BDBM50073587 CHEMBL3408947::US10358436, Example A185::US20230365537, Example CFI-400495::US9907800, Example A185

SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1

InChI Key

Data  2 KI  27 IC50  13 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50073587   

TargetSerine/threonine-protein kinase PLK4 [1-391](Homo sapiens (Human))
University Health Network

US Patent
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataIC50: <100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
University Health Network

US Patent
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataIC50: <500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
University Health Network

US Patent
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataIC50: <100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4 [1-391](Homo sapiens (Human))
University Health Network

US Patent
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataIC50: <100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
University Health Network

US Patent
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataIC50: <500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
University Health Network

US Patent
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataIC50: <100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Health Network

US Patent
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataIC50:  550nMAssay Description:PLK3 inhibition was determined using the Z-Lyte assay kit from Invitrogen (cat #PV3802). The assay was performed using the recommended manufacturer&#...More data for this Ligand-Target Pair
In DepthDetails US Patent