(Human)
The Regents of The University of California

US Patent
LigandPNGBDBM409029(US10377744, Compound No. 49 | US11123311, Compound...)
Affinity DataKi:  3.14nMAssay Description:Scores of sEH inhibitors are known, of a variety of chemical structures. Derivatives in which the urea, carbamate or amide pharmacophore are particul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetBifunctional epoxide hydrolase 2(Human)
Eicosis Human Health

Curated by ChEMBL
LigandPNGBDBM409029(US10377744, Compound No. 49 | US11123311, Compound...)
Affinity DataKi:  3.14nMAssay Description:Any of a number of standard assays for determining epoxide hydrolase activity can be used to determine inhibition of sEH. For example, suitable assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetBifunctional epoxide hydrolase 2(Human)
Eicosis Human Health

Curated by ChEMBL
LigandPNGBDBM409029(US10377744, Compound No. 49 | US11123311, Compound...)
Affinity DataKi:  3.14nMAssay Description:FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent