BDBM50030474 Avandamet::Avandaryl::Avandia::BRL-49653::CHEBI:50122::Rosiglitazone::US10744117, Compound Rosiglitazone::US9562012, rosiglitazone
SMILES CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1
InChI Key InChIKey=YASAKCUCGLMORW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 50030474
TargetPeroxisome proliferator-activated receptor alpha(Mus musculus)
Terns Pharmaceuticals
Curated by ChEMBL
Terns Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Activation of mouse liver PPARalphaMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.95E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 76nMAssay Description:Displacement of fluormone PPAR green tracer ligand from recombinant GST-tagged PPARgamma ligand binding domain (unknown origin) incubated for 4 hrs b...More data for this Ligand-Target Pair
TargetSodium/bile acid cotransporter(Homo sapiens (Human))
Southwest Jiaotong University
Curated by ChEMBL
Southwest Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of HA-tagged human NTCP expressed in human U2OS cells assessed as reduction in [14C]taurocholate uptake preincubated for 10 mins followed ...More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Norman Drug Discovery Training And Consulting
Curated by ChEMBL
Norman Drug Discovery Training And Consulting
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human BSEP expressed in HEK293 cell membrane vesicles assessed as reduction in 3H-TCA uptake incubated for 5 mins by radiodetection met...More data for this Ligand-Target Pair
Affinity DataIC50: 88nMAssay Description:Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of NCoR incubated for 16 hrs by luciferase reporter...More data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of SMRT incubated for 16 hrs by luciferase reporter...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Comsats University Islamabad
Curated by ChEMBL
Comsats University Islamabad
Curated by ChEMBL
Affinity DataIC50: 832nMAssay Description:Inhibition of recombinant human MAO-BMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Binding affinity to PPARgamma (unknown origin) by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of PPARgamma (unknown origin) phosphorylation at pS273 residueMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 76nMAssay Description:Agonist activity at PPARgamma ligand binding domain (unknown origin) using fluormone Pan-PPAR green tracer by TR-FRET assay based competitive ligand ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Norman Drug Discovery Training And Consulting
Curated by ChEMBL
Norman Drug Discovery Training And Consulting
Curated by ChEMBL
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Binding affinity to GST-tagged human PPAR-gamma receptor by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]rosiglitazone from human recombinant PPARgamma receptor expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 125nMAssay Description:PPARγ binding is measured by a TR-FRET competitive binding assay using Invitrogen LanthaScreen TR-FRET PPARγ Competitive Binding Assay (I...More data for this Ligand-Target Pair
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))
West Virginia University
Curated by ChEMBL
West Virginia University
Curated by ChEMBL
Affinity DataIC50: 731nMAssay Description:Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...More data for this Ligand-Target Pair
Affinity DataIC50: 292nMAssay Description:Displacement of fluormone-PPARgamma Green from recombinant human N-terminal GST-tagged PPARgamma-LBD by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]rosiglitazone from human recombinant PPAR-gamma receptor expressed in Escherichia coli measured after 120 mins by scintillation c...More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Norman Drug Discovery Training And Consulting
Curated by ChEMBL
Norman Drug Discovery Training And Consulting
Curated by ChEMBL
Affinity DataIC50: 3.75E+3nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell plasma membrane vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Norman Drug Discovery Training And Consulting
Curated by ChEMBL
Norman Drug Discovery Training And Consulting
Curated by ChEMBL
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Norman Drug Discovery Training And Consulting
Curated by ChEMBL
Norman Drug Discovery Training And Consulting
Curated by ChEMBL
Affinity DataIC50: 6.36E+3nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 103nMAssay Description:Inhibition of fluormone PPARgamma Green binding to recombinant N-terminal GST-tagged human PPARgamma LBD by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
Norman Drug Discovery Training And Consulting
Curated by ChEMBL
Norman Drug Discovery Training And Consulting
Curated by ChEMBL
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Transrepression activity at human PPARgamma expressed in HEK293 cells assessed as inhibition of TNFalpha induced NF-kappaB promoter activity pretreat...More data for this Ligand-Target Pair
Affinity DataIC50: 298nMAssay Description:Displacement of fluormone-PPARgamma green from GST-tagged PPARgamma-LBD (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair
Affinity DataIC50: 159nMAssay Description:Displacement of fluormone from human PPARgamma LBD expressed in Escherichia coli BL21 DE3 by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetCDGSH iron-sulfur domain-containing protein 1(Rattus norvegicus)
Northeastern Ohio Universities
Curated by ChEMBL
Northeastern Ohio Universities
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [3H]rosiglitazone from rat liver mitochondrial mitoNEET by scintillation countingMore data for this Ligand-Target Pair
TargetCDGSH iron-sulfur domain-containing protein 2(Homo sapiens)
West Virginia University
Curated by ChEMBL
West Virginia University
Curated by ChEMBL
Affinity DataIC50: 2.29E+3nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged NAF1 expressed in Escherichia coli by scintillation proximity assayMore data for this Ligand-Target Pair