BDBM50462621 CHEMBL1813256::MLN-9708::US11542283, Compound MLN-9708
SMILES CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B1OC(=O)CC(CC(O)=O)(O1)C(O)=O
InChI Key InChIKey=YTXSYWAKVMZICI-PVCZSOGJSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50462621
TargetProteasome subunit beta type-2(Homo sapiens (Human))
Nanjing Forestry University
Curated by ChEMBL
Nanjing Forestry University
Curated by ChEMBL
Affinity DataIC50: 7.95E+3nMAssay Description:Inhibition of trypsin-like activity of human 20S proteasomeMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University
Curated by ChEMBL
Nanjing Forestry University
Curated by ChEMBL
Affinity DataIC50: 8.40nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 7.47nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
TargetATP-dependent Clp protease proteolytic subunit(Staphylococcus aureus (strain NCTC 8325))
Sichuan University
Curated by ChEMBL
Sichuan University
Curated by ChEMBL
Affinity DataKd: 7.30E+3nMAssay Description:Binding affinity to N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) by ITC analysisMore data for this Ligand-Target Pair
TargetATP-dependent Clp protease proteolytic subunit(Staphylococcus aureus (strain NCTC 8325))
Sichuan University
Curated by ChEMBL
Sichuan University
Curated by ChEMBL
Affinity DataEC50: 1.99E+4nMAssay Description:Binding affinity to N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) assessed as shifting o...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Nanjing Forestry University
Curated by ChEMBL
Nanjing Forestry University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of caspase-like activity of human 20S proteasomeMore data for this Ligand-Target Pair