BDBM50003399 4'-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-ylmethyl)-biphenyl-2-carboxylic acid::4'-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-ylmethyl)-biphenyl-2-carboxylic acid;H2O::4-Chloro-5-hydroxymethyl-3-imidazol-1-ylmethyl-biphenyl-2-carboxylic acid butyl ester::CHEMBL274447::i4'-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-ylmethyl)-biphenyl-2-carboxylic acid::{2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl}-methanol (EXP7711 (IMI))
SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
InChI Key InChIKey=UUPNFNCKGJOLQE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50003399
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
Istituto Lusofarmaco
Curated by ChEMBL
Istituto Lusofarmaco
Curated by ChEMBL
Affinity DataKi: 350nMAssay Description:Tested for the binding affinity using radioligand [125I]-Sar1 Ile8-AII in the rat adrenal capsular membranes (adrenal cortex)More data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of specific binding of [125I]-angiotensin-II to angiotensin 1 receptor in rat lung membrane preparationMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Activity against low affinity Angiotensin II receptor, type 2 was measured from the ability to inhibit [125I]-angiotensin II binding to rat uterine m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+5nMAssay Description:Activity against high affinity Angiotensin II receptor, type 1 was measured from the ability to inhibit [125I]-angiotensin II binding to rat uterine ...More data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver.More data for this Ligand-Target Pair
Affinity DataEC50: 2.70E+3nMAssay Description:Inhibition of [125I]-AII binding to angiotensin II receptor of bovine adrenal cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Inhibition of [125l]-All binding to bovine adrenal cortexMore data for this Ligand-Target Pair
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research And Development
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Antagonist activity at angiotensin 2 receptorMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
Istituto Lusofarmaco
Curated by ChEMBL
Istituto Lusofarmaco
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Ability to displace [125I]-labeled angiotensin II from its receptor of a rat uterus membraneMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
Istituto Lusofarmaco
Curated by ChEMBL
Istituto Lusofarmaco
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Ability to displace [125I]-labeled angiotensin II from its receptor of a rat uterus membraneMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
Istituto Lusofarmaco
Curated by ChEMBL
Istituto Lusofarmaco
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Ability to displace [125I]-labeled angiotensin II from its receptor of a rat uterus membraneMore data for this Ligand-Target Pair
TargetType-1/Type-2 angiotensin II receptor(Homo sapiens (Human))
Ici Pharmaceuticals Group
Curated by ChEMBL
Ici Pharmaceuticals Group
Curated by ChEMBL
Affinity DataIC50: 480nMAssay Description:Concentration required for 50% displacement of the specifically bound [3-[125I]-iodotyrosyl]-angiotensin II from angiotensin II receptor in the membr...More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor(RAT)
Istituto Lusofarmaco
Curated by ChEMBL
Istituto Lusofarmaco
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory concentration that gives 50% displacement of specific binding at labeled angiotensin II type 1 receptor in rat adrenal cortical membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory concentration that gives 50% displacement of specific binding at labeled angiotensin II type 1 receptor in rat adrenal cortical membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1More data for this Ligand-Target Pair