BDBM50554790 CHEMBL4781849

SMILES CC[C@@H](c1nc2cccc(F)c2c(=O)n1C1CC1)n1nc(-c2ccc(OC)c(F)c2)c2c(N)ncnc12

InChI Key InChIKey=HTUBTEAYSCSTIY-SFHVURJKSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50554790   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Hefei Institutes Of Physical Science

Curated by ChEMBL
LigandPNGBDBM50554790(CHEMBL4781849)
Affinity DataEC50:  67nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in anti-IgM stimulated AKT T308 phosphorylation incubated for 1 hr by Western blot ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Hefei Institutes Of Physical Science

Curated by ChEMBL
LigandPNGBDBM50554790(CHEMBL4781849)
Affinity DataIC50:  14nMAssay Description:Inhibition of human PI3Kdelta using substrate PIP2:PS and ATP incubated for 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Hefei Institutes Of Physical Science

Curated by ChEMBL
LigandPNGBDBM50554790(CHEMBL4781849)
Affinity DataIC50:  1.38E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hefei Institutes Of Physical Science

Curated by ChEMBL
LigandPNGBDBM50554790(CHEMBL4781849)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) incubated for 20 to 30 mins by P450-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Hefei Institutes Of Physical Science

Curated by ChEMBL
LigandPNGBDBM50554790(CHEMBL4781849)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin) incubated for 20 to 30 mins by P450-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Hefei Institutes Of Physical Science

Curated by ChEMBL
LigandPNGBDBM50554790(CHEMBL4781849)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin) incubated for 20 to 30 mins by P450-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Hefei Institutes Of Physical Science

Curated by ChEMBL
LigandPNGBDBM50554790(CHEMBL4781849)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin) incubated for 20 to 30 mins by P450-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Hefei Institutes Of Physical Science

Curated by ChEMBL
LigandPNGBDBM50554790(CHEMBL4781849)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin) incubated for 20 to 30 mins by P450-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed