BDBM50265951 CHEMBL1657::TAZAROTENE::US9963439, Tazarotene::ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl]nicotinate

SMILES CCOC(=O)c1ccc(nc1)C#Cc1ccc2SCCC(C)(C)c2c1

InChI Key InChIKey=OGQICQVSFDPSEI-UHFFFAOYSA-N

Data  5 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50265951   

TargetRetinoic acid receptor beta(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50265951(ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-...)
Affinity DataEC50:  0.800nMAssay Description:Activity at human RARbeta ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRetinoic acid receptor gamma(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50265951(ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-...)
Affinity DataEC50:  40nMAssay Description:Activity at human RARgamma ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRetinoic acid receptor alpha(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50265951(ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-...)
Affinity DataEC50:  63nMAssay Description:Activity at human RARalpha ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50265951(ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-...)
Affinity DataIC50: 3.15E+3nMAssay Description:Compounds were assessed for inhibition (IC50, n=2) of CYP2C8, CYP2C9 and CYP3A4 in pooled human liver microsomes using selective probe substrates at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
Go to US Patent

LigandPNGBDBM50265951(ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50265951(ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50265951(ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50265951(ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed