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Report error Found 260 Enz. Inhib. hit(s) with Target = 'NUAK family SNF1-like kinase 1'
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human ARK5 using KKKVSRSGLYRSPSMPENLNRPR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human ARK5 using KKKVSRSGLYRSPSMPENLNRPR as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human ARK5 using KKKVSRSGLYRSPSMPENLNRPR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human ARK5 using KKKVSRSGLYRSPSMPENLNRPR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human ARK5 using KKKVSRSGLYRSPSMPENLNRPR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50587681(CHEMBL5176650)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50653007(CHEMBL5303523)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of GST-tagged NUAK1 (unknown origin) expressed in HEK293 cells using ALNRTSSDSALHRRR as substrate incubated for 30 mins in presence of [ga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50248946(CHEMBL1908392 | US10981896, Compound 16)
Affinity DataKi:  1.70nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50248946(CHEMBL1908392 | US10981896, Compound 16)
Affinity DataKi:  1.70nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged NUAK1 expressed in baculovirus infected Sf9 insect cells using CHK peptide as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2019
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of NUAK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50152595(CHEMBL3780091)
Affinity DataIC50: 2nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50622916(CHEMBL5305160)
Affinity DataIC50: 3nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50587679(CHEMBL5199998)
Affinity DataIC50: 3nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50587677(CHEMBL5173501)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  3.70nMAssay Description:Binding affinity to ARK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  3.70nMAssay Description:Binding constant for ARK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50: 4nMAssay Description:Inhibition of ARK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50: 4nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50536679(CHEMBL4568087)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of full-length recombinant human His-tagged NUAK1 expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  4.40nMAssay Description:Binding constant for ARK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  4.40nMAssay Description:Binding constant for ARK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  4.40nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50587683(CHEMBL5196626)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 5nMAssay Description:Inhibition of ARK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681 | US20250129067, Compound ON123300)
Affinity DataIC50: 5nMAssay Description:Inhibition of human NUAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM17051(N-{3-[(5-iodo-4-{[3-(thiophen-2-ylformamido)propyl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50208911(CHEMBL3884319)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant full length His-tagged NUAK1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM86615(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 2...)
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50587672(CHEMBL5192992)
Affinity DataIC50: 7nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50055496(CHEMBL3326006)
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal GST-tagged full length human NuaK1 (1 to 661 end residues) expressed in baculovirus expression system using fluorecence-labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50055496(CHEMBL3326006)
Affinity DataIC50: 8nMAssay Description:Inhibition of Nuak1 (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2016
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 8nMAssay Description:Inhibition of ARK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50248938(CHEMBL4089284 | US10981896, Compound 21)
Affinity DataKi:  8.60nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50248938(CHEMBL4089284 | US10981896, Compound 21)
Affinity DataKi:  8.60nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged NUAK1 expressed in baculovirus infected Sf9 insect cells using CHK peptide as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2019
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50587682(CHEMBL5204647)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50: 10nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50248937(CHEMBL4062168 | US10981896, Compound 15)
Affinity DataKi:  11nMAssay Description:Candidates for inhibitor selectivity characterization were chosen based on an initial single-timepoint commercial kinome profiling screen performed w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50248937(CHEMBL4062168 | US10981896, Compound 15)
Affinity DataKi:  11nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged NUAK1 expressed in baculovirus infected Sf9 insect cells using CHK peptide as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2019
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  13nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged NUAK1 (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  13nMAssay Description:Binding constant for ARK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  13nMAssay Description:Binding affinity to NUAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  15nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged NUAK1 (unknown origin) expressed in baculovirus infected Sf9 insect cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50587673(CHEMBL5175737)
Affinity DataIC50: 15nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50: 15nMAssay Description:Inhibition of full-length recombinant human His-tagged NUAK1 expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50587670(CHEMBL5202161)
Affinity DataIC50: 17nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50536678(CHEMBL4550702)
Affinity DataIC50: 19nMAssay Description:Inhibition of full-length recombinant human His-tagged NUAK1 expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataIC50: 20nMAssay Description:Inhibition of GST-tagged NUAK1 (unknown origin) expressed in HEK293 cells using ALNRTSSDSALHRRR as substrate incubated for 30 mins in presence of [ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
Gachon University

Curated by ChEMBL
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50: 25nMAssay Description:Inhibition of human ARK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
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