BDBM50100615 E-7050::E7050::Golvatinib

SMILES CN1CCN(CC1)C1CCN(CC1)C(=O)Nc1cc(Oc2ccc(NC(=O)C3(CC3)C(=O)Nc3ccc(F)cc3)c(F)c2)ccn1

InChI Key InChIKey=UQRCJCNVNUFYDX-UHFFFAOYSA-N

Data  7 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50100615   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50100615(E-7050 | E7050 | Golvatinib)
Affinity DataIC50:  14nMAssay Description:Inhibition of c-Met autophosphorylation in human MKN45 cells after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50100615(E-7050 | E7050 | Golvatinib)
Affinity DataIC50:  16nMAssay Description:Inhibition of VEGFR-2 autophosphorylation in HUVEC after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed