Report error Found 1120 Enz. Inhib. hit(s) with Target = 'Plasmepsin I'
Affinity DataKi: 0.100nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
Affinity DataIC50: 0.130nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2 by FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibitory concentration against the plasmepsin-1 of Plasmodium falciparumMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibitory concentration against the plasmepsin-1 of Plasmodium falciparumMore data for this Ligand-Target Pair
TargetPlasmepsin IV [1-448](malaria parasite P. falciparum)
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 4 using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate preincubated for 30 mins followed by...More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibitory concentration against the plasmepsin-1 of Plasmodium falciparumMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibitory concentration against the plasmepsin-1 of Plasmodium falciparumMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibition of Plasmodium falciparum PLM2 using Lys-Glu-Phe-Val-Phe-NPhe-Ala-Leu-Lys as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 0.420nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2 using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate preincubated for 30 mins followed by...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2 expressed in Escherichia coli BL21 (DE3) by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibitory concentration against the plasmepsin-1 of Plasmodium falciparumMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
Affinity DataKi: 0.560nMAssay Description:Inhibition of Plasmodium falciparum recombinant plasmepsin-2 expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
Affinity DataKi: 0.560nMAssay Description:Inhibitory concentration against the plasmepsin-2 of Plasmodium falciparumMore data for this Ligand-Target Pair
Affinity DataKi: 0.560nM ΔG°: -52.3kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
Affinity DataIC50: 0.590nMAssay Description:In vitro concentration required for inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
Affinity DataIC50: 0.590nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
Affinity DataKi: 0.680nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
Affinity DataIC50: 0.680nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2 by FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Inhibitory concentration against the plasmepsin-1 of Plasmodium falciparumMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Inhibition of recombinant Plasmodium falciparum Plasmepsin 1More data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-1 using DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS as substrate preincubated for 30 mins followed by...More data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Inhibitory concentration against the plasmepsin-2 of Plasmodium falciparumMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibitory concentration against the plasmepsin-1 of Plasmodium falciparumMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of Plasmodium falciparum recombinant PLM1More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibitory concentration against the plasmepsin-1 of Plasmodium falciparumMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibitory concentration against the plasmepsin-2 of Plasmodium falciparumMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibitory concentration against the plasmepsin-2 of Plasmodium falciparumMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibition of Plasmodium falciparum PLM2 using Lys-Glu-Phe-Val-Phe-NPhe-Ala-Leu-Lys as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Plasmodium falciparum 3D7 HA-glms-tagged PMIX using DABCYL-HSFIQEGKEE-EDANS as substrate measured after 2 hrs by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:In vitro concentration required for inhibition of Plasmodium falciparum plasmepsin-2More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Inhibition of Plasmodium falciparum plasmepsin 2More data for this Ligand-Target Pair
Affinity DataIC50: 1.88nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Inhibitory concentration against the plasmepsin-2 of Plasmodium falciparumMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Inhibitory concentration against the plasmepsin-1 of Plasmodium falciparumMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Inhibition of Plasmodium falciparum PLM2 using Lys-Glu-Phe-Val-Phe-NPhe-Ala-Leu-Lys as substrate by spectrophotometryMore data for this Ligand-Target Pair

3D Structure (crystal)































