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Report error Found 891 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 9'
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM19410(benzamide-type inhibitor, 3 | CHEMBL27759 | pyridi...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant human HDAC9 using pan-HDAC substrate incubated for 3 hrs by fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant human HDAC9 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataKi:  1.20nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50268097(6-{[2-(9H-Fluoren-9-yliden)acetyl]amino}-N-hydroxy...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant HDAC9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50563276(CHEMBL4751615)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of recombinant human HDAC9 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50268063((E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-(7-quinoliny...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human recombinant HDAC9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataKi:  3.80nMAssay Description:Inhibition of human HDAC9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50268121((E)-3-(4-Chloro-2-fluorophenyl)-N-[6-(hydroxyamino...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human recombinant HDAC9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50268042((2E,4E)-N-[6-(Hydroxyamino)-6-oxohexyl]-3-methyl-5...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human recombinant HDAC9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50353234(CHEMBL1830537)
Affinity DataKi:  4.40nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50044636(CHEMBL3309297)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human HDAC9 pre-incubated for 30 mins before substrate addition and measured after 30 mins by HDAC-Glo I/II assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataKi:  5.30nMAssay Description:Inhibition of human recombinant HDAC9 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50353233(CHEMBL1830536)
Affinity DataKi:  5.70nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human recombinant HDAC9 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of recombinant HDAC9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50319209(6-[3-(4-Bromo-benzoyl)-ureido]-hexanoic acid hydro...)
Affinity DataKi:  6nMAssay Description:Inhibition of HDAC9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 6nMAssay Description:Inhibition of HDAC9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of recombinant full length human HDAC9 expressed in SF9 baculovirus using FAM- labelled acetylated peptide as substrate measured by Electr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of recombinant human HDAC9 (604-1066 residues) expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50517218(CHEMBL4525406)
Affinity DataKi:  8nMAssay Description:Inhibition of HDAC9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM19428(NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human HDAC9 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant HDAC9 using Boc-Lys(tri-fluoroacetyl)-AMC as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50581678(CHEMBL5072502)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant HDAC9 (unknown origin) using Boc-Lys(trifluoroacetyl)-AMC as substrate pre-incubated for 1 hr followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM162846(US9056843, 137)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC9 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50353229(CHEMBL1830397)
Affinity DataKi:  11nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50353232(CHEMBL1830424)
Affinity DataKi:  11nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM272075((S)-1-(2,6-Difluorophenyl)-5-(3-fluoro-2- methylph...)
Affinity DataIC50: 12nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM272075((S)-1-(2,6-Difluorophenyl)-5-(3-fluoro-2- methylph...)
Affinity DataIC50: 12nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetHistone deacetylase 9 [604-1066](Human)
Reaction Biology

US Patent
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 12.9nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM162846(US9056843, 137)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant HDAC9 (unknown origin) using Boc-Lys(TFA)-AMC as substrate by fluorescence based plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50353230(CHEMBL1830420)
Affinity DataKi:  14nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM272071((S)-1-(2-Chlorophenyl)-5-(3-fluoro-2-methylphenyl)...)
Affinity DataIC50: 15nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM272078((S)-1-(2-Chloro-6-fluorophenyl)-5-(3-fluoro-2- met...)
Affinity DataIC50: 15nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM272071((S)-1-(2-Chlorophenyl)-5-(3-fluoro-2-methylphenyl)...)
Affinity DataIC50: 15nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM272078((S)-1-(2-Chloro-6-fluorophenyl)-5-(3-fluoro-2- met...)
Affinity DataIC50: 15nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50563276(CHEMBL4751615)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human HDAC9 using Ac-LGK(TFA)-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50353231(CHEMBL1830422)
Affinity DataKi:  16nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM272074((S)-1-(3-Chloro-2-fluorophenyl)-5-(3-fluoro-2- met...)
Affinity DataIC50: 17nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM272067((S)-5-(3-Fluoro-2-methylphenyl)-l-(2-fluorophenyl)...)
Affinity DataIC50: 17nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM272074((S)-1-(3-Chloro-2-fluorophenyl)-5-(3-fluoro-2- met...)
Affinity DataIC50: 17nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM272067((S)-5-(3-Fluoro-2-methylphenyl)-l-(2-fluorophenyl)...)
Affinity DataIC50: 17nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant HDAC9 (unknown origin) using trifluoroacetyl lysine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM272079((S)-5-(3-Fluoro-2-methylphenyl)-1-(2-fluoro-6- met...)
Affinity DataIC50: 19nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Affinity DataKi:  19nMAssay Description:Inhibition of human HDAC9 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50248476(US8551988, 72 | CHEMBL491316 | SB-639 | N-hydroxy-...)
Affinity DataKi:  19nMAssay Description:Inhibition of recombinant HDAC9 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM272079((S)-5-(3-Fluoro-2-methylphenyl)-1-(2-fluoro-6- met...)
Affinity DataIC50: 19nMAssay Description:The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50353227(CHEMBL3215861)
Affinity DataKi:  19nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50248476(US8551988, 72 | CHEMBL491316 | SB-639 | N-hydroxy-...)
Affinity DataKi:  19nMAssay Description:Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
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