BDBM50560888 CHEMBL4749646

SMILES CC(C)c1ccn2ncnc(N[C@H]3CC[C@H](CC3)N3CCN(CC3)C(=O)CCC(=O)N3CCC(CCN4CCN(CC4)c4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)c12

InChI Key InChIKey=ZUODKONSNNHSAJ-AMLBMYBGSA-N

Data  8 IC50  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50560888   

TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged IRAK1 (194 to 712 residues) expressed in baculovirus expression system using 5-FAM-KKKVSRSGLYRS...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Affinity DataIC50:  5nMAssay Description:Inhibition of kinase tracer 236 binding to recombinant human full-length GST-tagged IRAK3 expressed in insect cells by Lanthascreen Eu kinase binding...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of recombinant human full-length His-tagged IRAK4 expressed in baculovirus expression system using 5-FAM-IPTSPITTTYFFFKKK-COOH as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Affinity DataIC50:  110nMAssay Description:Inhibition of GSG2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Affinity DataIC50:  16nMAssay Description:Inhibition of CDK11/cyclin C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Affinity DataIC50:  460nMAssay Description:Inhibition of CRBN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Affinity DataKd:  780nMAssay Description:Displacement of polymer supported probe 25 binding to GSG2 in human THP-1 cell lysates preincubated for 45 mins under shaking condition followed by p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Affinity DataIC50:  100nMAssay Description:Inhibition of NTRK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Affinity DataKd:  2.80E+3nMAssay Description:Displacement of polymer supported probe 25 binding to IRAK1 in human THP-1 cell lysates preincubated for 45 mins under shaking condition followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Affinity DataKd:  34nMAssay Description:Displacement of polymer supported probe 25 binding to IRAK3 in human THP-1 cell lysates preincubated for 45 mins under shaking condition followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Affinity DataKd:  3.60E+3nMAssay Description:Displacement of polymer supported probe 25 binding to IRAK4 in human THP-1 cell lysates preincubated for 45 mins under shaking condition followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Affinity DataKd:  1.40E+3nMAssay Description:Displacement of polymer supported probe 25 binding to CDK8 in human THP-1 cell lysates preincubated for 45 mins under shaking condition followed by p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 19(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Affinity DataKd: >3.00E+4nMAssay Description:Displacement of polymer supported probe 25 binding to CDK11 in human THP-1 cell lysates preincubated for 45 mins under shaking condition followed by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560888(CHEMBL4749646)
Affinity DataIC50:  36nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed