Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with Target = 'Beta-secretase 1 [1-454]'
TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 210888BDBM210888(US9290477, 6)
Affinity DataIC50: 1.5nMpH: 4.4Assay Description:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) containing th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 210887BDBM210887(US9290477, 5)
Affinity DataIC50: 1.5nMpH: 4.4Assay Description:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) containing th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150700BDBM150700(US8981112, 7 | US9526727, 7 | US9949975, Example 7)
Affinity DataIC50: 2nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150705BDBM150705(US8981112, 12 | US9526727, 12 | US9949975, Example...)
Affinity DataIC50: 3nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 210884BDBM210884(US9290477, 2)
Affinity DataIC50: 3.5nMpH: 4.4Assay Description:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) containing th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150704BDBM150704(US8981112, 11 | US9526727, 11 | US9949975, Example...)
Affinity DataIC50: 4nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 210883BDBM210883(US9290477, 1)
Affinity DataIC50: 4nMpH: 4.4Assay Description:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) containing th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150701BDBM150701(US8981112, 8 | US9526727, 8 | US9949975, Example 8)
Affinity DataIC50: 5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150717BDBM150717(US8981112, 24 | US9526727, 24 | US9949975, Example...)
Affinity DataIC50: 5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150697BDBM150697(US8981112, 4 | US9526727, 4)
Affinity DataIC50: 5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150714BDBM150714(US8981112, 21 | US9526727, 21 | US9949975, Example...)
Affinity DataIC50: 5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150707BDBM150707(US8981112, 14 | US9526727, 14 | US9949975, Example...)
Affinity DataIC50: 5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150720BDBM150720(US8981112, 27 | US9526727, 27 | US9949975, Example...)
Affinity DataIC50: 6nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150712BDBM150712(US8981112, 19 | US9526727, 19 | US9949975, Example...)
Affinity DataIC50: 6nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 259489BDBM259489(US9526727, 5)
Affinity DataIC50: 8nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150715BDBM150715(US8981112, 22 | US9526727, 22 | US9949975, Example...)
Affinity DataIC50: 8nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150695BDBM150695(US8981112, 2 | US9526727, 2 | US9949975, Example 2)
Affinity DataIC50: 8nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 210889BDBM210889(US9290477, 7)
Affinity DataIC50: 8.20nMpH: 4.4Assay Description:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) containing th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150706BDBM150706(US8981112, 13 | US9526727, 13 | US9949975, Example...)
Affinity DataIC50: 9nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150703BDBM150703(US8981112, 10 | US9526727, 10 | US9949975, Example...)
Affinity DataIC50: 9nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150719BDBM150719(US8981112, 26 | US9526727, 26 | US9949975, Example...)
Affinity DataIC50: 9nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150702BDBM150702(US8981112, 9 | US9526727, 9 | US9949975, Example 9)
Affinity DataIC50: 9nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150711BDBM150711(US8981112, 18 | US9526727, 18 | US9949975, Example...)
Affinity DataIC50: 9nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150696BDBM150696(US8981112, 3 | US9526727, 3 | US9949975, Example 3)
Affinity DataIC50: 10nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150699BDBM150699(US8981112, 6 | US9526727, 6 | US9949975, Example 6)
Affinity DataIC50: 11nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150709BDBM150709(US8981112, 16 | US9526727, 16 | US9949975, Example...)
Affinity DataIC50: 11nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 259488BDBM259488(US9526727, 1 | US9949975, Example 1)
Affinity DataIC50: 11nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150708BDBM150708(US8981112, 15 | US9526727, 15 | US9949975, Example...)
Affinity DataIC50: 11nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150716BDBM150716(US8981112, 23 | US9526727, 23 | US9949975, Example...)
Affinity DataIC50: 12nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 150710BDBM150710(US8981112, 17 | US9526727, 17 | US9949975, Example...)
Affinity DataIC50: 14nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 210886BDBM210886(US9290477, 4)
Affinity DataIC50: 16.3nMpH: 4.4Assay Description:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) containing th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 259485BDBM259485(US9526727, Comparison Example Table 2, 2''-amino-4...)
Affinity DataIC50: 35nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 210885BDBM210885(US9290477, 3)
Affinity DataIC50: 37nMpH: 4.4Assay Description:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) containing th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 259486BDBM259486(US9526727, Comparison Example Table 2, (1r,4r)-2''...)
Affinity DataIC50: 49nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 195494BDBM195494(US9212153, 158,Ex. 121 | US9526727, Comparison Exa...)
Affinity DataIC50: 107nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

TargetBeta-secretase 1 [1-454](Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 259487BDBM259487(US9526727, Comparison Example Table 2, (1r,1'R,4R)...)
Affinity DataIC50: 415nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent