BDBM50030474 Avandamet::Avandaryl::Avandia::BRL-49653::CHEBI:50122::Rosiglitazone::US10744117, Compound Rosiglitazone::US9562012, rosiglitazone

SMILES CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1

InChI Key InChIKey=YASAKCUCGLMORW-UHFFFAOYSA-N

Data  8 KI  34 IC50  5 Kd  68 EC50  1 Koff

PDB links: 13 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50030474   

TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Universit?? De Rennes 1

LigandPNGBDBM50030474(Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...)
Affinity DataKd:  48nMAssay Description:Binding affinity to PPARg (unknown origin) by SPR assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Universit?? De Rennes 1

LigandPNGBDBM50030474(Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...)
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to PPARgamma LBD (unknown origin) assessed as dissociation constant followed by heating for 3 mins by Bradford assayMore data for this Ligand-Target Pair
LigandPNGBDBM50030474(Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...)
Affinity DataKd:  650nMAssay Description:Binding affinity to human PPARgamma-LBD (206 to 477 residues)/human RXRalpha-LBD (224 to 462 residues) heterodimer assessed as dissociation constant ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50030474(Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...)
Affinity DataKd:  1.50E+4nMAssay Description:Binding affinity to RXRalpha-LBD (unknown origin) measured up to 120 sec by surface plasma resonance methodMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Universit?? De Rennes 1

LigandPNGBDBM50030474(Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...)
Affinity DataKd:  1.20nMAssay Description:Inhibition of FTase-catalyzed incorporation of [3H]- FPP radioligand into recombinant Ha-Ras by 50% at an enzyme concentration of 1 nM.More data for this Ligand-Target Pair