BDBM50370595 OXYCODONE::Oxycontin::US1184575, oxycodone::US9233167, Oxycodone
SMILES COc1ccc2C[C@H]3N(C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
InChI Key InChIKey=BRUQQQPBMZOVGD-XFKAJCMBSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 32 hits for monomerid = 50370595
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 8.90nMAssay Description:Displacement of [3H]DAMGO from MOR in Wistar rat brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 60 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHOK1 cell membranes incubated for 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHOK1 cell membranes incubated for 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Radioligand dose-displacement binding assays for μ-opioid receptors can use 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, CT), with 5 mg mem...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 43.6nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor of rat brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 133nM ΔG°: -9.37kcal/moleT: 2°CAssay Description:Briefly, serial dilutions of the test compounds were placed in a 96-well plate to which were added SPA beads, membrane and radioligand. The assay con...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 325nMAssay Description:Displacement of [3H]HS-665 from KOR in guinea pig brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 487nMAssay Description:Displacement of [3H]Ile5,6-deltorphin-2 from DOR in Wistar rat brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: 1.09E+3nMAssay Description:Displacement of [3H[Ile5,6]-deltorphin II from delta opioid receptor of rat brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 2.66E+3nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor of rat brain membranesMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H][Ile5,6]deltorphin2 from delta opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma-1 receptor expressed in HEK293 membranes incubated for 120 mins by liquid scintillation countin...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]JWH-018 from CB1R/CB2R in Wistar rat brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of 3H](+)-pentazocine from human sigma1 receptor expressed in HEK293 cell membranes incubated for 120 mins by liquid scintillation count...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma-1 receptor transfected in HEK293 membranes incubated for 120 mins measured by microBeta scintil...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]WIN-55,212-2 from CB1R/CB2R in Wistar rat brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Agonist activity at human MOR expressed in CHO-K1 cells assessed as reduction in forskolin-induced cAMP production incubated for 45 mins by by HTRF a...More data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Agonist activity at human MOR expressed in CHOK1 cells assessed as stimulation of cAMP accumulation incubated for 45 mins by HTRF assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Esteve Pharmaceuticals
Curated by ChEMBL
Esteve Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Biological Research Centre Of The Hungarian Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 25nMAssay Description:Agonist activity at MOR in Wistar rat brain membranes after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
University Medicine Greifswald
Curated by ChEMBL
University Medicine Greifswald
Curated by ChEMBL
Affinity DataIC50: 2.00E+6nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 17nMAssay Description:Agonist activity at human MOR expressed in CHOK1 cells assessed as stimulation of cAMP accumulation incubated for 45 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 500nMAssay Description:Agonist activity at human MOR assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by cell based TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 160nMAssay Description:Agonist activity at mouse MOR assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by cell based TR-FRET assayMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Mus musculus (Mouse))
University Of Texas At Austin
Curated by ChEMBL
University Of Texas At Austin
Curated by ChEMBL
Affinity DataEC50: 1.60E+4nMAssay Description:Agonist activity at mouse KOR assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by cell based TR-FRET assayMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Texas At Austin
Curated by ChEMBL
University Of Texas At Austin
Curated by ChEMBL
Affinity DataEC50: 4.00E+3nMAssay Description:Agonist activity at human DOR assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by cell based TR-FRET assayMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Texas At Austin
Curated by ChEMBL
University Of Texas At Austin
Curated by ChEMBL
Affinity DataEC50: 1.60E+4nMAssay Description:Agonist activity at human KOR assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by cell based TR-FRET assayMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
University Of Innsbruck And Center For Molecular Biosciences Innsbruck-Cmbi
Curated by ChEMBL
University Of Innsbruck And Center For Molecular Biosciences Innsbruck-Cmbi
Curated by ChEMBL
Affinity DataIC50: 7.62E+4nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataEC50: 478nMT: 2°CAssay Description:Briefly, suspensions of cells expressing either the mu, kappa or delta opioid receptors were prepared in buffer containing 0.5 mM isobutyl-methyl xan...More data for this Ligand-Target Pair