BDBM50030474 Avandamet::Avandaryl::Avandia::BRL-49653::CHEBI:50122::Rosiglitazone::US10744117, Compound Rosiglitazone::US9562012, rosiglitazone
SMILES CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1
InChI Key InChIKey=YASAKCUCGLMORW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 68 hits for monomerid = 50030474
Affinity DataEC50: 280nMAssay Description:Agonist activity at human PPARgamma expressed in nonhuman mammalian cells assessed as increase in receptor transcriptional activity incubated for 22 ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 18nMAssay Description:Agonist activity at GAL4-tagged human PPAR receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 260nMAssay Description:Agonist activity at N-terminal Gal4 fused human PPARgamma LBD transfected in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Transactivation of GAL4-tagged human PPARgamma LBD expressed in human HepG2 cells at 100 nM to 100 uM incubated for 20 to 22 hrs by luciferase report...More data for this Ligand-Target Pair
Affinity DataEC50: 259nMAssay Description:Transactivation of human PPARgamma transfected in U2OS cells co-tranfected with human RXR measured after 24 hrs by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 18nMAssay Description:Agonist activity at GAL4-tagged human PPAR receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 200nMAssay Description:Agonist activity at recombinant human PPARgamma LBD (205 to 505 residues) expressed in African green monkey COS-1 cells incubated for 18 hrs by lucif...More data for this Ligand-Target Pair
Affinity DataEC50: 76nMAssay Description:Agonist activity at GAL4-tagged PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as induction of receptor transactivation incubated for ...More data for this Ligand-Target Pair
Affinity DataEC50: 481nMAssay Description:Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as recruitment of TIF2 incubated for 16 hrs by luciferase reporter ...More data for this Ligand-Target Pair
Affinity DataEC50: 297nMAssay Description:Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as recruitment of MED1 incubated for 16 hrs by luciferase reporter ...More data for this Ligand-Target Pair
Affinity DataEC50: 156nMAssay Description:Agonist activity at human PPARgamma transfected in human HEK293 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
University Of Toledo College Of Pharmacy And Pharmaceutical Sciences
Curated by ChEMBL
University Of Toledo College Of Pharmacy And Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataEC50: 3.39E+3nMAssay Description:Agonist activity at human PPARalpha transfected in COS-7 cells assessed luciferase activity measured after 24 hrs by cell based luciferase transactiv...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
University Of Toledo College Of Pharmacy And Pharmaceutical Sciences
Curated by ChEMBL
University Of Toledo College Of Pharmacy And Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataEC50: 8.89E+3nMAssay Description:Agonist activity at human PPARdelta transfected in COS-7 cells assessed luciferase activity measured after 24 hrs by cell based luciferase transactiv...More data for this Ligand-Target Pair
Affinity DataEC50: 144nMAssay Description:Agonist activity at human PPARgamma transfected in COS-7 cells assessed luciferase activity measured after 24 hrs by cell based luciferase transactiv...More data for this Ligand-Target Pair
Affinity DataEC50: 1.92E+5nMAssay Description:Agonist activity at human Gal4 fused PPARgamma LBD expressed in COS-7 cells incubated for 24 hrs by firefly luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 83nMAssay Description:Agonist activity at recombinant N-terminal His6 -tagged GFP fused PPARgamma LBD (unknown origin) (203 to 477 residues) expressed in Escherichia cell ...More data for this Ligand-Target Pair
Affinity DataEC50: 169nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Partial agonist activity at sGSF-PPARgamma (unknown origin) assessed as CBP-1 recruitment by HT-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 26nMAssay Description:Partial agonist activity at PPARgamma LBD (unknown origin) assessed as increase in FITC-labeled PGC-1alpha coactivator peptide recruitment by HTRF as...More data for this Ligand-Target Pair
Affinity DataEC50: 4.40E+4nMAssay Description:Partial agonist activity at PPARgamma LBD (unknown origin) assessed as increase in FITC-labeled PGC-1alpha coactivator peptide recruitment in presenc...More data for this Ligand-Target Pair
Affinity DataEC50: 134nMAssay Description:Agonist activity at pBIND tagged human PPARgamma expressed in human HEK293 cells incubated for 18 hrs by dual luciferase reporter assay relative to c...More data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Agonist activity at yeast Gal4-fused human PPARgamma transfected in human HepG2 cells assessed as transactivation by measuring beta-galactosidase act...More data for this Ligand-Target Pair
Affinity DataEC50: 49nMAssay Description:Agonist activity at human PPARgamma expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Agonist activity at human PPARgamma measured by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Agonist activity at Gal4-fused PPARgamma (unknown origin) expressed in human U2OS cells co-transfected with pSG5 expression vector preincubated for 4...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMAssay Description:Binding affinity to PPARgamma (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 9nMAssay Description:Agonist activity at human PPARgamma transfected in HEK293 cells assessed increase in luciferase activity incubated for 24 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: 730nMAssay Description:Agonist activity at GAL4-fused human PPARgamma expressed in HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Agonist activity at PPAR-gamma in human BMMSC cells assessed as induction of adiponectin production in presence of IDX adipogenic induction medium an...More data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:After 24 h treatment with the medicament, the cells were lysed with a lysis solution (Cell Culture Lysis buffer, Promega) and centrifuged, and the su...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
University Of Toledo College Of Pharmacy And Pharmaceutical Sciences
Curated by ChEMBL
University Of Toledo College Of Pharmacy And Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataEC50: 5.25E+3nMAssay Description:After 24 h treatment with the medicament, the cells were lysed with a lysis solution (Cell Culture Lysis buffer, Promega) and centrifuged, and the su...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human PPARgamma expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.15E+4nMAssay Description:Agonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylationMore data for this Ligand-Target Pair
Affinity DataEC50: 39nMAssay Description:Agonist activity at human GAL4-PPARgamma ligand binding domain expressed in human HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Mus musculus)
Institute Of Chinese Materia Medica
Curated by ChEMBL
Institute Of Chinese Materia Medica
Curated by ChEMBL
Affinity DataEC50: 30nMAssay Description:Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Agonist activity at GAL4-DNA binding domain fused human PPARgamma ligand binding domain expressed in human HepG2 cells assessed as receptor transacti...More data for this Ligand-Target Pair
Affinity DataEC50: 87nMAssay Description:Agonist activity at human PPARgamma transfected in human MCF7 cells after 16 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
University Of Toledo College Of Pharmacy And Pharmaceutical Sciences
Curated by ChEMBL
University Of Toledo College Of Pharmacy And Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataEC50: 240nMAssay Description:Transactivation of N-terminal Gal4 DNA binding domain-linked human PPARalpha ligand binding domain after 24 hrs by luciferase reporter gene assay rel...More data for this Ligand-Target Pair
Affinity DataEC50: 89nMAssay Description:Transcriptional activation of peroxisome proliferator activated receptor gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 260nMAssay Description:Agonist activity at GAL4-tagged human PPARgamma ligand binding domain chimeric receptor expressed in HEK293 cells after 24 hrs by luciferase reporter...More data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Inhibition of FTase-catalyzed incorporation of [3H]- FPP radioligand into recombinant Ha-Ras by 50% at an enzyme concentration of 1 nM.More data for this Ligand-Target Pair
Affinity DataEC50: 95nMAssay Description:Displacement of N-terminal biotin-labeled SMRT-ID1 (2339 to 2363 residues) from recombinant GST-tagged PPARgamma (unknown origin) expressed in Escher...More data for this Ligand-Target Pair
Affinity DataEC50: 52nMAssay Description:Transactivation of recombinant GST-tagged PPARgamma (unknown origin) expressed in Escherichia coli assessed as N-terminal biotin-labeled LCOR (39 to ...More data for this Ligand-Target Pair
Affinity DataEC50: 117nMAssay Description:Transactivation of recombinant GST-tagged PPARgamma (unknown origin) expressed in Escherichia coli assessed as N-terminal biotin-labeled NCoA3 (671 t...More data for this Ligand-Target Pair
Affinity DataEC50: 316nMAssay Description:Transactivation of recombinant GST-tagged PPARgamma (unknown origin) expressed in Escherichia coli assessed as N-terminal biotin-labeled SRC1 (619 to...More data for this Ligand-Target Pair
Affinity DataEC50: 326nMAssay Description:Displacement of N-terminal biotin-labeled NCOR-ID1 (2253 to 2277 residues) from recombinant GST-tagged PPARgamma (unknown origin) expressed in Escher...More data for this Ligand-Target Pair
Affinity DataEC50: 114nMAssay Description:Transactivation of recombinant GST-tagged PPARgamma (unknown origin) expressed in Escherichia coli assessed as N-terminal biotin-labeled NCoA3 (607 t...More data for this Ligand-Target Pair
Affinity DataEC50: 332nMAssay Description:Transactivation of recombinant GST-tagged PPARgamma (unknown origin) expressed in Escherichia coli assessed as N-terminal biotin-labeled PGC1alpha (1...More data for this Ligand-Target Pair
Affinity DataEC50: 300nMAssay Description:Ability to displace [3H]quipazine binding to 5-hydroxytryptamine 3 receptor sites in NG 108-15.More data for this Ligand-Target Pair
Affinity DataEC50: 1.10E+3nMAssay Description:Transactivation activity at Gal4 fused full length human PPARgamma LBD expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair