Compile Data Set for Download or QSAR
Report error Found 820 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase receptor R3'
TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160301(US9040691, 29)
Affinity DataIC50: 1nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160276(US9040691, 4)
Affinity DataIC50: 1nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160312(US9040691, 42 | US9040691, 41 | US9040691, 40)
Affinity DataIC50: 1.20nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160277(US9040691, 5)
Affinity DataIC50: 1.30nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.36nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM50262079(LDN-193189 | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo...)
Affinity DataIC50: 1.48nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM102619(K02288a | US10688093, Compound 382_0087_0284 | US1...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of GST-tagged human recombinant ALK1 expressed in baculovirus expression system using casein as substrate in presence of [gamma-32P]ATP in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160283(US9040691, 11)
Affinity DataIC50: 1.90nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160315(US9040691, 43)
Affinity DataIC50: 1.90nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160302(US9040691, 30)
Affinity DataIC50: 2nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160279(US9040691, 7)
Affinity DataIC50: 2nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160273(US9040691, 1)
Affinity DataIC50: 2nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160289(US9040691, 17)
Affinity DataIC50: 2nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM102618(LDN-212854)
Affinity DataIC50: 2.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160288(US9040691, 16)
Affinity DataIC50: 2.60nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160274(US9040691, 2)
Affinity DataIC50: 2.80nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataKd:  2.90nMAssay Description:Binding constant for ACVRL1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160309(US9040691, 37)
Affinity DataIC50: 3nMAssay Description:ALKl (Invitrogen, Carlsbad, CA, USA) kinase activity was measured at ProQinase GmbH ( Freiburg. Germany) in a radiometric assay using gamma-33P-ATP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160283(US9040691, 11)
Affinity DataIC50: 3nMAssay Description:ALKl (Invitrogen, Carlsbad, CA, USA) kinase activity was measured at ProQinase GmbH ( Freiburg. Germany) in a radiometric assay using gamma-33P-ATP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160312(US9040691, 42 | US9040691, 41 | US9040691, 40)
Affinity DataIC50: 3.20nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160312(US9040691, 42 | US9040691, 41 | US9040691, 40)
Affinity DataIC50: 3.5nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Mouse)
Massachusetts Institute of Technology

LigandPNGBDBM102619(K02288a | US10688093, Compound 382_0087_0284 | US1...)
Affinity DataIC50: 3.65nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160316(US9040691, 44)
Affinity DataIC50: 3.80nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM143311(US9682983, 11 | US10017516, Compound 11)
Affinity DataIC50: 4nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM111123(US9682983, 2 | US10017516, Compound 2)
Affinity DataIC50: 4nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160285(US9040691, 13)
Affinity DataIC50: 4nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160310(US9040691, 38)
Affinity DataIC50: 4nMAssay Description:ALKl (Invitrogen, Carlsbad, CA, USA) kinase activity was measured at ProQinase GmbH ( Freiburg. Germany) in a radiometric assay using gamma-33P-ATP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160303(US9040691, 31)
Affinity DataIC50: 4nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160304(US9040691, 32)
Affinity DataIC50: 4nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM143311(US9682983, 11 | US10017516, Compound 11)
Affinity DataIC50: 4nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM161920(US9682983, 52 | US9682983, 53 | US10017516, Compou...)
Affinity DataIC50: 4nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160275(US9040691, 3)
Affinity DataIC50: 4nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160306(US9040691, 34)
Affinity DataIC50: 4.10nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160280(US9040691, 36 | US9040691, 35 | US9040691, 8)
Affinity DataIC50: 4.40nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM130912(US8822500, [1])
Affinity DataIC50: 4.70nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM50560477(CHEMBL4742906)
Affinity DataIC50: 5nMAssay Description:Inhibition of human ALK1 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160286(US9040691, 14)
Affinity DataIC50: 5.30nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160311(US9040691, 39)
Affinity DataIC50: 5.70nMAssay Description:ALKl (Invitrogen, Carlsbad, CA, USA) kinase activity was measured at ProQinase GmbH ( Freiburg. Germany) in a radiometric assay using gamma-33P-ATP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160281(US9040691, 9)
Affinity DataIC50: 5.70nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM111123(US9682983, 2 | US10017516, Compound 2)
Affinity DataIC50: 5.80nMAssay Description:Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM111123(US9682983, 2 | US10017516, Compound 2)
Affinity DataIC50: 5.80nMpH: 7.5Assay Description:Specifically, compounds were assayed using LANCE Ultra ULight technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2-6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160284(US9040691, 12)
Affinity DataIC50: 5.90nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM518186(US11111247, Example 17)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of recombinant human C-terminal GST tagged ALK1 (144 to end residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160279(US9040691, 7)
Affinity DataIC50: 6.70nMAssay Description:ALKl (Invitrogen, Carlsbad, CA, USA) kinase activity was measured at ProQinase GmbH ( Freiburg. Germany) in a radiometric assay using gamma-33P-ATP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160280(US9040691, 36 | US9040691, 35 | US9040691, 8)
Affinity DataIC50: 6.90nMAssay Description:ALKl (Invitrogen, Carlsbad, CA, USA) kinase activity was measured at ProQinase GmbH ( Freiburg. Germany) in a radiometric assay using gamma-33P-ATP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM50528190(CHEMBL4548795)
Affinity DataIC50: 7nMAssay Description:Inhibition of human ALK1 using casein as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM160282(US9040691, 10)
Affinity DataIC50: 8nMAssay Description:In vitro enzyme inhibition using scintillation of incorporated radio label (flashplate assay). Test compounds diluted in DMSO are mixed with a suitab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM130919(US8822500, [18])
Affinity DataIC50: 9.16nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM130910(US8822500, [4])
Affinity DataIC50: 9.81nMpH: 7.5Assay Description:Compounds to be tested were dissolved in 100% DMSO in a range of concentrations from 10-8 to 10-3 M including negative control (DMSO), then diluted w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2015
Entry Details
US Patent

TargetSerine/threonine-protein kinase receptor R3(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human C-terminal GST tagged ALK1 (144 to end residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
Displayed 1 to 50 (of 820 total ) | Next | Last >>
Jump to: